JPS55102600A - Guanosine derivative, and antileukemic agent containing the same - Google Patents
Guanosine derivative, and antileukemic agent containing the sameInfo
- Publication number
- JPS55102600A JPS55102600A JP13470878A JP13470878A JPS55102600A JP S55102600 A JPS55102600 A JP S55102600A JP 13470878 A JP13470878 A JP 13470878A JP 13470878 A JP13470878 A JP 13470878A JP S55102600 A JPS55102600 A JP S55102600A
- Authority
- JP
- Japan
- Prior art keywords
- guanosine
- monophosphate
- salt
- same
- agent containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:Guanosine-3'-diphosphate, and its salt.
USE: An effective component of an antileukemic agent having high effectivity and safety.
PROCESS: Guanosine-3'-diphosphate is prepared by phosphatizing quanosine-3'-monophosphate. The phosphatization is carried out at follows; (1) guanosine-3'-monophosphate is dissolved in ammonia water containing formamide, (2) adding a DCC- containing tert-butanol to the solution, (3) converting the monophosphate to guanosine-3'-monophosphoroamidate by heating the mixture while preventing the evaporation of the solvent, (4) dissolving the amidate together with phosphoric anhydride in pyridine to phosphatize the amidate, (5) precipitating the product as lithium salt of guanosine-3'-disphosphate, (6) removing the salt, (7) concentrating in vacuo, and (8) freeze-drying the product.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13470878A JPS55102600A (en) | 1978-10-31 | 1978-10-31 | Guanosine derivative, and antileukemic agent containing the same |
GB7937442A GB2037289B (en) | 1978-10-31 | 1979-10-29 | Nucleoside derivatives and an antileukemial agent containing the same as an active ingredient |
FR7927023A FR2440375A1 (en) | 1978-10-31 | 1979-10-31 | NUCLEOSIDE DERIVATIVES AND THEIR THERAPEUTIC APPLICATION |
DE19792944084 DE2944084A1 (en) | 1978-10-31 | 1979-10-31 | 3'-POLYPHOSPHATES OF PYRIMIDINE NUCLEOSIDES OR OF GUANOSINE AND THEIR SALTS AND THE USE OF THESE COMPOUNDS FOR THE TREATMENT OF LEUKAEMIA |
US06/089,887 US4297347A (en) | 1978-10-31 | 1979-10-31 | Nucleoside derivatives and an antileukemial agent containing the same as an active ingredient |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13470878A JPS55102600A (en) | 1978-10-31 | 1978-10-31 | Guanosine derivative, and antileukemic agent containing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55102600A true JPS55102600A (en) | 1980-08-05 |
JPS6140209B2 JPS6140209B2 (en) | 1986-09-08 |
Family
ID=15134733
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13470878A Granted JPS55102600A (en) | 1978-10-31 | 1978-10-31 | Guanosine derivative, and antileukemic agent containing the same |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55102600A (en) |
-
1978
- 1978-10-31 JP JP13470878A patent/JPS55102600A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6140209B2 (en) | 1986-09-08 |
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