JPS55102600A - Guanosine derivative, and antileukemic agent containing the same - Google Patents

Guanosine derivative, and antileukemic agent containing the same

Info

Publication number
JPS55102600A
JPS55102600A JP13470878A JP13470878A JPS55102600A JP S55102600 A JPS55102600 A JP S55102600A JP 13470878 A JP13470878 A JP 13470878A JP 13470878 A JP13470878 A JP 13470878A JP S55102600 A JPS55102600 A JP S55102600A
Authority
JP
Japan
Prior art keywords
guanosine
monophosphate
salt
same
agent containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13470878A
Other languages
Japanese (ja)
Other versions
JPS6140209B2 (en
Inventor
Nobuhiko Katsunuma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to JP13470878A priority Critical patent/JPS55102600A/en
Priority to GB7937442A priority patent/GB2037289B/en
Priority to FR7927023A priority patent/FR2440375A1/en
Priority to DE19792944084 priority patent/DE2944084A1/en
Priority to US06/089,887 priority patent/US4297347A/en
Publication of JPS55102600A publication Critical patent/JPS55102600A/en
Publication of JPS6140209B2 publication Critical patent/JPS6140209B2/ja
Granted legal-status Critical Current

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  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:Guanosine-3'-diphosphate, and its salt.
USE: An effective component of an antileukemic agent having high effectivity and safety.
PROCESS: Guanosine-3'-diphosphate is prepared by phosphatizing quanosine-3'-monophosphate. The phosphatization is carried out at follows; (1) guanosine-3'-monophosphate is dissolved in ammonia water containing formamide, (2) adding a DCC- containing tert-butanol to the solution, (3) converting the monophosphate to guanosine-3'-monophosphoroamidate by heating the mixture while preventing the evaporation of the solvent, (4) dissolving the amidate together with phosphoric anhydride in pyridine to phosphatize the amidate, (5) precipitating the product as lithium salt of guanosine-3'-disphosphate, (6) removing the salt, (7) concentrating in vacuo, and (8) freeze-drying the product.
COPYRIGHT: (C)1980,JPO&Japio
JP13470878A 1978-10-31 1978-10-31 Guanosine derivative, and antileukemic agent containing the same Granted JPS55102600A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP13470878A JPS55102600A (en) 1978-10-31 1978-10-31 Guanosine derivative, and antileukemic agent containing the same
GB7937442A GB2037289B (en) 1978-10-31 1979-10-29 Nucleoside derivatives and an antileukemial agent containing the same as an active ingredient
FR7927023A FR2440375A1 (en) 1978-10-31 1979-10-31 NUCLEOSIDE DERIVATIVES AND THEIR THERAPEUTIC APPLICATION
DE19792944084 DE2944084A1 (en) 1978-10-31 1979-10-31 3'-POLYPHOSPHATES OF PYRIMIDINE NUCLEOSIDES OR OF GUANOSINE AND THEIR SALTS AND THE USE OF THESE COMPOUNDS FOR THE TREATMENT OF LEUKAEMIA
US06/089,887 US4297347A (en) 1978-10-31 1979-10-31 Nucleoside derivatives and an antileukemial agent containing the same as an active ingredient

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13470878A JPS55102600A (en) 1978-10-31 1978-10-31 Guanosine derivative, and antileukemic agent containing the same

Publications (2)

Publication Number Publication Date
JPS55102600A true JPS55102600A (en) 1980-08-05
JPS6140209B2 JPS6140209B2 (en) 1986-09-08

Family

ID=15134733

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13470878A Granted JPS55102600A (en) 1978-10-31 1978-10-31 Guanosine derivative, and antileukemic agent containing the same

Country Status (1)

Country Link
JP (1) JPS55102600A (en)

Also Published As

Publication number Publication date
JPS6140209B2 (en) 1986-09-08

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