FR2437411A1 - PROCESS FOR BROMINATING ALKALOIDS IN RYE ERGOT AND COMPOUNDS OBTAINED - Google Patents
PROCESS FOR BROMINATING ALKALOIDS IN RYE ERGOT AND COMPOUNDS OBTAINEDInfo
- Publication number
- FR2437411A1 FR2437411A1 FR7923816A FR7923816A FR2437411A1 FR 2437411 A1 FR2437411 A1 FR 2437411A1 FR 7923816 A FR7923816 A FR 7923816A FR 7923816 A FR7923816 A FR 7923816A FR 2437411 A1 FR2437411 A1 FR 2437411A1
- Authority
- FR
- France
- Prior art keywords
- alkaloids
- ergot
- rye
- brominating
- compounds obtained
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Abstract
L'INVENTION CONCERNE UN PROCEDE DE PREPARATION DES ALCALOIDES DE L'ERGOT DE SEIGLE DE FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE R REPRESENTE UN GROUPE CARBOXY, ALCOXY-CARBONYLE, CARBAMOYLE EVENTUELLEMENT SUBSTITUE, OU UN GROUPE CARBAMOYLE SUBSTITUE PAR UN RESTE PEPTIDIQUE APPARTENANT AUX ALCALOIDES DE L'ERGOT DE SEIGLE. SELON LE PROCEDE DE L'INVENTION, ON BROME UN COMPOSE CORRESPONDANT DE FORMULE: (CF DESSIN DANS BOPI) PAR REACTION AVEC UN COMPLEXE DE BROME DE LA 3-BROMO-6-CHLORO-2-METHYL-IMIDAZO1,2-BPYRIDAZINE. CE PROCEDE PERMET DE BROMER SELECTIVEMENT LES ALCALOIDES DE L'ERGOT DE SEIGLE.THE INVENTION CONCERNS A PROCESS FOR THE PREPARATION OF ALKALOIDS FROM RYE ERGOT OF FORMULA: (CF DRAWING IN BOPI) IN WHICH R REPRESENTS A CARBOXY, ALCOXY-CARBONYL, CARBAMOYL, POSSIBLY SUBSTITUTED, OR A SMALL CARBAMOYL GROUP. BELONGING TO THE ALKALOIDS OF ERGOT OF RYE. ACCORDING TO THE PROCESS OF THE INVENTION, A CORRESPONDING COMPOUND OF FORMULA: (CF DRAWING IN BOPI) IS BROMINATED BY REACTION WITH A 3-BROMO-6-CHLORO-2-METHYL-IMIDAZO1,2-BPYRIDAZINE BROMINE COMPLEX. THIS PROCESS ALLOWS SELECTIVELY BROMING THE ALKALOIDS OF RYE ERGOT.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| YU2268/78A YU39849B (en) | 1978-09-26 | 1978-09-26 | Process for preparing 2-bromo-ergolene and 2-bromo-ergoline compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2437411A1 true FR2437411A1 (en) | 1980-04-25 |
| FR2437411B1 FR2437411B1 (en) | 1983-03-18 |
Family
ID=25557457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7923816A Granted FR2437411A1 (en) | 1978-09-26 | 1979-09-25 | PROCESS FOR BROMINATING ALKALOIDS IN RYE ERGOT AND COMPOUNDS OBTAINED |
Country Status (45)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU196394B (en) * | 1986-06-27 | 1988-11-28 | Richter Gedeon Vegyeszet | Process for preparing 2-halogenated ergoline derivatives |
| CN104016982A (en) * | 2014-06-26 | 2014-09-03 | 华东理工大学 | Method for preparing fumigaclavine C by using macroporous resin |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2009737A1 (en) * | 1968-05-31 | 1970-02-06 | Sandoz Sa | |
| DE2752532A1 (en) * | 1976-12-23 | 1978-06-29 | Lek Tovarna Farmacevtskih | PROCESS FOR THE PREPARATION OF 2-BROMOMALPHA-ERGOCRYPTINE |
| EP0001115A2 (en) * | 1977-09-09 | 1979-03-21 | LEK, tovarna farmacevtskih in kemicnih izdelkov, n.sol.o. | 2-Bromo-ergosine and its acid addition salts, method for its preparation and its application as a medicine |
-
1978
- 1978-09-26 YU YU2268/78A patent/YU39849B/en unknown
-
1979
- 1979-09-19 IT IT7950300A patent/IT1206988B/en active
- 1979-09-20 CH CH8492/79A patent/CH649769A5/en not_active IP Right Cessation
- 1979-09-21 DE DE19792938313 patent/DE2938313A1/en active Granted
- 1979-09-24 PT PT70216A patent/PT70216A/en unknown
- 1979-09-24 BE BE1/9540A patent/BE878953A/en not_active IP Right Cessation
- 1979-09-24 CY CY1240A patent/CY1240A/en unknown
- 1979-09-24 FI FI792957A patent/FI66185C/en not_active IP Right Cessation
- 1979-09-24 GB GB7932989A patent/GB2031890B/en not_active Expired
- 1979-09-24 LU LU81714A patent/LU81714A1/en unknown
- 1979-09-24 GR GR60103A patent/GR73015B/el unknown
- 1979-09-24 AT AT0624379A patent/AT376439B/en not_active IP Right Cessation
- 1979-09-24 MX MX798393U patent/MX5864E/en unknown
- 1979-09-24 DD DD79215747A patent/DD146048A5/en not_active IP Right Cessation
- 1979-09-24 IS IS2512A patent/IS2512A7/en unknown
- 1979-09-24 NZ NZ191643A patent/NZ191643A/en unknown
- 1979-09-24 AR AR278180A patent/AR223496A1/en active
- 1979-09-24 NO NO793058A patent/NO153852C/en unknown
- 1979-09-24 HU HU79SA3200A patent/HU182576B/en unknown
- 1979-09-25 MA MA18795A patent/MA18595A1/en unknown
- 1979-09-25 BG BG044956A patent/BG32716A3/en unknown
- 1979-09-25 PL PL1979218497A patent/PL120388B1/en unknown
- 1979-09-25 DK DK401979A patent/DK149956C/en not_active IP Right Cessation
- 1979-09-25 SU SU792818045A patent/SU1178324A3/en active
- 1979-09-25 IL IL58318A patent/IL58318A/en unknown
- 1979-09-25 SE SE7907942A patent/SE433497B/en not_active IP Right Cessation
- 1979-09-25 AU AU51172/79A patent/AU529462B2/en not_active Ceased
- 1979-09-25 ES ES484445A patent/ES484445A1/en not_active Expired
- 1979-09-25 FR FR7923816A patent/FR2437411A1/en active Granted
- 1979-09-25 UA UA2818045A patent/UA7078A1/en unknown
- 1979-09-25 NL NL7907122A patent/NL7907122A/en not_active Application Discontinuation
- 1979-09-25 CS CS796471A patent/CS215027B2/en unknown
- 1979-09-25 JP JP12373279A patent/JPS5545699A/en active Granted
- 1979-09-25 PH PH23062A patent/PH14986A/en unknown
- 1979-09-25 RO RO7998760A patent/RO78936A/en unknown
- 1979-09-25 EG EG566/79A patent/EG14277A/en active
- 1979-09-26 BR BR7906175A patent/BR7906175A/en unknown
- 1979-09-26 IE IE1832/79A patent/IE49076B1/en not_active IP Right Cessation
- 1979-09-26 ZA ZA00795110A patent/ZA795110B/en unknown
- 1979-09-26 CA CA336,448A patent/CA1128038A/en not_active Expired
-
1980
- 1980-09-23 IN IN1077/CAL/80A patent/IN154914B/en unknown
-
1984
- 1984-03-05 SG SG204/84A patent/SG20484G/en unknown
- 1984-04-12 KE KE3392A patent/KE3392A/en unknown
- 1984-06-14 HK HK491/84A patent/HK49184A/en not_active IP Right Cessation
-
1985
- 1985-12-30 MY MY131/85A patent/MY8500131A/en unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2009737A1 (en) * | 1968-05-31 | 1970-02-06 | Sandoz Sa | |
| CH507249A (en) * | 1968-05-31 | 1971-05-15 | Sandoz Ag | Process for the preparation of 2-bromo-a-ergocryptine |
| DE2752532A1 (en) * | 1976-12-23 | 1978-06-29 | Lek Tovarna Farmacevtskih | PROCESS FOR THE PREPARATION OF 2-BROMOMALPHA-ERGOCRYPTINE |
| FR2375242A1 (en) * | 1976-12-23 | 1978-07-21 | Lek Tovarna Farmacevtskih | PROCESS FOR PREPARING 2-BROMO-A-ERGOCRYPTINE |
| EP0001115A2 (en) * | 1977-09-09 | 1979-03-21 | LEK, tovarna farmacevtskih in kemicnih izdelkov, n.sol.o. | 2-Bromo-ergosine and its acid addition salts, method for its preparation and its application as a medicine |
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TP | Transmission of property | ||
| ST | Notification of lapse |