FR2375242A1 - PROCESS FOR PREPARING 2-BROMO-A-ERGOCRYPTINE - Google Patents

PROCESS FOR PREPARING 2-BROMO-A-ERGOCRYPTINE

Info

Publication number
FR2375242A1
FR2375242A1 FR7738976A FR7738976A FR2375242A1 FR 2375242 A1 FR2375242 A1 FR 2375242A1 FR 7738976 A FR7738976 A FR 7738976A FR 7738976 A FR7738976 A FR 7738976A FR 2375242 A1 FR2375242 A1 FR 2375242A1
Authority
FR
France
Prior art keywords
ergocryptine
bromo
alpha
preparation
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7738976A
Other languages
French (fr)
Other versions
FR2375242B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lek Pharmaceuticals dd
Original Assignee
Lek Pharmaceuticals and Chemical Co dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek Pharmaceuticals and Chemical Co dd filed Critical Lek Pharmaceuticals and Chemical Co dd
Publication of FR2375242A1 publication Critical patent/FR2375242A1/en
Application granted granted Critical
Publication of FR2375242B1 publication Critical patent/FR2375242B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/02—Ergot alkaloids of the cyclic peptide type

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Procédé de préparation de 2-bromo- alpha -ergocryptine. Il est caractérisé par le fait qu'en atomophère inerte, on brome l' alpha -ergocryptine au moyen d'hydrotribromure de pyrrolidone ou de N-bromosaccharine en solution dans un éther cyclique en présence d'un amorceur à radicaux, à la température ambiante ou à température légèrement élevée. Applicable notamment à la preparation de produits utilisables dans le traitement du cancer du sein, et pour l'inhibition de la sécrétion de l'hormone prolactine et de l'hormone de croissance.Process for the preparation of 2-bromo-alpha -ergocryptine. It is characterized by the fact that in an inert atomophère, the alpha -ergocryptine is brominated by means of pyrrolidone or N-bromosaccharine hydrotribromide in solution in a cyclic ether in the presence of a radical initiator, at room temperature. or at slightly elevated temperature. Applicable in particular to the preparation of products which can be used in the treatment of breast cancer, and for the inhibition of the secretion of the hormone prolactin and of the growth hormone.

FR7738976A 1976-12-23 1977-12-23 PROCESS FOR PREPARING 2-BROMO-A-ERGOCRYPTINE Granted FR2375242A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU3134/76A YU39786B (en) 1976-12-23 1976-12-23 Process for preparing 2-bromo-alfa-ergocriptine

Publications (2)

Publication Number Publication Date
FR2375242A1 true FR2375242A1 (en) 1978-07-21
FR2375242B1 FR2375242B1 (en) 1983-01-14

Family

ID=25559398

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7738976A Granted FR2375242A1 (en) 1976-12-23 1977-12-23 PROCESS FOR PREPARING 2-BROMO-A-ERGOCRYPTINE

Country Status (18)

Country Link
JP (1) JPS5384997A (en)
BE (1) BE903269Q (en)
CS (1) CS215105B2 (en)
DD (1) DD134101A1 (en)
DE (1) DE2752532C3 (en)
ES (1) ES465096A1 (en)
FR (1) FR2375242A1 (en)
GB (1) GB1574479A (en)
HK (1) HK4786A (en)
HU (1) HU176817B (en)
KE (1) KE3572A (en)
PL (1) PL106363B1 (en)
PT (1) PT67340A (en)
RO (1) RO71277A (en)
SG (1) SG71885G (en)
SU (1) SU795477A3 (en)
UA (1) UA8031A1 (en)
YU (1) YU39786B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2437411A1 (en) * 1978-09-26 1980-04-25 Sandoz Sa PROCESS FOR BROMINATING ALKALOIDS IN RYE ERGOT AND COMPOUNDS OBTAINED

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU216177A (en) 1977-09-09 1984-02-29 Rudolf Rucman Process for preparing 2-bromo ergosine

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2009737A1 (en) * 1968-05-31 1970-02-06 Sandoz Sa
EP0001115A2 (en) * 1977-09-09 1979-03-21 LEK, tovarna farmacevtskih in kemicnih izdelkov, n.sol.o. 2-Bromo-ergosine and its acid addition salts, method for its preparation and its application as a medicine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2009737A1 (en) * 1968-05-31 1970-02-06 Sandoz Sa
CH507249A (en) * 1968-05-31 1971-05-15 Sandoz Ag Process for the preparation of 2-bromo-a-ergocryptine
EP0001115A2 (en) * 1977-09-09 1979-03-21 LEK, tovarna farmacevtskih in kemicnih izdelkov, n.sol.o. 2-Bromo-ergosine and its acid addition salts, method for its preparation and its application as a medicine

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EXBK/63 *
EXBK/65 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2437411A1 (en) * 1978-09-26 1980-04-25 Sandoz Sa PROCESS FOR BROMINATING ALKALOIDS IN RYE ERGOT AND COMPOUNDS OBTAINED

Also Published As

Publication number Publication date
ES465096A1 (en) 1978-09-01
PL202697A1 (en) 1978-07-31
FR2375242B1 (en) 1983-01-14
DD134101A1 (en) 1979-02-07
JPS5384997A (en) 1978-07-26
RO71277A (en) 1982-02-01
KE3572A (en) 1985-11-08
UA8031A1 (en) 1995-12-26
YU39786B (en) 1985-04-30
SG71885G (en) 1988-09-30
YU313476A (en) 1982-05-31
HK4786A (en) 1986-01-31
HU176817B (en) 1981-05-28
CS215105B2 (en) 1982-07-30
GB1574479A (en) 1980-09-10
BE903269Q (en) 1986-01-16
DE2752532A1 (en) 1978-06-29
SU795477A3 (en) 1981-01-07
DE2752532C3 (en) 1980-09-18
PT67340A (en) 1977-12-01
DE2752532B2 (en) 1979-12-06
JPS5550038B2 (en) 1980-12-16
PL106363B1 (en) 1979-12-31

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