FR2432525A1 - Nouveaux derives de la doxorubicine, leur preparation et les compositions qui les contiennent - Google Patents
Nouveaux derives de la doxorubicine, leur preparation et les compositions qui les contiennentInfo
- Publication number
- FR2432525A1 FR2432525A1 FR7919890A FR7919890A FR2432525A1 FR 2432525 A1 FR2432525 A1 FR 2432525A1 FR 7919890 A FR7919890 A FR 7919890A FR 7919890 A FR7919890 A FR 7919890A FR 2432525 A1 FR2432525 A1 FR 2432525A1
- Authority
- FR
- France
- Prior art keywords
- preparation
- compositions containing
- doxorubicin derivatives
- derivatives
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical class O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- -1 hydroxy, mercapto, methylthio Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BE869485 | 1978-08-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2432525A1 true FR2432525A1 (fr) | 1980-02-29 |
FR2432525B1 FR2432525B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1983-12-02 |
Family
ID=3861689
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7919890A Granted FR2432525A1 (fr) | 1978-08-03 | 1979-08-02 | Nouveaux derives de la doxorubicine, leur preparation et les compositions qui les contiennent |
Country Status (6)
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6107285A (en) * | 1985-08-02 | 2000-08-22 | Pharmacia & Upjohn Company | Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5124318A (en) * | 1985-08-02 | 1992-06-23 | Farmitalia Carlo Erba S.R.L. | Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
US5977082A (en) | 1985-08-02 | 1999-11-02 | Pharmacia & Upjohn Company | Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
US5599686A (en) * | 1994-06-28 | 1997-02-04 | Merck & Co., Inc. | Peptides |
US5866679A (en) * | 1994-06-28 | 1999-02-02 | Merck & Co., Inc. | Peptides |
US6143864A (en) * | 1994-06-28 | 2000-11-07 | Merck & Co., Inc. | Peptides |
BE1008581A3 (fr) * | 1994-08-19 | 1996-06-04 | Wallone Region | Prodrogues, composition pharmaceutique les comprenant et leur utilisation. |
DE69535665T2 (de) * | 1994-08-19 | 2009-04-02 | La Region Wallonne | Konjugate enthaltend ein antitumorales mittel und deren verwendung |
JP2543434Y2 (ja) * | 1996-04-15 | 1997-08-06 | マツダ株式会社 | エンジンの排気管構造 |
US5998362A (en) * | 1996-09-12 | 1999-12-07 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
US5948750A (en) * | 1996-10-30 | 1999-09-07 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
US6391305B1 (en) | 1997-09-10 | 2002-05-21 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
TR200002260T2 (tr) * | 1997-12-02 | 2000-12-21 | Merck & Co., Inc. | Prostat kanserinin tedavisinde yararlı konjugatlar |
ZA9810974B (en) * | 1997-12-02 | 1999-06-03 | Merck & Co Inc | Conjugates useful in the treatment of prostate cancer |
US20040081659A1 (en) * | 1997-12-02 | 2004-04-29 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
US6174858B1 (en) | 1998-11-17 | 2001-01-16 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
US7425541B2 (en) * | 1998-12-11 | 2008-09-16 | Medarex, Inc. | Enzyme-cleavable prodrug compounds |
WO2001028593A2 (en) | 1999-10-19 | 2001-04-26 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
EP1228089A2 (en) | 1999-10-27 | 2002-08-07 | Merck & Co., Inc. | Salt form of a conjugate useful in the treatment of prostate cancer |
AU1374601A (en) * | 1999-11-12 | 2001-05-30 | Angiotech International Ag | Compositions and methods for treating disease utilizing a combination of radioactive therapy and cell-cycle inhibitors |
JP2004510702A (ja) | 2000-06-14 | 2004-04-08 | メダレックス,インコーポレイティド | イソロイシンを有するプロドラッグ化合物 |
WO2002015700A1 (en) * | 2000-08-24 | 2002-02-28 | Coulter Pharmaceutical, Inc. | Prodrugs activated by plasmin and their use in cancer chemotherapy |
US20030232760A1 (en) * | 2001-09-21 | 2003-12-18 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
US20030216758A1 (en) * | 2001-12-28 | 2003-11-20 | Angiotech Pharmaceuticals, Inc. | Coated surgical patches |
US8313760B2 (en) | 2002-05-24 | 2012-11-20 | Angiotech International Ag | Compositions and methods for coating medical implants |
WO2003099346A2 (en) | 2002-05-24 | 2003-12-04 | Angiotech International Ag | Compositions and methods for coating medical implants |
CA2633589A1 (en) | 2002-09-26 | 2004-04-08 | Angiotech International Ag | Perivascular wraps |
DE60331367D1 (de) | 2002-12-30 | 2010-04-01 | Angiotech Int Ag | Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung |
CA2536242A1 (en) * | 2003-11-20 | 2005-06-09 | Angiotech International Ag | Implantable sensors and implantable pumps and anti-scarring agents |
EP1718145A4 (en) | 2004-02-02 | 2012-03-07 | Biosight Ltd | CONJUGATES FOR CANCER THERAPY AND DIAGNOSIS |
AU2005100176A4 (en) * | 2005-03-01 | 2005-04-07 | Gym Tv Pty Ltd | Garbage bin clip |
US9789209B2 (en) | 2013-03-14 | 2017-10-17 | The Regents Of The University Of California, Berke | Activatable membrane-interacting peptides and methods of use |
CA3007065C (en) | 2015-12-03 | 2023-02-14 | Biosight Ltd. | Salts of conjugates for cancer therapy |
US12064445B2 (en) | 2015-12-03 | 2024-08-20 | Biosight Ltd. | Cytarabine conjugates for cancer therapy |
US12071450B2 (en) | 2015-12-03 | 2024-08-27 | Biosight Ltd. | Salts of conjugates for cancer therapy |
JP7149183B2 (ja) | 2015-12-03 | 2022-10-06 | バイオサイト リミテッド | 癌治療のためのシタラビンコンジュゲート |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR7164M (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1968-02-22 | 1969-08-04 | ||
FR2430425A1 (fr) * | 1978-07-07 | 1980-02-01 | Rhone Poulenc Ind | Nouveaux derives de la daunorubicine, leur preparation et les compositions pharmaceutiques qui les contiennent |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1578734A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1967-11-28 | 1969-08-22 | ||
FI51808C (fi) * | 1968-07-15 | 1977-04-12 | Rhone Poulenc Sa | Menetelmä uusien kasvainten naftaseenijohdannaisten valmistamiseksi. |
GB1500421A (en) * | 1975-01-22 | 1978-02-08 | Farmaceutici Italia | Optically active anthracyclinones |
US4012448A (en) * | 1976-01-15 | 1977-03-15 | Stanford Research Institute | Synthesis of adriamycin and 7,9-epiadriamycin |
-
1979
- 1979-07-05 US US06/055,291 patent/US4296105A/en not_active Expired - Lifetime
- 1979-07-26 CA CA332,572A patent/CA1115694A/en not_active Expired
- 1979-07-31 GB GB7926641A patent/GB2027024B/en not_active Expired
- 1979-08-02 NL NL7905953A patent/NL191150C/xx not_active IP Right Cessation
- 1979-08-02 FR FR7919890A patent/FR2432525A1/fr active Granted
- 1979-08-02 JP JP9910779A patent/JPS5522697A/ja active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR7164M (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1968-02-22 | 1969-08-04 | ||
FR2430425A1 (fr) * | 1978-07-07 | 1980-02-01 | Rhone Poulenc Ind | Nouveaux derives de la daunorubicine, leur preparation et les compositions pharmaceutiques qui les contiennent |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6107285A (en) * | 1985-08-02 | 2000-08-22 | Pharmacia & Upjohn Company | Injectable ready-to-use solutions containing an antitumor anthracycline glycoside |
Also Published As
Publication number | Publication date |
---|---|
US4296105A (en) | 1981-10-20 |
FR2432525B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1983-12-02 |
GB2027024B (en) | 1983-04-27 |
GB2027024A (en) | 1980-02-13 |
NL191150B (nl) | 1994-09-16 |
JPS6259715B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1987-12-12 |
NL7905953A (nl) | 1980-02-05 |
JPS5522697A (en) | 1980-02-18 |
NL191150C (nl) | 1995-02-16 |
CA1115694A (en) | 1982-01-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |