FR2432525A1 - Nouveaux derives de la doxorubicine, leur preparation et les compositions qui les contiennent - Google Patents

Nouveaux derives de la doxorubicine, leur preparation et les compositions qui les contiennent

Info

Publication number
FR2432525A1
FR2432525A1 FR7919890A FR7919890A FR2432525A1 FR 2432525 A1 FR2432525 A1 FR 2432525A1 FR 7919890 A FR7919890 A FR 7919890A FR 7919890 A FR7919890 A FR 7919890A FR 2432525 A1 FR2432525 A1 FR 2432525A1
Authority
FR
France
Prior art keywords
preparation
compositions containing
doxorubicin derivatives
derivatives
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7919890A
Other languages
English (en)
Other versions
FR2432525B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INST INT PATHOLOGIE CELLULAIRE
Original Assignee
INST INT PATHOLOGIE CELLULAIRE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by INST INT PATHOLOGIE CELLULAIRE filed Critical INST INT PATHOLOGIE CELLULAIRE
Publication of FR2432525A1 publication Critical patent/FR2432525A1/fr
Application granted granted Critical
Publication of FR2432525B1 publication Critical patent/FR2432525B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Nouveaux dérivés de la doxorubicine de formule générale I dans laquelle R est un radical de formule II dans laquelle R1 est hydrogène, alcoyle (éventuellement substitué par amino, alcoylamino, dialcoylamino, hydroxy, mercapto, méthylthio), phényle, benzyle (éventuellement substitué par un ou deux hydroxy), R2 est hydrogène ou forme avec R1 un radical alcoylène, leur préparation, leurs sels et les compositions qui les contiennent. Ces nouveaux dérivés sont utilisables pour le traitement des tumeurs :
FR7919890A 1978-08-03 1979-08-02 Nouveaux derives de la doxorubicine, leur preparation et les compositions qui les contiennent Granted FR2432525A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BE869485 1978-08-03

Publications (2)

Publication Number Publication Date
FR2432525A1 true FR2432525A1 (fr) 1980-02-29
FR2432525B1 FR2432525B1 (fr) 1983-12-02

Family

ID=3861689

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7919890A Granted FR2432525A1 (fr) 1978-08-03 1979-08-02 Nouveaux derives de la doxorubicine, leur preparation et les compositions qui les contiennent

Country Status (6)

Country Link
US (1) US4296105A (fr)
JP (1) JPS5522697A (fr)
CA (1) CA1115694A (fr)
FR (1) FR2432525A1 (fr)
GB (1) GB2027024B (fr)
NL (1) NL191150C (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6107285A (en) * 1985-08-02 2000-08-22 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5977082A (en) * 1985-08-02 1999-11-02 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5124318A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.R.L. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
JPH0541224Y2 (fr) * 1987-06-08 1993-10-19
US5599686A (en) * 1994-06-28 1997-02-04 Merck & Co., Inc. Peptides
US5866679A (en) * 1994-06-28 1999-02-02 Merck & Co., Inc. Peptides
US6143864A (en) * 1994-06-28 2000-11-07 Merck & Co., Inc. Peptides
BE1008581A3 (fr) * 1994-08-19 1996-06-04 Wallone Region Prodrogues, composition pharmaceutique les comprenant et leur utilisation.
ES2297832T3 (es) * 1994-08-19 2008-05-01 La Region Wallonne Conjugados que comprenden un agente antitumoral y su utilizacion.
JP2543434Y2 (ja) * 1996-04-15 1997-08-06 マツダ株式会社 エンジンの排気管構造
US5998362A (en) * 1996-09-12 1999-12-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US5948750A (en) * 1996-10-30 1999-09-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6391305B1 (en) 1997-09-10 2002-05-21 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US20040081659A1 (en) * 1997-12-02 2004-04-29 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
ZA9810974B (en) * 1997-12-02 1999-06-03 Merck & Co Inc Conjugates useful in the treatment of prostate cancer
CN1181092C (zh) * 1997-12-02 2004-12-22 麦克公司 可用于治疗前列腺癌的缀合物
US6174858B1 (en) 1998-11-17 2001-01-16 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US7425541B2 (en) 1998-12-11 2008-09-16 Medarex, Inc. Enzyme-cleavable prodrug compounds
EP1225918A2 (fr) 1999-10-19 2002-07-31 Merck & Co., Inc. Processus de preparation de conjugues convenant pour le traitement du cancer de la prostate
WO2001030804A2 (fr) 1999-10-27 2001-05-03 Merck & Co., Inc. Sel d'un conjugue utile pour traiter le cancer de la prostate
EP1235598A2 (fr) * 1999-11-12 2002-09-04 Angiotech Pharmaceuticals, Inc. Compositions et methodes destinees au traitement de maladies utilisant une therapie radioactive et des inhibiteurs du cycle cellulaire combines
WO2001095943A2 (fr) 2000-06-14 2001-12-20 Medarex, Inc. Composes de promedicaments contenant de l'isoleucine
WO2002015700A1 (fr) * 2000-08-24 2002-02-28 Coulter Pharmaceutical, Inc. Promedicaments actives par plasmine et leur utilisation en chimiotherapie appliquee au cancer
US20030232760A1 (en) * 2001-09-21 2003-12-18 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US20030216758A1 (en) * 2001-12-28 2003-11-20 Angiotech Pharmaceuticals, Inc. Coated surgical patches
NZ575452A (en) 2002-05-24 2010-03-26 Angiotech Int Ag Compositions and methods for coating medical implants such as vascular grafts, catheters, pacemakers etc
US8313760B2 (en) 2002-05-24 2012-11-20 Angiotech International Ag Compositions and methods for coating medical implants
EP1542739B1 (fr) 2002-09-26 2008-12-10 Angiotech International Ag Enveloppes perivasculaires
ATE457716T1 (de) 2002-12-30 2010-03-15 Angiotech Int Ag Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung
WO2005051444A2 (fr) * 2003-11-20 2005-06-09 Angiotech International Ag Implants pour tissus mous et agents anti-cicatrices
WO2005072061A2 (fr) * 2004-02-02 2005-08-11 Biosight Ltd. Remedes conjugues de therapie et diagnostic du cancer
AU2005100176A4 (en) * 2005-03-01 2005-04-07 Gym Tv Pty Ltd Garbage bin clip
WO2014160037A2 (fr) 2013-03-14 2014-10-02 The Regents Of The University Of California Peptides d'interaction ayant une membrane activables et leurs procédés d'utilisation
US12064445B2 (en) 2015-12-03 2024-08-20 Biosight Ltd. Cytarabine conjugates for cancer therapy
AU2016362239B2 (en) 2015-12-03 2021-03-25 Biosight Ltd. Salts of conjugates for cancer therapy
US12071450B2 (en) 2015-12-03 2024-08-27 Biosight Ltd. Salts of conjugates for cancer therapy
EP3383407B1 (fr) 2015-12-03 2023-12-06 BioSight Ltd. Conjugués de cytarabine pour le traitement du cancer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR7164M (fr) * 1968-02-22 1969-08-04
FR2430425A1 (fr) * 1978-07-07 1980-02-01 Rhone Poulenc Ind Nouveaux derives de la daunorubicine, leur preparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1578734A (fr) * 1967-11-28 1969-08-22
FI51808C (fi) * 1968-07-15 1977-04-12 Rhone Poulenc Sa Menetelmä uusien kasvainten naftaseenijohdannaisten valmistamiseksi.
GB1500421A (en) * 1975-01-22 1978-02-08 Farmaceutici Italia Optically active anthracyclinones
US4012448A (en) * 1976-01-15 1977-03-15 Stanford Research Institute Synthesis of adriamycin and 7,9-epiadriamycin

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR7164M (fr) * 1968-02-22 1969-08-04
FR2430425A1 (fr) * 1978-07-07 1980-02-01 Rhone Poulenc Ind Nouveaux derives de la daunorubicine, leur preparation et les compositions pharmaceutiques qui les contiennent

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6107285A (en) * 1985-08-02 2000-08-22 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside

Also Published As

Publication number Publication date
US4296105A (en) 1981-10-20
FR2432525B1 (fr) 1983-12-02
NL191150B (nl) 1994-09-16
CA1115694A (fr) 1982-01-05
GB2027024A (en) 1980-02-13
GB2027024B (en) 1983-04-27
JPS6259715B2 (fr) 1987-12-12
JPS5522697A (en) 1980-02-18
NL7905953A (nl) 1980-02-05
NL191150C (nl) 1995-02-16

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Legal Events

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