FR2429594A1 - Substance anti-tumorale, son procede de preparation et son application en therapeutique - Google Patents
Substance anti-tumorale, son procede de preparation et son application en therapeutiqueInfo
- Publication number
- FR2429594A1 FR2429594A1 FR7916586A FR7916586A FR2429594A1 FR 2429594 A1 FR2429594 A1 FR 2429594A1 FR 7916586 A FR7916586 A FR 7916586A FR 7916586 A FR7916586 A FR 7916586A FR 2429594 A1 FR2429594 A1 FR 2429594A1
- Authority
- FR
- France
- Prior art keywords
- substance
- preparation
- therapeutic application
- tumor substance
- tumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/46—Streptococcus ; Enterococcus; Lactococcus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/885—Streptococcus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention a pour objet une substance anti-tumorale qui est stable à la chaleur et ne provoque qu'une faible inflammation et une faible douleur. On prépare ces substances par rupture de cellules de bactéries appartenant aux streptocoques hémolytiques, extraction d'une substance insoluble dans l'eau à partir de la matière rompue et traitement de cette substance avec une ou plusieurs protéases et, facultativement, une ou plusieurs nucléases. Utilisation de la substance pour lutter contre les tumeurs chez les mammifères.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7803978A JPS557014A (en) | 1978-06-29 | 1978-06-29 | Antitumor agent and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2429594A1 true FR2429594A1 (fr) | 1980-01-25 |
FR2429594B1 FR2429594B1 (fr) | 1983-04-01 |
Family
ID=13650677
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7916586A Granted FR2429594A1 (fr) | 1978-06-29 | 1979-06-27 | Substance anti-tumorale, son procede de preparation et son application en therapeutique |
Country Status (10)
Country | Link |
---|---|
US (1) | US4242326A (fr) |
JP (1) | JPS557014A (fr) |
CA (1) | CA1135640A (fr) |
CH (1) | CH641354A5 (fr) |
CS (1) | CS235079B2 (fr) |
DE (1) | DE2926406A1 (fr) |
FR (1) | FR2429594A1 (fr) |
GB (1) | GB2025768B (fr) |
IT (1) | IT1119922B (fr) |
SE (1) | SE449439B (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4479935A (en) * | 1980-04-22 | 1984-10-30 | Institut Pasteur | Fractions extracted from aerobic bacteria, endowed with antitumoral, antibacterial and interferon inducing properties, and process for their preparation |
JPS58222026A (ja) * | 1982-06-18 | 1983-12-23 | Masahiro Yoshimura | 抗ガン性物質 |
JPS6169725A (ja) * | 1984-09-13 | 1986-04-10 | Juzo Udaka | 抗腫瘍性物質spf−140及びその製法 |
US4978622A (en) * | 1986-06-23 | 1990-12-18 | Regents Of The University Of California | Cytophaga-derived immunopotentiator |
US5010062A (en) * | 1989-09-25 | 1991-04-23 | Vanderbilt University | Therapeutic agent and method of inhibiting vascularization of tumors |
ES2027518A6 (es) * | 1990-12-18 | 1992-06-01 | Andromaco Lab | Procedimiento para la preparacion de nuevas asociaciones no covalentes polisacarido-proteina con actividad farmacologica. |
US5811403A (en) * | 1996-09-30 | 1998-09-22 | Vanderbilt University | Polysaccharide toxin from Group B β-hemolytic Streptococcus (GBS) having improved purity |
JPH10139670A (ja) * | 1996-11-11 | 1998-05-26 | Terukuni Yakida | インターロイキン12誘導物質及び医薬組成物 |
US6028060A (en) * | 1997-01-29 | 2000-02-22 | Vanderbilt University | Treatment of chronic inflammatory diseases with CM101/GBS toxin |
US5858991A (en) * | 1997-01-29 | 1999-01-12 | Vanderbilt University | Facilitation of wound healing with CM101/GBS toxin |
US5981508A (en) | 1997-01-29 | 1999-11-09 | Vanderbilt University | Facilitation of repair of neural injury with CM101/GBS toxin |
US6670337B1 (en) | 1998-01-29 | 2003-12-30 | Yeda Reaearch And Development Co., Ltd. | Facilitation of wound healing with CM101/GBS toxin |
US8609614B2 (en) * | 1998-07-22 | 2013-12-17 | Vanderbilt University | GBS toxin receptor compositions and methods of use |
US6803448B1 (en) * | 1998-07-22 | 2004-10-12 | Vanderbilt University | GBS toxin receptor |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1163865A (en) * | 1967-02-01 | 1969-09-10 | Kyowa Hakko Kogyo Kk | Process for the preparation of Anti-Tumor Substances |
FR1587689A (fr) * | 1967-08-30 | 1970-03-27 | ||
FR2108094A1 (fr) * | 1970-09-30 | 1972-05-12 | Chugai Pharmaceutical Co Ltd | |
FR2269965A2 (en) * | 1974-05-08 | 1975-12-05 | Wellcome Found | Anti-tumour immuno-stimulating glycopeptide - extd from cell wall of Actinomycetaceae or Mycobacteriaceae bacterium |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1132676A (en) * | 1966-03-08 | 1968-11-06 | Chugai Pharmaceutical Co Ltd | Anti-tumour preparation and process for preparing the same |
GB1153113A (en) * | 1967-01-20 | 1969-05-21 | Chugai Pharmaceutical Co Ltd | Method of Treating Hemolytic Streptococci and the Resultant Preparation containing the same |
JPS4843841B1 (fr) * | 1969-09-06 | 1973-12-21 |
-
1978
- 1978-06-29 JP JP7803978A patent/JPS557014A/ja active Granted
-
1979
- 1979-06-14 GB GB7920677A patent/GB2025768B/en not_active Expired
- 1979-06-18 US US06/049,744 patent/US4242326A/en not_active Expired - Lifetime
- 1979-06-22 IT IT68342/79A patent/IT1119922B/it active
- 1979-06-26 CA CA000330751A patent/CA1135640A/fr not_active Expired
- 1979-06-27 FR FR7916586A patent/FR2429594A1/fr active Granted
- 1979-06-28 SE SE7905703A patent/SE449439B/sv not_active IP Right Cessation
- 1979-06-28 CS CS794488A patent/CS235079B2/cs unknown
- 1979-06-29 DE DE19792926406 patent/DE2926406A1/de active Granted
- 1979-06-29 CH CH611479A patent/CH641354A5/de not_active IP Right Cessation
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1163865A (en) * | 1967-02-01 | 1969-09-10 | Kyowa Hakko Kogyo Kk | Process for the preparation of Anti-Tumor Substances |
FR7480M (fr) * | 1967-02-01 | 1969-12-01 | ||
FR1587689A (fr) * | 1967-08-30 | 1970-03-27 | ||
GB1189935A (en) * | 1967-08-30 | 1970-04-29 | Chugai Pharmaceutical Co Ltd | Dried Stable Anti-Tumour Preparations and a process for preparing the same |
FR8144M (fr) * | 1967-08-30 | 1970-08-17 | ||
FR2108094A1 (fr) * | 1970-09-30 | 1972-05-12 | Chugai Pharmaceutical Co Ltd | |
FR2269965A2 (en) * | 1974-05-08 | 1975-12-05 | Wellcome Found | Anti-tumour immuno-stimulating glycopeptide - extd from cell wall of Actinomycetaceae or Mycobacteriaceae bacterium |
Also Published As
Publication number | Publication date |
---|---|
CH641354A5 (de) | 1984-02-29 |
FR2429594B1 (fr) | 1983-04-01 |
DE2926406A1 (de) | 1980-01-10 |
JPS6169B2 (fr) | 1986-01-06 |
SE449439B (sv) | 1987-05-04 |
GB2025768B (en) | 1982-11-24 |
US4242326A (en) | 1980-12-30 |
CS235079B2 (en) | 1985-04-16 |
JPS557014A (en) | 1980-01-18 |
IT7968342A0 (it) | 1979-06-22 |
SE7905703L (sv) | 1979-12-30 |
CA1135640A (fr) | 1982-11-16 |
IT1119922B (it) | 1986-03-19 |
GB2025768A (en) | 1980-01-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |