FR2426736A1 - Nebramycin antibiotic complex microbiological prodn. - by cultivation of nebramycin-resistant strains of Streptomyces tenebrarius - Google Patents

Nebramycin antibiotic complex microbiological prodn. - by cultivation of nebramycin-resistant strains of Streptomyces tenebrarius

Info

Publication number
FR2426736A1
FR2426736A1 FR7912950A FR7912950A FR2426736A1 FR 2426736 A1 FR2426736 A1 FR 2426736A1 FR 7912950 A FR7912950 A FR 7912950A FR 7912950 A FR7912950 A FR 7912950A FR 2426736 A1 FR2426736 A1 FR 2426736A1
Authority
FR
France
Prior art keywords
nebramycin
prodn
complex
strains
streptomyces tenebrarius
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7912950A
Other languages
French (fr)
Other versions
FR2426736B1 (en
Inventor
Istvan Ott
Gabor Ambrus
Jozsef Gyimesi
Ilona Harsanyi
Janos Berdy
Valeria Szell
Tibor Balogh
Laszlo Tolgyesi
I Kadar
Laszlo Nagy
Janos Erdey
E Szucs
Istvan Kaszab
Ferenc Fabian
Kalman Polya
Lajos Kun
Janos Vig
Jeno Szilagyi
Csaba Nagy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Hungary Pharmaceutical Marketing PLC
Original Assignee
Institute for Drugs Research Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute for Drugs Research Ltd filed Critical Institute for Drugs Research Ltd
Publication of FR2426736A1 publication Critical patent/FR2426736A1/en
Application granted granted Critical
Publication of FR2426736B1 publication Critical patent/FR2426736B1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/46—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin
    • C12P19/48—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin the cyclohexyl radical being substituted by two or more nitrogen atoms, e.g. destomycin, neamin
    • C12P19/485—Having two saccharide radicals bound through only oxygen to non-adjacent ring carbons of the cyclohexyl radical, e.g. gentamycin, kanamycin, sisomycin, verdamycin, mutamycin, tobramycin, nebramycin, antibiotics 66-40B, 66-40D, XK-62-2, 66-40, G-418, G-52
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

In a new process for the microbioglical prodn. of the nebramycin complex, (a) a strain of Streptomyces tenebrarius which biosynthesises the nebramycin complex is cultivated in a nutrient medium contg. nebramycin 2, nebramycin 5' and/or nebramycin 6 and the individuals forming growing aerial mycelium and spores in the presence of 10-30 mg ml of these antibiotics are isolated; (b) the resulting new resistant strains are cultivated in a submerged aerobic culture in a nutrient medium contg. N- and C- sources, inorganic salts and (opt.) vegetable and/or animal fats at 30-42 degrees C (pref. 35-38 degrees C); and the nebramycin complex or nebramycin 2, nebramycin 4 and nebramycin 5' accumulating in the medium is isolated. Nebramycin 2 (apramycin) is used in the treatment of diseases of animals and plants (cf. US 3691279, 3853709, 3876767). Nebramycin 6 (tobramycin), produced by hydrolysis of nebramycin 5' (6"-O-carbamoyl-tobramycin), is a broad-spectrum antibiotic used in human medicine, esp. against polyresistant Pseudomonas strains. Use of selected nebramycin-resistant Streptomyces tenebrarius strains allows the prodn. of cultures with high nebramycin concns. thus giving improved yields.
FR7912950A 1978-05-23 1979-05-22 PROCESS FOR MANUFACTURING NEBRAMYCIN COMPLEX BY MICROBIOLOGICALLY Expired FR2426736B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU78GO1404A HU176103B (en) 1978-05-23 1978-05-23 Microbiological process for producing nebramycin complex

Publications (2)

Publication Number Publication Date
FR2426736A1 true FR2426736A1 (en) 1979-12-21
FR2426736B1 FR2426736B1 (en) 1985-08-09

Family

ID=10996858

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7912950A Expired FR2426736B1 (en) 1978-05-23 1979-05-22 PROCESS FOR MANUFACTURING NEBRAMYCIN COMPLEX BY MICROBIOLOGICALLY

Country Status (4)

Country Link
AT (1) AT363180B (en)
DE (1) DE2921022A1 (en)
FR (1) FR2426736B1 (en)
HU (1) HU176103B (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3691279A (en) * 1970-04-15 1972-09-12 Lilly Co Eli Antibiotic nebramycin and preparation thereof
US3853709A (en) * 1970-10-26 1974-12-10 Lilly Co Eli Process for preparing nebramycin factors ii and vii
US4032404A (en) * 1976-07-14 1977-06-28 Bristol-Myers Company Fermentation process for producing apramycin and nebramycin factor V'

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1178489A (en) * 1967-04-04 1970-01-21 Lilly Co Eli Tenebrimycin Antibiotics
US3876767A (en) * 1972-02-04 1975-04-08 Lilly Co Eli Treatment of swine dysentery with apramycin

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3691279A (en) * 1970-04-15 1972-09-12 Lilly Co Eli Antibiotic nebramycin and preparation thereof
US3853709A (en) * 1970-10-26 1974-12-10 Lilly Co Eli Process for preparing nebramycin factors ii and vii
US4032404A (en) * 1976-07-14 1977-06-28 Bristol-Myers Company Fermentation process for producing apramycin and nebramycin factor V'

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, volume 86, no. 15, 11 avril 1977, page 341, abrégé 104393x (COLUMBUS OHIO, US) & Dev. Ind. Microbiol. 1976, 17, 61-77; W.M. STARK et al. "The nebramycin fermentation: culture and fermentation development" *
H. UMEZAWA "Index of antibiotics from actinomycetes", volume II, Japan Scientific Societies Press, 1978 (TOKYO, JP) "Nebramycin complex", page 737 *
H. UMEZAWA "Index of antibiotics from actinomycetes", volume II, Japan Scientific Societies Press, 1978 (TOKYO, JP) "Nebramycin factor 4", page 738 *
H. UMEZAWA "Index of antibiotics from actinomycetes", volume II, Japan Scientific Societies Press, 1978 (TOKYO, JP) "Nebramycin factor 5'", page 739 *

Also Published As

Publication number Publication date
AT363180B (en) 1981-07-10
DE2921022C2 (en) 1987-10-15
ATA357279A (en) 1980-12-15
FR2426736B1 (en) 1985-08-09
HU176103B (en) 1980-12-28
DE2921022A1 (en) 1979-11-29

Similar Documents

Publication Publication Date Title
DE3163243D1 (en) Process for the production of a bacterial preparation for the prophylaxis of intestinal disturbances in poultry
Wensinck et al. The intestinal flora of colonization-resistant mice
EP0311194A3 (en) Process for antifungal fermentation product and culture
NO932327D0 (en) PSEUDOMONAS AERUGINOSA AND ITS APPLICATIONS IN PROCEDURES FOR BIOTECHNOLOGICAL PREPARATION OF L-RHAMNOSE
SE8800991D0 (en) PROCESS FOR PREPARING ALGAE HAVING IMPROVED BIOLOGICAL EFFECTS
Thom Mycology presents penicillin
DE3686158D1 (en) VACCINE AGAINST MASTITIS.
ES2149821T3 (en) LEUCOTOXOID VACCINE OF FUSOBACTERIUM NECROPHORUM.
Holst An antibiotic from a bee pathogen
FR2426736A1 (en) Nebramycin antibiotic complex microbiological prodn. - by cultivation of nebramycin-resistant strains of Streptomyces tenebrarius
Skinner et al. The utilization of nitrogenous organic compounds and sodium salts of organic acids by certain soil algae in darkness and in the light
Fitzsimons et al. The isolation and growth of axenic cultures of planktonic blue—green algae
PT759981E (en) METHOD OF CULTURE OF BACTERIA PRODUCING PROTEINS THAT ARE EXPRESSED IN A MODE REGULATED BY TEMPERATURE
Shapiro et al. Lactobacilli in the intestinal tract of the chicken
ATE4212T1 (en) ANTIBIOTIC FOR THE SUPRESSION OF THE GROWTH OF MICROORGANISMS AND THEIR PRODUCTION BY FERMENTATION.
SE7612293L (en) ANTIBIOTIC
Sakata et al. Antibiotic production by marine pigmented bacteria-I
JPH06122607A (en) Method for controlling blight and promoting growth of solution-culture plant
UMEZAWA et al. On the new source of chloromycetin, Streptomyces omiyaensis
RU2179392C1 (en) Strain of bacterium bacillus thuringiensis varietas kurstaki vkm v-2248d used for entomopathogenic preparation preparing
Hawley et al. Microbiologic Therapy of Tuberculosis: Bacterium termo to Streptomyces griseus
SU699016A1 (en) Bacillus thuringiensis var.dindro limus c-5 straindendrobacillin producent
Ajemian Production of a Toxin-Neutralizing Substance by Penicillium Cyaneo-Fulvum.
Waksman Microbiology in the USS R. in 1946
SU1514776A1 (en) Method of producing endo-1,4-beta-mannanase

Legal Events

Date Code Title Description
ST Notification of lapse