FR2426686A1 - Acides phenylaminothiophene-acetiques, leurs procedes de fabrication et medicaments les contenant - Google Patents

Acides phenylaminothiophene-acetiques, leurs procedes de fabrication et medicaments les contenant

Info

Publication number
FR2426686A1
FR2426686A1 FR7913082A FR7913082A FR2426686A1 FR 2426686 A1 FR2426686 A1 FR 2426686A1 FR 7913082 A FR7913082 A FR 7913082A FR 7913082 A FR7913082 A FR 7913082A FR 2426686 A1 FR2426686 A1 FR 2426686A1
Authority
FR
France
Prior art keywords
phenylaminothiophene
acetic acids
manufacturing methods
products containing
medicinal products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7913082A
Other languages
English (en)
Other versions
FR2426686B1 (fr
Inventor
Volker Figala
Georg Rainer
Richard Riedel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Byk Gulden Lomberg Chemische Fabrik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik GmbH filed Critical Byk Gulden Lomberg Chemische Fabrik GmbH
Publication of FR2426686A1 publication Critical patent/FR2426686A1/fr
Application granted granted Critical
Publication of FR2426686B1 publication Critical patent/FR2426686B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Acides phénylaminothiophène-acétiques de formule générale I ainsi que leurs sels, de préférence pharmacologiquement compatibles, dans laquelle R**1, R**2, R**3, R**4, R**5 et **6 ont la signification indiquée dans la description. Procédés de préparation de ces composés par lyolyse de dérivés fonctionnels d'acides carboxyliques de formule générale II. Application à la préparation de médicaments doués d'une activité antiphlogistique, analgésique et antipyrétique très marquées.
FR7913082A 1978-05-24 1979-05-23 Acides phenylaminothiophene-acetiques, leurs procedes de fabrication et medicaments les contenant Granted FR2426686A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH568778 1978-05-24
CH341979 1979-04-10

Publications (2)

Publication Number Publication Date
FR2426686A1 true FR2426686A1 (fr) 1979-12-21
FR2426686B1 FR2426686B1 (fr) 1980-12-12

Family

ID=25692954

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7913082A Granted FR2426686A1 (fr) 1978-05-24 1979-05-23 Acides phenylaminothiophene-acetiques, leurs procedes de fabrication et medicaments les contenant

Country Status (17)

Country Link
US (1) US4272507A (fr)
EP (1) EP0005559B1 (fr)
AU (1) AU522119B2 (fr)
CA (1) CA1132585A (fr)
DE (2) DE2961218D1 (fr)
DK (1) DK157020C (fr)
ES (1) ES480827A1 (fr)
FR (1) FR2426686A1 (fr)
GB (1) GB2021584B (fr)
HU (1) HU181648B (fr)
IE (1) IE48508B1 (fr)
IL (1) IL57360A (fr)
MY (1) MY8600270A (fr)
NZ (1) NZ190521A (fr)
PT (1) PT69655A (fr)
SG (1) SG70185G (fr)
YU (1) YU118379A (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH672888A5 (fr) * 1986-11-07 1990-01-15 Mepha Ag
ES2095831T3 (es) * 1988-04-22 1997-03-01 Byk Gulden Lomberg Chem Fab Acidos tetrahidro-4-fenilimino-3-tiofeno-aceticos.
EP0338494B1 (fr) * 1988-04-22 1996-01-10 Byk Gulden Lomberg Chemische Fabrik GmbH Acides 3-anilino-2-hydroxycarbonyl-4-thiophène-acétiques
GR900100380A (el) * 1989-05-20 1991-10-10 Fisons Plc Μέ?οδος παρασκευής αντι-φλεγμονωδών παραγώγων αμινοφενόλης.
US5556863A (en) * 1993-06-11 1996-09-17 Astra Aktiebolag Compound for gastric acid secretion inhibition
IS4164A (is) * 1993-06-11 1994-12-12 Ab Astra Efnasambönd sem hindra flæði magasýru
US6858223B2 (en) * 1998-06-23 2005-02-22 Altana Pharma Ag Compositions comprising phenylaminothiophenacetic acid derivatives for the treatment of acute or adult respiratory distress syndrome (ARDS) and infant respiratory distress syndrome (IRDS)
DE19827907C2 (de) * 1998-06-23 2003-05-15 Altana Pharma Ag Neue pharmazeutische Zusammensetzungen zur Behandlung von IRDS und ARDS
DE602004018276D1 (de) * 2003-02-19 2009-01-22 Nycomed Gmbh Nitratester von phenylaminothiophen-essigsäurederivaten
EP2508511A1 (fr) 2011-04-07 2012-10-10 Laboratoire Biodim Inhibiteurs de la réplication virale, leur procédé de préparation et leurs utilisations thérapeutiques

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5539M (fr) * 1965-04-10 1967-11-13

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5539M (fr) * 1965-04-10 1967-11-13

Also Published As

Publication number Publication date
US4272507A (en) 1981-06-09
GB2021584A (en) 1979-12-05
CA1132585A (fr) 1982-09-28
FR2426686B1 (fr) 1980-12-12
DK157020B (da) 1989-10-30
HU181648B (en) 1983-10-28
IE790996L (en) 1979-11-24
AU4728579A (en) 1979-11-29
GB2021584B (en) 1982-09-22
SG70185G (en) 1989-09-29
NZ190521A (en) 1980-10-08
EP0005559A1 (fr) 1979-11-28
DK215079A (da) 1979-11-25
ES480827A1 (es) 1979-12-01
IE48508B1 (en) 1985-02-20
IL57360A (en) 1982-08-31
EP0005559B1 (fr) 1981-11-04
DK157020C (da) 1990-03-26
DE2920861A1 (de) 1979-11-29
PT69655A (de) 1979-06-01
AU522119B2 (en) 1982-05-20
DE2961218D1 (en) 1982-01-14
MY8600270A (en) 1986-12-31
YU118379A (en) 1983-02-28
IL57360A0 (en) 1979-09-30

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