FR2424285A1 - Procede microbiologique de preparation de glycosides antibiotiques et substances medicamenteuses - Google Patents
Procede microbiologique de preparation de glycosides antibiotiques et substances medicamenteusesInfo
- Publication number
- FR2424285A1 FR2424285A1 FR7903099A FR7903099A FR2424285A1 FR 2424285 A1 FR2424285 A1 FR 2424285A1 FR 7903099 A FR7903099 A FR 7903099A FR 7903099 A FR7903099 A FR 7903099A FR 2424285 A1 FR2424285 A1 FR 2424285A1
- Authority
- FR
- France
- Prior art keywords
- glycosides
- antibiotic
- preparation
- medicinal substances
- microbiological process
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229930182470 glycoside Natural products 0.000 title abstract 2
- 150000002338 glycosides Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000003115 biocidal effect Effects 0.000 title 1
- 230000002906 microbiologic effect Effects 0.000 title 1
- 239000000126 substance Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000855 fermentation Methods 0.000 abstract 2
- 230000004151 fermentation Effects 0.000 abstract 2
- VZUNGTLZRAYYDE-UHFFFAOYSA-N N-methyl-N'-nitro-N-nitrosoguanidine Chemical compound O=NN(C)C(=N)N[N+]([O-])=O VZUNGTLZRAYYDE-UHFFFAOYSA-N 0.000 abstract 1
- 241000187081 Streptomyces peucetius Species 0.000 abstract 1
- 229940045799 anthracyclines and related substance Drugs 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 230000000975 bioactive effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 231100000219 mutagenic Toxicity 0.000 abstract 1
- 230000003505 mutagenic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB524678 | 1978-02-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2424285A1 true FR2424285A1 (fr) | 1979-11-23 |
| FR2424285B1 FR2424285B1 (OSRAM) | 1982-06-11 |
Family
ID=9792470
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7903099A Granted FR2424285A1 (fr) | 1978-02-09 | 1979-02-07 | Procede microbiologique de preparation de glycosides antibiotiques et substances medicamenteuses |
| FR7924203A Granted FR2429770A1 (fr) | 1978-02-09 | 1979-09-28 | Aglycones derivant de glycosides d'anthracycline et procede pour les preparer |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7924203A Granted FR2429770A1 (fr) | 1978-02-09 | 1979-09-28 | Aglycones derivant de glycosides d'anthracycline et procede pour les preparer |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4247545A (OSRAM) |
| JP (1) | JPS54115363A (OSRAM) |
| BE (1) | BE874032A (OSRAM) |
| CH (1) | CH640246A5 (OSRAM) |
| DE (1) | DE2904186C2 (OSRAM) |
| FR (2) | FR2424285A1 (OSRAM) |
| GB (1) | GB2016005B (OSRAM) |
| NL (1) | NL7900869A (OSRAM) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0044954A3 (en) * | 1980-07-18 | 1982-03-17 | F. Hoffmann-La Roche & Co. Aktiengesellschaft | Anthracyclinglycosides, their preparation and intermediates, and pharmaceutical preparations |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4411834A (en) * | 1978-02-09 | 1983-10-25 | Farmitalia Carlo Erba, S.P.A. | Preparation of II-deoxy anthracycline antibiotics |
| NL7900869A (nl) | 1978-02-09 | 1979-08-13 | Erba Farmitalia | Anthracyclinenantibiotica. |
| IT1196402B (it) * | 1978-11-21 | 1988-11-16 | Erba Farmitalia | Antibiotici antitumorali |
| ATE4387T1 (de) * | 1979-07-04 | 1983-08-15 | Farmitalia Carlo Erba S.P.A. | Anthracyclin-glycoside, verfahren zu ihrer herstellung und sie enthaltende therapeutische zusammensetzung. |
| ZA814722B (en) * | 1980-07-18 | 1982-07-28 | Hoffmann La Roche | Novel anthracycline glycosides |
| JPS5756494A (en) * | 1980-09-22 | 1982-04-05 | Microbial Chem Res Found | New anthracyclin derivative |
| IT1210476B (it) * | 1981-05-28 | 1989-09-14 | Erba Farmitalia | Antracicline. |
| US4563444A (en) * | 1982-05-26 | 1986-01-07 | Farmitalia Carlo Erba S.P.A. | Anthracycline glycosides, use and compositions containing same |
| US5948896A (en) * | 1997-08-13 | 1999-09-07 | Gem Pharmaceuticals | Processes for preparing 13-deoxy anthracycline derivatives |
| US5942605A (en) * | 1998-03-03 | 1999-08-24 | Gem Pharmaceuticals, Inc. | 5-imino-13-deoxy anthracycline derivatives, their uses, and processes for preparing them |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR7406M (fr) * | 1967-04-18 | 1969-11-03 | Farmaceutici Italia | Substance antibiotique, ses derives et leur procede de preparation |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3976667A (en) * | 1975-06-19 | 1976-08-24 | The Upjohn Company | Steffimycinone, 7-deoxysteffimycinone and derivatives |
| US4039736A (en) * | 1976-04-15 | 1977-08-02 | Bristol-Myers Company | Antibiotic compounds marcellomycin and musettamycin |
| US4064340A (en) * | 1976-12-09 | 1977-12-20 | The Upjohn Company | Nogamycin and process of preparation |
| NL7900869A (nl) | 1978-02-09 | 1979-08-13 | Erba Farmitalia | Anthracyclinenantibiotica. |
-
1979
- 1979-02-02 NL NL7900869A patent/NL7900869A/xx not_active Application Discontinuation
- 1979-02-05 GB GB7903901A patent/GB2016005B/en not_active Expired
- 1979-02-05 DE DE2904186A patent/DE2904186C2/de not_active Expired
- 1979-02-05 US US06/009,650 patent/US4247545A/en not_active Expired - Lifetime
- 1979-02-07 FR FR7903099A patent/FR2424285A1/fr active Granted
- 1979-02-08 CH CH124779A patent/CH640246A5/de not_active IP Right Cessation
- 1979-02-08 BE BE0/193347A patent/BE874032A/xx not_active IP Right Cessation
- 1979-02-08 JP JP1285079A patent/JPS54115363A/ja active Pending
- 1979-09-28 FR FR7924203A patent/FR2429770A1/fr active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR7406M (fr) * | 1967-04-18 | 1969-11-03 | Farmaceutici Italia | Substance antibiotique, ses derives et leur procede de preparation |
Non-Patent Citations (1)
| Title |
|---|
| EXBK/77 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0044954A3 (en) * | 1980-07-18 | 1982-03-17 | F. Hoffmann-La Roche & Co. Aktiengesellschaft | Anthracyclinglycosides, their preparation and intermediates, and pharmaceutical preparations |
| EP0106996A1 (de) * | 1980-07-18 | 1984-05-02 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | 3,5,12-Trihydroxy-6,11-dioxonaphthacene |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2429770B1 (OSRAM) | 1984-07-27 |
| GB2016005A (en) | 1979-09-19 |
| FR2429770A1 (fr) | 1980-01-25 |
| GB2016005B (en) | 1982-06-16 |
| CH640246A5 (de) | 1983-12-30 |
| BE874032A (fr) | 1979-08-08 |
| FR2424285B1 (OSRAM) | 1982-06-11 |
| DE2904186C2 (de) | 1984-09-06 |
| US4247545A (en) | 1981-01-27 |
| JPS54115363A (en) | 1979-09-07 |
| NL7900869A (nl) | 1979-08-13 |
| DE2904186A1 (de) | 1979-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |