FR2294185A1 - Procede de preparation de l'a-epoxy-3',4' neamine et des derives d'antibiotiques aminoglycosodiques apparentes et nouveaux composes ainsi prepares - Google Patents

Procede de preparation de l'a-epoxy-3',4' neamine et des derives d'antibiotiques aminoglycosodiques apparentes et nouveaux composes ainsi prepares

Info

Publication number
FR2294185A1
FR2294185A1 FR7538758A FR7538758A FR2294185A1 FR 2294185 A1 FR2294185 A1 FR 2294185A1 FR 7538758 A FR7538758 A FR 7538758A FR 7538758 A FR7538758 A FR 7538758A FR 2294185 A1 FR2294185 A1 FR 2294185A1
Authority
FR
France
Prior art keywords
aminoglycosodium
neamine
epoxy
prepared
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7538758A
Other languages
English (en)
Other versions
FR2294185B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Seika Kaisha Ltd
Original Assignee
Meiji Seika Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha Ltd filed Critical Meiji Seika Kaisha Ltd
Publication of FR2294185A1 publication Critical patent/FR2294185A1/fr
Application granted granted Critical
Publication of FR2294185B1 publication Critical patent/FR2294185B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
    • C07H15/23—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with only two saccharide radicals in the molecule, e.g. ambutyrosin, butyrosin, xylostatin, ribostamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR7538758A 1974-12-11 1975-12-10 Procede de preparation de l'a-epoxy-3',4' neamine et des derives d'antibiotiques aminoglycosodiques apparentes et nouveaux composes ainsi prepares Granted FR2294185A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP49141498A JPS5850235B2 (ja) 1974-12-11 1974-12-11 ３′，４′−α−エポキシ−リボスタマイシン又は−カナマイシンＢの製造法

Publications (2)

Publication Number Publication Date
FR2294185A1 true FR2294185A1 (fr) 1976-07-09
FR2294185B1 FR2294185B1 (fr) 1979-02-02

Family

ID=15293326

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7538758A Granted FR2294185A1 (fr) 1974-12-11 1975-12-10 Procede de preparation de l'a-epoxy-3',4' neamine et des derives d'antibiotiques aminoglycosodiques apparentes et nouveaux composes ainsi prepares

Country Status (5)

Country Link
US (1) US4078138A (fr)
JP (1) JPS5850235B2 (fr)
DE (1) DE2555479A1 (fr)
FR (1) FR2294185A1 (fr)
GB (1) GB1522818A (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2481290A1 (fr) * 1980-04-25 1981-10-30 Microbial Chem Res Found Nouveau procede de preparation de la 3'-desoxykanamycine a

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4189569A (en) * 1976-09-08 1980-02-19 Abbott Laboratories Seldomycin factor 5 derivatives
GB1567392A (en) * 1977-02-22 1980-05-14 Farmaceutici Italia Daunorubicin derivatives
US4252970A (en) * 1977-09-06 1981-02-24 The Upjohn Company 6-Deoxyneamines
US4214075A (en) * 1977-12-21 1980-07-22 Abbott Laboratories 6'-Epi-fortimicin A and B derivatives
US4226980A (en) * 1978-12-07 1980-10-07 Abbott Laboratories Novel derivatives of fortimicin B and process for preparing same
US4218442A (en) * 1979-03-29 1980-08-19 Abbott Laboratories 1-Epi-fortimicin A and derivatives
ZA803031B (en) * 1979-06-07 1981-05-27 Erba Farmitalia Paromomycin derivatives
BE886393A (fr) * 1980-01-30 1981-03-16 Erba Farmitalia Derives de paromomycine
JPS56118097A (en) * 1980-02-25 1981-09-16 Microbial Chem Res Found Kanamycin a derivative and its preparation
JPS5815994A (ja) * 1981-07-22 1983-01-29 Microbial Chem Res Found ２′位修飾カナマイシン誘導体およびその製造法
CA2632968A1 (fr) * 2005-12-02 2007-06-07 Isis Pharmaceuticals, Inc. Analogues d'aminoglycoside 4,5-substitues antibacteriens comportant plusieurs substituants
EP2148884A1 (fr) * 2007-04-10 2010-02-03 Achaogen, Inc. Analogues de l'aminoglycoside 1,4,5-substitué antibactérien
WO2010030704A2 (fr) 2008-09-10 2010-03-18 Achaogen, Inc. Analogues d’aminoglycosides antibactériens
WO2010030690A1 (fr) 2008-09-10 2010-03-18 Isis Pharmaceuticals, Inc. Analogues d'aminoglycosides 4,6-substitués et modifiés aux positions 6',6" et 1 possédant une activité antibactérienne
WO2010042850A1 (fr) 2008-10-09 2010-04-15 Achaogen, Inc. Analogues d'aminoglycoside antibactériens
WO2010042851A1 (fr) 2008-10-09 2010-04-15 Achaogen, Inc. Analogues d’aminoglycoside antibactériens
JP2013507391A (ja) 2009-10-09 2013-03-04 アカオジェン インコーポレイテッド 抗ウイルスアミノグリコシド類似体
WO2012067978A1 (fr) 2010-11-17 2012-05-24 Achaogen, Inc. Analogues d'aminoglycosides antibactériens

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3929762A (en) * 1972-08-23 1975-12-30 Microbial Chem Res Found 3{40 -Deoxy derivatives of neamine and its related aminoglycosidic antibiotics, and the production thereof
US3920628A (en) * 1972-10-24 1975-11-18 Schering Corp 2{41 -Deoxyaminoglycosides and 2{41 -epi-amino-3{41 -desamino derivatives thereof, methods for their manufacture and novel intermediates useful therein

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HETEROCYCLIC COMPOUNDS, 19 1 A. WEISSBERGER INTERSCIENCE PUBLISHERS 1964 .) *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2481290A1 (fr) * 1980-04-25 1981-10-30 Microbial Chem Res Found Nouveau procede de preparation de la 3'-desoxykanamycine a

Also Published As

Publication number Publication date
JPS5168542A (en) 1976-06-14
DE2555479A1 (de) 1976-06-24
JPS5850235B2 (ja) 1983-11-09
GB1522818A (en) 1978-08-31
FR2294185B1 (fr) 1979-02-02
US4078138A (en) 1978-03-07

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Legal Events

Date Code Title Description
ST Notification of lapse