FR2421906A2 - NEW OXIMES DERIVED FROM 3-ACETOXY METHYL 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS - Google Patents

NEW OXIMES DERIVED FROM 3-ACETOXY METHYL 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS

Info

Publication number
FR2421906A2
FR2421906A2 FR7736512A FR7736512A FR2421906A2 FR 2421906 A2 FR2421906 A2 FR 2421906A2 FR 7736512 A FR7736512 A FR 7736512A FR 7736512 A FR7736512 A FR 7736512A FR 2421906 A2 FR2421906 A2 FR 2421906A2
Authority
FR
France
Prior art keywords
amino
imino
oxy
acetyl
acetoxymethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7736512A
Other languages
French (fr)
Other versions
FR2421906B2 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR7736512A priority Critical patent/FR2421906A2/en
Priority to SE7802833A priority patent/SE439312B/en
Priority to US05/886,421 priority patent/US4288434A/en
Priority to SU782588855A priority patent/SU882412A3/en
Priority to HU78RO972A priority patent/HU182567B/en
Priority to DK129578A priority patent/DK159156C/en
Priority to ES468169A priority patent/ES468169A1/en
Priority to DE2858771A priority patent/DE2858771C2/de
Priority to DE19782812625 priority patent/DE2812625A1/en
Priority to NL7803166A priority patent/NL192041C/en
Priority to PT67815A priority patent/PT67815A/en
Priority to CH1361/84A priority patent/CH648555A5/en
Priority to GB11613/78A priority patent/GB1605175A/en
Priority to CH322978A priority patent/CH633292A5/en
Priority to CA299,661A priority patent/CA1125280A/en
Priority to GB16825/80A priority patent/GB1605176A/en
Priority to AU34471/78A priority patent/AU520657B2/en
Priority to IT48604/78A priority patent/IT1103478B/en
Priority to JP3319378A priority patent/JPS53119887A/en
Priority to LU79312A priority patent/LU79312A1/en
Priority to PH20927A priority patent/PH15764A/en
Priority to AT218378A priority patent/AT360153B/en
Priority to IE604/78A priority patent/IE47361B1/en
Priority to IE1518/83A priority patent/IE47362B1/en
Priority to GB307781A priority patent/GB1605177A/en
Priority to ES477592A priority patent/ES477592A1/en
Priority to AT607579A priority patent/AT361122B/en
Publication of FR2421906A2 publication Critical patent/FR2421906A2/en
Priority to AT331380A priority patent/AT376215B/en
Priority to US06/260,311 priority patent/US4386210A/en
Priority to CA379,842A priority patent/CA1132575A/en
Priority to CH386882A priority patent/CH639652A5/en
Priority to US06/469,710 priority patent/US4487937A/en
Priority to SE8304239A priority patent/SE453192B/en
Priority to CH644383A priority patent/CH646159A5/en
Priority to US06/574,876 priority patent/US4483981A/en
Application granted granted Critical
Publication of FR2421906B2 publication Critical patent/FR2421906B2/fr
Priority to JP63152471A priority patent/JPS6425768A/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Les produits répondant à la formule du brevet principal dont les noms suivent : le 3-acétoxyméthyl 7-//2-(2-tritylamino thiazol 4-yl) 2-//(cyanométhyl)oxy/imino/acétyl/amino/ceph3-ème 4-carboxylate de tert-butyle isomère syn, l'acide 3-acétoxyméthyl 7-//2-(2-amino thiazol 4-yl)2-//(cyanométhyl)oxy/imino/acétyl/amino/ceph-3-ème 4-carboxylique isomere syn et son sel de sodium, le 3-acétoxyméthyl 7-//2-(2-triylaminothiazol 4-yl) 2-///(aminocarbonyl)méthyl/oxy/imino/acétyl/amino/ceph-3-ème 4-carboxylate de tert-butyle isomère syn, l'acide 3-acétoxyméthyl 7-//2-(2-amino thiazol 4-yl) 2-///(aminocarbonyl)méthyl/oxy/imino/acétyl/amino/ceph-3-ème 4-carboxylique isomère syn et son sel de sodium, le 3-acétoxyméthyl 7-//2-(2-tritylamino thiazol 4-yl) 2-//(1-tertbutoxycarbonyl 1-méthyl éthyl)oxy/imino/acétyl/amino/ceph-3-ème 4-carboylate de tert-butyle isomère syn, l'acide 3-acétoxyméthyl 7-//2-(2-amino 4-thiazolyl) 2-//(1-carboxy 1-méthyl éthyl)oxy/imino/acétyl/amino/ceph-3-ème 4-carboxylique isomère syn et son sel disodique. Variante du procédé décrit au brevet principal et application à titre de médicaments des produits.The products corresponding to the formula of the main patent, the names of which follow: 3-acetoxymethyl 7 - // 2- (2-tritylamino thiazol 4-yl) 2 - // (cyanomethyl) oxy / imino / acetyl / amino / ceph3- th tert-butyl 4-carboxylate isomer syn, 3-acetoxymethyl acid 7 - // 2- (2-amino thiazol 4-yl) 2 - // (cyanomethyl) oxy / imino / acetyl / amino / ceph-3 -th 4-carboxylic isomer syn and its sodium salt, 3-acetoxymethyl 7 - // 2- (2-triylaminothiazol 4-yl) 2 - /// (aminocarbonyl) methyl / oxy / imino / acetyl / amino / ceph -3-t-butyl 4-carboxylate isomer syn, 3-acetoxymethyl acid 7 - // 2- (2-amino thiazol 4-yl) 2 - /// (aminocarbonyl) methyl / oxy / imino / acetyl / amino / ceph-3-rd 4-carboxylic isomer syn and its sodium salt, 3-acetoxymethyl 7 - // 2- (2-tritylamino thiazol 4-yl) 2 - // (1-tertbutoxycarbonyl 1-methyl ethyl ) oxy / imino / acetyl / amino / ceph-3-rd 4-carboylate tert-butyl isomer syn, 3-acetoxymethyl acid 7 - // 2- (2-amino 4-thiazolyl) 2 - // (1 -carboxy 1-methyl ethyl) oxy / imino / acetyl / amino / ceph-3-rd 4-carboxylic iso mother syn and her disodium salt. Variant of the process described in the main patent and application as medicinal products.

FR7736512A 1977-03-25 1977-12-05 NEW OXIMES DERIVED FROM 3-ACETOXY METHYL 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS Granted FR2421906A2 (en)

Priority Applications (36)

Application Number Priority Date Filing Date Title
FR7736512A FR2421906A2 (en) 1977-12-05 1977-12-05 NEW OXIMES DERIVED FROM 3-ACETOXY METHYL 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS
SE7802833A SE439312B (en) 1977-03-25 1978-03-13 SET TO MAKE NEW OXIME DERIVATIVES OF 3-ACETOXIMETHYL-7-AMINOTIAZOLYLACETAMIDO CEPHALOSPORANIC ACID
SU782588855A SU882412A3 (en) 1977-12-05 1978-03-14 Method of preparing derivatives of 7-/2-(2-aminothizol-4-yl)-2-methoxyiminoacetamido/3-acetoxymethyl-3-cephem-4-carboxalic acid in form of sin-isomers
US05/886,421 US4288434A (en) 1977-03-25 1978-03-14 Cephalosporanic acid derivatives
DK129578A DK159156C (en) 1977-03-25 1978-03-22 METHOD OF ANALOGUE FOR THE PREPARATION OF (2- (2-AMINOTHIAZOL-4-YL) -2- (0-SUBSTITUTED) -OXYIMINOACETAMIDO) -7-CEPHALOSPORANIC ACID AND PHYSIOLOGY ACCEPTABLE SALTS THEREOF
ES468169A ES468169A1 (en) 1977-03-25 1978-03-22 Cephalosporanic acid derivatives
HU78RO972A HU182567B (en) 1977-03-25 1978-03-22 Prcess for preparing new oxime derivatives of 3-acetoxymethyl-7-amino-thiazolyl-acetamido-cef-3-em-4-carboxylic acid
DE2858771A DE2858771C2 (en) 1977-03-25 1978-03-22
DE19782812625 DE2812625A1 (en) 1977-03-25 1978-03-22 OXIMER DERIVATIVES OF 3-ACETOXYMETHYL-7-AMINOTHIAZOLYL-ACETAMIDO-CEPHALOSPORANIC ACID, THEIR PRODUCTION AND PHARMACEUTICAL AGENTS
PT67815A PT67815A (en) 1977-03-25 1978-03-23 PROCESS FOR THE PREPARATION OF NOVEL OXIMES DERIVED FROM CEPHALOSPORANIC 3-ACETOXYMETHYL 7-AMINOTHIAZOLYL ACETAMIDO ACID
CH1361/84A CH648555A5 (en) 1977-03-25 1978-03-23 ESTER OF A THIAZOLYLACETIC ACID.
GB11613/78A GB1605175A (en) 1977-03-25 1978-03-23 Oxime derivatives of 7-(amino-thiazolyl-acetamido)-cephalosporanic acid process for preparing them and pharmaceutical compositions containing them
CH322978A CH633292A5 (en) 1977-03-25 1978-03-23 OXIMES DERIVED FROM 3-ACETOXYMETHYL 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS.
CA299,661A CA1125280A (en) 1977-03-25 1978-03-23 Process for the preparation of novel oxime derivatives of 3-acetoxymethyl 7-amino-thiazolyl-acetamido-cephalosporanic acid
GB16825/80A GB1605176A (en) 1977-03-25 1978-03-23 Oxime derivatives of 7-amino-thiazolyl-acetic acid and processes for preparing them
AU34471/78A AU520657B2 (en) 1977-03-25 1978-03-23 Oxime Derivatives of 3- acetoxy methyl 7-amino thiazolyl acetamido cephalosporanic acid, process for preparing them and pharmaceutical compositions
NL7803166A NL192041C (en) 1977-03-25 1978-03-23 Medicinal product with antibacterial action and 7- (2- (2-aminothiazol-4-yl) -2- (etherified oxyimino) -acetamido -3-cephem-4-carboxylic acid derivatives.
JP3319378A JPS53119887A (en) 1977-03-25 1978-03-24 Novel oxime derivative of 33acetoxymethyll 77aminothiazolylacetoamide cephalospolanate process for preparing same and pharmaceutical composition
IT48604/78A IT1103478B (en) 1977-03-25 1978-03-24 OXIME DERIVED FROM THE ACID 3-ACETOS SIMETIL 7-AMINO-THIAZOLYL-ACETAMIDE CEPHALOSPORANIC PROCEDURE FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AS AN ACTIVE INGREDIENT
LU79312A LU79312A1 (en) 1977-03-25 1978-03-24 PROCESS FOR THE PREPARATION OF NEW OXIMES DERIVED FROM 3-ACETOXYMETHYL-7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC
PH20927A PH15764A (en) 1977-03-25 1978-03-27 Cephalosporanic acid derivatives
AT218378A AT360153B (en) 1977-03-25 1978-03-28 METHOD FOR PRODUCING NEW CONNECTIONS
IE604/78A IE47361B1 (en) 1977-03-25 1978-03-29 New oxime derivatives of (amino-thiazolyl-acetamido)-cephalosporanic acid,processes for preparing them and pharmaceutical compositions containing them
IE1518/83A IE47362B1 (en) 1977-03-25 1978-03-29 New oxime derivatives of 7-amino-thiazolyl-acetic acid,and processes for preparing them
GB307781A GB1605177A (en) 1977-12-05 1978-05-31 Oxime derivatives of 5'-amino-thiazolyl-acetic acid and processes for preparing them
ES477592A ES477592A1 (en) 1977-03-25 1979-02-09 Cephalosporanic acid derivatives
AT607579A AT361122B (en) 1977-12-05 1979-09-14 METHOD FOR PRODUCING NEW CONNECTIONS
AT331380A AT376215B (en) 1977-03-25 1980-06-24 METHOD FOR PRODUCING NEW SUBSTITUTED 2- (2-AMINO-4-THIAZOLYL) -2-HYDROXYIMINO ACETIC ACID N
US06/260,311 US4386210A (en) 1977-03-25 1981-05-04 2-(2-Amino-4-thiazolyl)-2-methoxyimino-acetic acid derivatives
CA379,842A CA1132575A (en) 1977-03-25 1981-06-16 2-(2-amino-4-thiazolyl)2-hydroxyimino acetic acid derivatives and preparation process of same
CH386882A CH639652A5 (en) 1977-03-25 1982-06-18 THIAZOLYL ACETIC ACIDS, THEIR ESTERS AND THEIR PREPARATION METHODS.
US06/469,710 US4487937A (en) 1977-03-25 1983-02-25 2-(2-Substitutedamino-4-thiazolyl)-2-(1-methoxy-isopropoxyimino)-acetic acids
SE8304239A SE453192B (en) 1977-03-25 1983-08-02 NEW INTERMEDIATES USEFUL FOR THE PREPARATION OF OXIME DERIVATIVES OF 3-ACETOXIMETHYL-7-AMINOTIAZOLYL-ACETAMIDO-CEPHALOSPORINIC ACID AND PROCEDURE FOR PREPARING THE INTERMEDIATES
CH644383A CH646159A5 (en) 1977-03-25 1983-12-02 THIAZOLYL ACETIC ACIDS AND THEIR PREPARATION.
US06/574,876 US4483981A (en) 1977-03-25 1984-01-30 Cephalosporanic acid derivatives
JP63152471A JPS6425768A (en) 1977-03-25 1988-06-22 2-(2-amino-4-thiazolyl)-2-methoxyiminoacetic acid derivative and manufacture

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7736512A FR2421906A2 (en) 1977-12-05 1977-12-05 NEW OXIMES DERIVED FROM 3-ACETOXY METHYL 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS

Publications (2)

Publication Number Publication Date
FR2421906A2 true FR2421906A2 (en) 1979-11-02
FR2421906B2 FR2421906B2 (en) 1984-05-25

Family

ID=9198438

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7736512A Granted FR2421906A2 (en) 1977-03-25 1977-12-05 NEW OXIMES DERIVED FROM 3-ACETOXY METHYL 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS

Country Status (3)

Country Link
FR (1) FR2421906A2 (en)
GB (1) GB1605177A (en)
SU (1) SU882412A3 (en)

Also Published As

Publication number Publication date
FR2421906B2 (en) 1984-05-25
GB1605177A (en) 1982-11-17
SU882412A3 (en) 1981-11-15

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