FR2402666A1 - 5-iminodaunomycine et medicament la contenant - Google Patents

5-iminodaunomycine et medicament la contenant

Info

Publication number
FR2402666A1
FR2402666A1 FR7825739A FR7825739A FR2402666A1 FR 2402666 A1 FR2402666 A1 FR 2402666A1 FR 7825739 A FR7825739 A FR 7825739A FR 7825739 A FR7825739 A FR 7825739A FR 2402666 A1 FR2402666 A1 FR 2402666A1
Authority
FR
France
Prior art keywords
iminodaunomycin
product containing
medicinal product
relates
cardiotoxic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7825739A
Other languages
English (en)
Other versions
FR2402666B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SRI International Inc
Original Assignee
SRI International Inc
Stanford Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SRI International Inc, Stanford Research Institute filed Critical SRI International Inc
Publication of FR2402666A1 publication Critical patent/FR2402666A1/fr
Application granted granted Critical
Publication of FR2402666B1 publication Critical patent/FR2402666B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

L'invention a trait au domaine de la chimie médicale. Elle concerne, à titre de composé nouveau, la 5-iminodaunomycine et ses sels acceptables du point de vue pharmaceutique. Les composés de l'invention sont doués d'une bonne activité antitumorale, tout en étant peu cardiotoxiques.
FR7825739A 1977-09-08 1978-09-07 5-iminodaunomycine et medicament la contenant Granted FR2402666A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/831,438 US4109076A (en) 1977-09-08 1977-09-08 5-iminodaunomycin

Publications (2)

Publication Number Publication Date
FR2402666A1 true FR2402666A1 (fr) 1979-04-06
FR2402666B1 FR2402666B1 (fr) 1980-10-31

Family

ID=25259058

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7825739A Granted FR2402666A1 (fr) 1977-09-08 1978-09-07 5-iminodaunomycine et medicament la contenant

Country Status (7)

Country Link
US (1) US4109076A (fr)
JP (1) JPS5492950A (fr)
CA (1) CA1110619A (fr)
DE (1) DE2838895C2 (fr)
FR (1) FR2402666A1 (fr)
GB (1) GB2005256B (fr)
IT (1) IT1106299B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4353894A (en) * 1980-10-27 1982-10-12 Sri International 5-Iminodoxorubicin
US4826964A (en) * 1982-07-20 1989-05-02 Sri International Bridged oxygen analogs of daunorubcin and doxorubicin
US4464529A (en) * 1982-07-20 1984-08-07 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin
ZA834867B (en) * 1982-07-20 1984-03-28 Stanford Res Inst Int Derivatives of morpholinyl daunorubicin and morpholinyl doxorubicin and analogues thereof
US5977082A (en) * 1985-08-02 1999-11-02 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5124317A (en) 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
GB8617742D0 (en) * 1986-07-21 1986-08-28 Erba Farmitalia 6-amino anthracyclines
NZ224252A (en) * 1987-04-21 1991-09-25 Erba Carlo Spa An anthracycline glycoside and its preparation
US5196522A (en) * 1990-11-01 1993-03-23 Board Of Regents, The University Of Texas System Anthracycline analogues bearing latent alkylating substituents
US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
US5942605A (en) * 1998-03-03 1999-08-24 Gem Pharmaceuticals, Inc. 5-imino-13-deoxy anthracycline derivatives, their uses, and processes for preparing them

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3803124A (en) * 1968-04-12 1974-04-09 Farmaceutici It Soc Process for the preparation of adriamycin and adriamycinone and adriamycin derivatives

Also Published As

Publication number Publication date
IT1106299B (it) 1985-11-11
JPS6259712B2 (fr) 1987-12-12
DE2838895A1 (de) 1979-03-22
JPS5492950A (en) 1979-07-23
IT7850986A0 (it) 1978-09-06
GB2005256A (en) 1979-04-19
DE2838895C2 (de) 1986-04-17
CA1110619A (fr) 1981-10-13
US4109076A (en) 1978-08-22
FR2402666B1 (fr) 1980-10-31
GB2005256B (en) 1982-02-03

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Legal Events

Date Code Title Description
ST Notification of lapse