FR2399479A1 - Procede de sechage par congelation pour la preparation de vaccin contre le meningocoque - Google Patents

Procede de sechage par congelation pour la preparation de vaccin contre le meningocoque

Info

Publication number
FR2399479A1
FR2399479A1 FR7822977A FR7822977A FR2399479A1 FR 2399479 A1 FR2399479 A1 FR 2399479A1 FR 7822977 A FR7822977 A FR 7822977A FR 7822977 A FR7822977 A FR 7822977A FR 2399479 A1 FR2399479 A1 FR 2399479A1
Authority
FR
France
Prior art keywords
drying process
preparing
meningococcal vaccine
freeze drying
degrees
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7822977A
Other languages
English (en)
Other versions
FR2399479B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of FR2399479A1 publication Critical patent/FR2399479A1/fr
Application granted granted Critical
Publication of FR2399479B1 publication Critical patent/FR2399479B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

L'invention concerne un procédé de séchage par congélation pour la préparation de vaccin contre le méningocoque. L'antigène polysaccharide du groupe A purifié isolé à partir de N. meningitidis pour vaccination contre ce type de méningite bactérienne est préparé à partir d'une solution aqueuse isotonique de chlorure de sodium séchée par congélation à des températures comprises entre -20 degrés C et -30 degrés C. Cette lyophilisation à basse température sèche la solution isotonique de polysaccharide au chlorure de sodium sans perte de masse moléculaire, c'est-à-dire d'activité.
FR7822977A 1977-08-05 1978-08-03 Procede de sechage par congelation pour la preparation de vaccin contre le meningocoque Granted FR2399479A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/822,309 US4134214A (en) 1977-08-05 1977-08-05 Freeze-drying process for the preparation of meningococcus vaccine without degradation of potency

Publications (2)

Publication Number Publication Date
FR2399479A1 true FR2399479A1 (fr) 1979-03-02
FR2399479B1 FR2399479B1 (fr) 1981-07-24

Family

ID=25235699

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7822977A Granted FR2399479A1 (fr) 1977-08-05 1978-08-03 Procede de sechage par congelation pour la preparation de vaccin contre le meningocoque

Country Status (14)

Country Link
US (1) US4134214A (fr)
JP (1) JPS5435213A (fr)
BE (1) BE869498A (fr)
CA (1) CA1112168A (fr)
CH (1) CH638984A5 (fr)
DE (1) DE2834144A1 (fr)
DK (1) DK319778A (fr)
FR (1) FR2399479A1 (fr)
GB (1) GB2001851B (fr)
IE (1) IE47226B1 (fr)
IT (1) IT1107555B (fr)
LU (1) LU80070A1 (fr)
NL (1) NL7807635A (fr)
SE (1) SE7807976L (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5750752A (en) * 1980-09-10 1982-03-25 Nippon Electric Glass Co Ltd Panel glass for color cathode ray tube
BE889979A (fr) * 1981-08-14 1982-02-15 Smith Kline Rit Procede de preparation de polysaccharides bacteriens capsulaires antigeniques purifies, produits obtenus et leur utilisation
CA1202903A (fr) * 1982-04-29 1986-04-08 Edgar E. Ribi Composition stable, et sa preparation
US4681761A (en) * 1985-10-24 1987-07-21 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University Major iron-regulated protein of Neisseria gonorrhoeae and its use as vaccine
US5439808A (en) * 1993-07-23 1995-08-08 North American Vaccine, Inc. Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis
US5747287A (en) * 1995-04-28 1998-05-05 North American Vaccine, Inc. Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis
GB0115176D0 (en) 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
US20030138434A1 (en) * 2001-08-13 2003-07-24 Campbell Robert L. Agents for enhancing the immune response
PL1942932T3 (pl) 2005-08-08 2013-11-29 Univ Oregon Health & Science Inaktywacja patogenów nadtlenkiem wodoru do wytwarzania szczepionek
EP1870649A1 (fr) * 2006-06-20 2007-12-26 Octapharma AG Lyophilisation visant à obtenir une humidité résiduelle déterminée par énergie de désorption aux niveaux limités
US9125951B2 (en) 2009-06-22 2015-09-08 Wyeth Llc Compositions and methods for preparing Staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions
SI2445522T1 (sl) 2009-06-22 2017-10-30 Wyeth Llc Imunogeni sestavki antigenov Staphylococcusa aureusa

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1055841A (fr) * 1950-04-04 1954-02-22 Merck & Co Inc Procédé de stérilisation de substances, telles que substances thermolabiles
US3449885A (en) * 1966-03-31 1969-06-17 Ben Venue Lab Inc Method of packaging viral antisera and other research diagnostic reagents
US3594913A (en) * 1968-10-04 1971-07-27 George Tooby Method for dehydrating materials
US3607858A (en) * 1970-03-31 1971-09-21 American Cyanamid Co Process for preparing lyophilized human blood proteins such as gamma globulin in the presence of a nonionic surfactant

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CA1977 *
NV2030/77 *

Also Published As

Publication number Publication date
DK319778A (da) 1979-02-06
BE869498A (fr) 1979-02-05
IT1107555B (it) 1985-11-25
US4134214A (en) 1979-01-16
SE7807976L (sv) 1979-02-06
IE781594L (en) 1979-02-05
FR2399479B1 (fr) 1981-07-24
JPS5435213A (en) 1979-03-15
CA1112168A (fr) 1981-11-10
DE2834144C2 (fr) 1987-08-06
NL7807635A (nl) 1979-02-07
IT7850486A0 (it) 1978-07-26
LU80070A1 (fr) 1979-05-15
GB2001851A (en) 1979-02-14
CH638984A5 (de) 1983-10-31
DE2834144A1 (de) 1979-02-22
GB2001851B (en) 1982-03-24
IE47226B1 (en) 1984-01-25

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