FR2392671A1 - Application pharmacologique des acides d2-3-1,4-morpholine-2-carboxyliques substitues - Google Patents
Application pharmacologique des acides d2-3-1,4-morpholine-2-carboxyliques substituesInfo
- Publication number
- FR2392671A1 FR2392671A1 FR7825512A FR7825512A FR2392671A1 FR 2392671 A1 FR2392671 A1 FR 2392671A1 FR 7825512 A FR7825512 A FR 7825512A FR 7825512 A FR7825512 A FR 7825512A FR 2392671 A1 FR2392671 A1 FR 2392671A1
- Authority
- FR
- France
- Prior art keywords
- morpholine
- substituted
- carboxylic acids
- pharmacological application
- pharmacological
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 230000000144 pharmacologic effect Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La présente invention a pour objet l'application pharmacologique des composés de formule II :
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/567,323 US4011216A (en) | 1975-04-11 | 1975-04-11 | Δ2,3-0-2-Isocephem-4-carboxylic acid and derivatives thereof as antibacterial agents |
Publications (1)
Publication Number | Publication Date |
---|---|
FR2392671A1 true FR2392671A1 (fr) | 1978-12-29 |
Family
ID=24266689
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7609916A Granted FR2313065A1 (fr) | 1975-04-11 | 1976-04-06 | Procede de synthese stereo selective totale de certains acides d2-3-1,4-morpholine 2-carboxyliques substitues |
FR7825512A Withdrawn FR2392671A1 (fr) | 1975-04-11 | 1978-09-05 | Application pharmacologique des acides d2-3-1,4-morpholine-2-carboxyliques substitues |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7609916A Granted FR2313065A1 (fr) | 1975-04-11 | 1976-04-06 | Procede de synthese stereo selective totale de certains acides d2-3-1,4-morpholine 2-carboxyliques substitues |
Country Status (6)
Country | Link |
---|---|
US (6) | US4011216A (fr) |
JP (2) | JPS51122091A (fr) |
BE (1) | BE840543A (fr) |
CA (1) | CA1092110A (fr) |
DE (1) | DE2615693A1 (fr) |
FR (2) | FR2313065A1 (fr) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4226866A (en) * | 1972-11-06 | 1980-10-07 | Merck & Co., Inc. | Novel antibiotic analogues of cephalosporins |
DK154939C (da) * | 1974-12-19 | 1989-06-12 | Takeda Chemical Industries Ltd | Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf |
US4012383A (en) * | 1975-01-02 | 1977-03-15 | Bristol-Myers Company | Δ2,3 -1,4-morpholine-2-carboxylic acids and derivatives thereof useful in preparation of antibacteria agents |
US4171439A (en) * | 1975-04-11 | 1979-10-16 | Bristol-Myers Company | Antibacterial analogs of isocephalosporins |
US4166905A (en) * | 1975-04-11 | 1979-09-04 | Bristol-Myers Company | O-2-Isocephem-4-carboxylic acid derivatives as antibacterial agents |
US4166906A (en) * | 1975-04-11 | 1979-09-04 | Bristol-Myers Company | 0-2-Isocephem-4-carboxylic acid derivatives as antibacterial agents |
US4108992A (en) * | 1975-05-10 | 1978-08-22 | Beecham Group Limited | Cephalosporin analogues and compositions |
US4171438A (en) * | 1975-07-23 | 1979-10-16 | Bristol-Myers Company | 0-2-Isocephem-4-carboxylic acid derivatives as antibacterial agents |
US4013648A (en) * | 1975-07-23 | 1977-03-22 | Bristol-Myers Company | Δ2,3 -0-2-Isocephem-4-carboxylic acid and derivatives as antibacterial agents |
US4200572A (en) * | 1975-09-03 | 1980-04-29 | Smithkline Corporation | Substituted azetidinones |
CA1085392A (fr) * | 1976-03-25 | 1980-09-09 | Masayuki Narisada | Arylmalonamido-1-oxadethiacephalosporines |
US4089956A (en) * | 1976-09-08 | 1978-05-16 | Smithkline Corporation | 7-Acylamino-8-oxo-3-oxa-1-azabicyclo[4.2.0]octane-2-carboxylic acid derivatives and bactericidal compositions and use thereof |
US4162250A (en) * | 1976-09-08 | 1979-07-24 | Smithkline Corporation | 3-Aminoazetidinone derivatives |
US4187375A (en) * | 1976-09-08 | 1980-02-05 | Smithkline Corporation | Process for preparing oxazine ring compounds |
US4210661A (en) * | 1977-01-27 | 1980-07-01 | Beecham Group Limited | Synthetic β-lactam compounds, a process for their preparation and compositions containing them |
GB1584762A (en) * | 1977-04-01 | 1981-02-18 | Beecham Group Ltd | Azabicycloheptenes |
US4257947A (en) * | 1977-08-03 | 1981-03-24 | Smithkline Corporation | 3-Amino-2-hydroxy, halo or mercaptomethyl-4-oxoazetidines |
EP0002564B1 (fr) * | 1977-11-12 | 1984-06-20 | Beecham Group Plc | Dérivés de l'acide 7-oxo-1-azabicyclo-(3.2.0)-hept-2-ène-2-carboxylique, leur préparation, compositions pharmaceutiques les contenant et produits intermédiaires |
US4218459A (en) * | 1977-12-28 | 1980-08-19 | Merck & Co., Inc. | 6-Amido-1-carba-2-penem-3-carboxylic acid |
JPS5936914B2 (ja) * | 1978-06-24 | 1984-09-06 | 協和醗酵工業株式会社 | セフアロスポリン類縁体 |
US4140688A (en) * | 1978-04-03 | 1979-02-20 | Smithkline Corporation | Tricyclic (azeto-isoquinoline) β-lactams |
JPH02111750A (ja) * | 1978-09-12 | 1990-04-24 | Fujisawa Pharmaceut Co Ltd | 酪酸誘導体 |
JPS5690088A (en) * | 1979-11-02 | 1981-07-21 | Meiji Seika Kaisha Ltd | Novel cephalosporin analog compound |
US4337197A (en) * | 1980-10-31 | 1982-06-29 | E. R. Squibb & Sons, Inc. | O-sulfated β-lactam hydroxamic acids and intermediates |
FR2505840A1 (fr) * | 1981-05-13 | 1982-11-19 | Roussel Uclaf | Nouveaux produits derives de l'acide 2-amino thiazolyl 2-oxyimino acetamido bicyclo-octene carboxylique, leur procede de preparation et leur application comme medicaments |
FR2552089B2 (fr) * | 1981-05-13 | 1985-10-25 | Roussel Uclaf | Nouveaux produits derives de l'acide 2-amino thiazolyl 2-oxyimino acetamido bicyclo-octene carboxylique, leur procede de preparation et leur application comme medicaments |
JPS5936684A (ja) * | 1982-08-24 | 1984-02-28 | Shionogi & Co Ltd | 1−オキサセフアム化合物の製造方法 |
US4903888A (en) | 1988-05-05 | 1990-02-27 | Westinghouse Electric Corp. | Turbine system having more failure resistant rotors and repair welding of low alloy ferrous turbine components by controlled weld build-up |
JP3775820B2 (ja) * | 1995-03-10 | 2006-05-17 | 大塚化学ホールディングス株式会社 | ハロゲン化β−ラクタム化合物の製造法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1914366A1 (de) * | 1969-03-21 | 1970-10-01 | Bayer Ag | Arzneimittel auf Basis neuer,heterocyclischer Verbindungen |
CH541577A (de) * | 1970-11-03 | 1973-09-15 | Ciba Geigy Ag | Verfahren zur Herstellung thiaheterocyclischer Verbindungen |
DE2219601A1 (de) | 1971-04-27 | 1972-11-16 | Astra Läkemedel AB, Södertälje (Schweden) | beta-Lactame und Verfahren zu deren Herstellung |
NL178005C (nl) * | 1972-11-06 | 1986-01-02 | Merck & Co Inc | Werkwijze voor het bereiden van een farmaceutisch preparaat met antibacteriele werking, alsmede werkwijze ter bereiding van een cefalosporine-antibioticum. |
US4012383A (en) * | 1975-01-02 | 1977-03-15 | Bristol-Myers Company | Δ2,3 -1,4-morpholine-2-carboxylic acids and derivatives thereof useful in preparation of antibacteria agents |
US4013648A (en) * | 1975-07-23 | 1977-03-22 | Bristol-Myers Company | Δ2,3 -0-2-Isocephem-4-carboxylic acid and derivatives as antibacterial agents |
-
1975
- 1975-04-11 US US05/567,323 patent/US4011216A/en not_active Expired - Lifetime
-
1976
- 1976-04-06 FR FR7609916A patent/FR2313065A1/fr active Granted
- 1976-04-08 BE BE165979A patent/BE840543A/fr unknown
- 1976-04-08 CA CA249,865A patent/CA1092110A/fr not_active Expired
- 1976-04-09 DE DE19762615693 patent/DE2615693A1/de not_active Withdrawn
- 1976-04-12 JP JP51040422A patent/JPS51122091A/ja active Granted
- 1976-08-19 US US05/715,943 patent/US4066832A/en not_active Expired - Lifetime
- 1976-08-19 US US05/715,956 patent/US4068080A/en not_active Expired - Lifetime
- 1976-08-19 US US05/715,819 patent/US4068078A/en not_active Expired - Lifetime
- 1976-08-19 US US05/715,820 patent/US4068075A/en not_active Expired - Lifetime
-
1977
- 1977-01-17 US US05/759,710 patent/US4112230A/en not_active Expired - Lifetime
-
1978
- 1978-09-05 FR FR7825512A patent/FR2392671A1/fr not_active Withdrawn
-
1985
- 1985-02-01 JP JP60016684A patent/JPS60214788A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
BE840543A (fr) | 1976-10-08 |
JPS51122091A (en) | 1976-10-25 |
FR2313065B1 (fr) | 1981-12-31 |
US4011216A (en) | 1977-03-08 |
DE2615693A1 (de) | 1976-10-28 |
US4112230A (en) | 1978-09-05 |
US4066832A (en) | 1978-01-03 |
CA1092110A (fr) | 1980-12-23 |
JPS60214788A (ja) | 1985-10-28 |
US4068075A (en) | 1978-01-10 |
US4068078A (en) | 1978-01-10 |
JPS6133034B2 (fr) | 1986-07-31 |
US4068080A (en) | 1978-01-10 |
JPS6132317B2 (fr) | 1986-07-25 |
FR2313065A1 (fr) | 1976-12-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |