FR2383929A1 - 1-hydroxy 2, 3, 4, 5-tetrahydro-1h-3-benzazepines substituees - Google Patents

1-hydroxy 2, 3, 4, 5-tetrahydro-1h-3-benzazepines substituees

Info

Publication number
FR2383929A1
FR2383929A1 FR7820342A FR7820342A FR2383929A1 FR 2383929 A1 FR2383929 A1 FR 2383929A1 FR 7820342 A FR7820342 A FR 7820342A FR 7820342 A FR7820342 A FR 7820342A FR 2383929 A1 FR2383929 A1 FR 2383929A1
Authority
FR
France
Prior art keywords
benzazepines
tetrahydro
hydroxy
substituted
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7820342A
Other languages
English (en)
Other versions
FR2383929B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline LLC
Original Assignee
SmithKline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Corp filed Critical SmithKline Corp
Publication of FR2383929A1 publication Critical patent/FR2383929A1/fr
Application granted granted Critical
Publication of FR2383929B1 publication Critical patent/FR2383929B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Abstract

L'invention a pour objet des composés de formule :
FR7820342A 1977-02-02 1978-07-07 1-hydroxy 2, 3, 4, 5-tetrahydro-1h-3-benzazepines substituees Granted FR2383929A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/764,672 US4111957A (en) 1977-02-02 1977-02-02 Substituted 1-thienyl and furyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds

Publications (2)

Publication Number Publication Date
FR2383929A1 true FR2383929A1 (fr) 1978-10-13
FR2383929B1 FR2383929B1 (fr) 1981-07-31

Family

ID=25071413

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7802275A Granted FR2379534A1 (fr) 1977-02-02 1978-01-27 1-thienyl- et furyl-2,3,4,5-tetrahydro-1h-3-benzazepine substituees
FR7820342A Granted FR2383929A1 (fr) 1977-02-02 1978-07-07 1-hydroxy 2, 3, 4, 5-tetrahydro-1h-3-benzazepines substituees

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR7802275A Granted FR2379534A1 (fr) 1977-02-02 1978-01-27 1-thienyl- et furyl-2,3,4,5-tetrahydro-1h-3-benzazepine substituees

Country Status (6)

Country Link
US (1) US4111957A (fr)
JP (2) JPS5395989A (fr)
BE (1) BE868868A (fr)
DE (1) DE2804285A1 (fr)
FR (2) FR2379534A1 (fr)
GB (1) GB1599705A (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4352754A (en) * 1976-11-17 1982-10-05 Smithkline Corporation 3-Thienylmethyl-6-halo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
JPS5481290A (en) * 1977-11-17 1979-06-28 Smithkline Corp Benzazepin compound
ZA792785B (en) * 1978-07-07 1980-08-27 Smithkline Corp Mercapto substituted-2,3,4,5-tetrahydro-1h-3-benzazepines
US4282146A (en) * 1978-11-20 1981-08-04 Pennwalt Corporation Preparation of 1,2,4,5-tetrahydro-7-alkoxy-(and 7,8-dialkoxy)-3H,3-benzazepines and 3-substituted derivatives thereof from the corresponding phenethylamines
US4255445A (en) * 1980-03-07 1981-03-10 Smithkline Corporation 8-Hydroxy-6,7-(2-methyl-2,3-dihydrofuro)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
DK180485D0 (da) * 1985-04-22 1985-04-23 Novo Industri As Nitrogenholdige forbindelser
US4769368A (en) * 1986-02-10 1988-09-06 Smithkline Beckman Corporation 2,3,4,8,9,9A-Hexahydro-4-aryl-1H-indeno(1,7-CD)azepines
DK67489D0 (da) * 1989-02-14 1989-02-14 Novo Industri As Nye benzazepinderivater
JPH03153111A (ja) * 1989-11-09 1991-07-01 Murata Mfg Co Ltd 弾性表面波発振器
GB9903671D0 (en) * 1999-02-17 1999-04-14 Cenes Ltd Dopamine D-1 receptor agonist compounds
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
EA016558B1 (ru) * 2003-06-17 2012-05-30 Арена Фармасьютикалз, Инк. Производные бензазепина, используемые для лечения заболеваний, ассоциированных с 5-ht-рецептором
HUE028976T2 (en) * 2003-06-17 2017-02-28 Arena Pharm Inc 8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
US20080009478A1 (en) * 2003-10-22 2008-01-10 Arena Pharmaceuticals, Inc. Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2c Receptor Associated Diseases
WO2005042490A1 (fr) * 2003-10-22 2005-05-12 Arena Pharmaceuticals, Inc. Derives de benzazepine et methodes de prophylaxie ou de traitement de maladies associees au recepteur 5-ht2c
JP5270167B2 (ja) 2004-12-21 2013-08-21 アリーナ ファーマシューティカルズ， インコーポレイテッド （ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンザゼピン塩酸塩の結晶形
CN102631349A (zh) 2004-12-23 2012-08-15 艾尼纳制药公司 5HT2c受体调节剂组合物和使用方法
JP5199997B2 (ja) 2006-04-03 2013-05-15 アリーナ ファーマシューティカルズ， インコーポレイテッド ８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンズアゼピンおよびこれに関連する中間体を調製するためのプロセス
CN101547892B (zh) * 2006-12-05 2014-08-20 艾尼纳制药公司 制备(r)-8-氯-1-甲基-2,3,4,5-四氢-1h-3-苯并氮杂卓的方法和其中间体
JP4933325B2 (ja) * 2007-03-29 2012-05-16 原田工業株式会社 接続端子構造
JP5491421B2 (ja) * 2008-03-04 2014-05-14 アリーナ ファーマシューティカルズ， インコーポレイテッド ５−ｈｔ２ｃアゴニストである（ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピンに関連する中間体の調製のためのプロセス
WO2010148207A2 (fr) 2009-06-18 2010-12-23 Arena Pharmaceuticals, Inc. Procédés pour la préparation d'agonistes du récepteur 5-ht2c
WO2011153206A1 (fr) 2010-06-02 2011-12-08 Arena Pharmaceuticals, Inc. Procédés pour la préparation d'agonistes du récepteur 5-ht2c
SG10201506870PA (en) 2010-09-01 2015-10-29 Arena Pharm Inc Salts of lorcaserin with optically active acids
SG188362A1 (en) 2010-09-01 2013-04-30 Arena Pharm Inc Modified-release dosage forms of 5-ht2c agonists useful for weight management
US8999970B2 (en) 2010-09-01 2015-04-07 Arena Pharmaceuticals, Inc. Administration of an anti-obesity compound to individuals with renal impairment
EP2611433A2 (fr) 2010-09-01 2013-07-10 Arena Pharmaceuticals, Inc. Sels non hygroscopiques d'agonistes de 5-ht2c
KR20150070249A (ko) 2012-10-09 2015-06-24 아레나 파마슈티칼스, 인크. 체중 관리 방법

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3393192A (en) * 1965-04-26 1968-07-16 Schering Corp Novel benzazepines
US3609138A (en) * 1967-12-22 1971-09-28 Ciba Geigy Corp 1-aryl-3-benzazepines
US3663532A (en) * 1970-03-04 1972-05-16 American Home Prod Benzodiazocines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NV875/66 *

Also Published As

Publication number Publication date
JPS62161764A (ja) 1987-07-17
DE2804285A1 (de) 1978-08-03
FR2383929B1 (fr) 1981-07-31
FR2379534B1 (fr) 1981-11-27
FR2379534A1 (fr) 1978-09-01
JPS6341912B2 (fr) 1988-08-19
JPS5395989A (en) 1978-08-22
DE2804285C2 (fr) 1988-01-07
BE868868A (fr) 1979-01-10
GB1599705A (en) 1981-10-07
US4111957A (en) 1978-09-05

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