FR2389598A1 - - Google Patents
Info
- Publication number
- FR2389598A1 FR2389598A1 FR7713890A FR7713890A FR2389598A1 FR 2389598 A1 FR2389598 A1 FR 2389598A1 FR 7713890 A FR7713890 A FR 7713890A FR 7713890 A FR7713890 A FR 7713890A FR 2389598 A1 FR2389598 A1 FR 2389598A1
- Authority
- FR
- France
- Prior art keywords
- glucagon
- column
- less
- solution
- gel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000051325 Glucagon Human genes 0.000 abstract 6
- 108060003199 Glucagon Proteins 0.000 abstract 6
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 abstract 6
- 229960004666 glucagon Drugs 0.000 abstract 6
- 238000000034 method Methods 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- 206010016807 Fluid retention Diseases 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 238000010586 diagram Methods 0.000 abstract 1
- 239000003480 eluent Substances 0.000 abstract 1
- 238000010828 elution Methods 0.000 abstract 1
- 239000008267 milk Substances 0.000 abstract 1
- 210000004080 milk Anatomy 0.000 abstract 1
- 235000013336 milk Nutrition 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 230000008961 swelling Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/641,419 US4033941A (en) | 1975-12-17 | 1975-12-17 | Process for purifying glucagon |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2389598A1 true FR2389598A1 (enExample) | 1978-12-01 |
| FR2389598B1 FR2389598B1 (enExample) | 1981-06-19 |
Family
ID=24572291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7713890A Expired FR2389598B1 (enExample) | 1975-12-17 | 1977-05-06 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4033941A (enExample) |
| CA (1) | CA1089448A (enExample) |
| DE (1) | DE2721027A1 (enExample) |
| FR (1) | FR2389598B1 (enExample) |
| GB (1) | GB1576344A (enExample) |
| NL (1) | NL7703758A (enExample) |
| SE (1) | SE443512B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4617376A (en) * | 1985-07-01 | 1986-10-14 | Eli Lilly And Company | Process for recovering glucagon from pancreas glands |
| CA1284000C (en) * | 1985-07-01 | 1991-05-07 | David Gregory Maskalick | Process for recovering glucagon from pancreas glands |
| WO2008015099A2 (en) | 2006-07-31 | 2008-02-07 | Novo Nordisk A/S | Pegylated, extended insulins |
| BRPI0717098B8 (pt) * | 2006-09-22 | 2021-05-25 | Novo Nordisk As | análogos de insulina humana resistentes à protease, composição farmacêutica e processo para sua preparação |
| WO2008132224A2 (en) * | 2007-04-30 | 2008-11-06 | Novo Nordisk A/S | Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein |
| EP2164459A1 (en) * | 2007-06-01 | 2010-03-24 | Novo Nordisk A/S | Stable non-aqueous pharmaceutical compositions |
| EP2254905B1 (en) * | 2008-03-14 | 2016-12-14 | Novo Nordisk A/S | Protease-stabilized insulin analogues |
| PT2254906T (pt) | 2008-03-18 | 2017-01-03 | Novo Nordisk As | Análogos de insulina acilados, estabilizados contra proteases |
| CN104364260B (zh) | 2012-04-11 | 2017-02-22 | 诺和诺德股份有限公司 | 胰岛素制剂 |
| MX366636B (es) | 2013-10-07 | 2019-07-17 | Novo Nordisk As | Nuevo derivado de un análogo de insulina. |
| TWI700091B (zh) | 2016-12-16 | 2020-08-01 | 丹麥商諾佛 儂迪克股份有限公司 | 含胰島素醫藥組成物 |
| EP3517543B1 (en) | 2018-01-30 | 2020-11-04 | Bachem AG | Manufacture of glucagon peptides |
| CN113024658B (zh) * | 2019-12-25 | 2022-10-21 | 翰宇药业（武汉）有限公司 | 一种纯化利拉鲁肽的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3715345A (en) * | 1970-08-03 | 1973-02-06 | Lilly Co Eli | Glucagon separation process |
| DE2258080C3 (de) * | 1972-11-27 | 1981-12-17 | Eli Lilly And Co., Indianapolis, Ind. | Verfahren zur Gewinnung von Hexatriacontapeptiden |
| US3878186A (en) * | 1973-05-09 | 1975-04-15 | Lilly Co Eli | Process for purifying insulin |
| US3875138A (en) * | 1973-09-27 | 1975-04-01 | Lilly Co Eli | Process for recovering glucagon |
-
1975
- 1975-12-17 US US05/641,419 patent/US4033941A/en not_active Expired - Lifetime
-
1977
- 1977-04-04 CA CA275,504A patent/CA1089448A/en not_active Expired
- 1977-04-05 NL NL7703758A patent/NL7703758A/xx not_active Application Discontinuation
- 1977-04-14 GB GB15474/77A patent/GB1576344A/en not_active Expired
- 1977-05-03 SE SE7705162A patent/SE443512B/xx not_active IP Right Cessation
- 1977-05-06 FR FR7713890A patent/FR2389598B1/fr not_active Expired
- 1977-05-10 DE DE19772721027 patent/DE2721027A1/de not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US4033941A (en) | 1977-07-05 |
| GB1576344A (en) | 1980-10-08 |
| DE2721027A1 (de) | 1978-11-16 |
| SE7705162L (sv) | 1978-11-04 |
| FR2389598B1 (enExample) | 1981-06-19 |
| CA1089448A (en) | 1980-11-11 |
| NL7703758A (nl) | 1978-10-09 |
| SE443512B (sv) | 1986-03-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |