FR2387217A2 - Derives substitues de 9-desoxy-9-methylene prostaglandines et compositions pharmaceutiques comprenant de tels derives - Google Patents
Derives substitues de 9-desoxy-9-methylene prostaglandines et compositions pharmaceutiques comprenant de tels derivesInfo
- Publication number
- FR2387217A2 FR2387217A2 FR7810582A FR7810582A FR2387217A2 FR 2387217 A2 FR2387217 A2 FR 2387217A2 FR 7810582 A FR7810582 A FR 7810582A FR 7810582 A FR7810582 A FR 7810582A FR 2387217 A2 FR2387217 A2 FR 2387217A2
- Authority
- FR
- France
- Prior art keywords
- methylene
- derivatives
- compounds
- deoxy
- type
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229940094443 oxytocics prostaglandins Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 150000002148 esters Chemical class 0.000 abstract 2
- 150000003180 prostaglandins Chemical class 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- -1 p-substituted phenyl esters Chemical class 0.000 abstract 1
- 239000002831 pharmacologic agent Substances 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
La présente invention concerne les analogues de prostaglandines comprenant un groupement méthylène en position 9 et leur préparation. De façon particulière, elle concerne de nouveaux dérivés amido-cycloamido, carbonylamido et sulfonylamido ainsi que ester p-phényle substitué de composés du type 9-déoxy-9-méthylène-PGF. Ces nouveaux composés ont une activité prolongée comme agents pharmacologiques comparativement aux composés précédemment connus du type 9-déoxy-9-méthylène-PGF. En outre, ces nouveaux esters phényliques p-substitués donnent des formules pharmaceutiques plus stables que les esters connus du type 9-déoxy-9-méthylène-PGF. Par ailleurs, l'invention vise une nouvelle série de composés du type 16-phényl-9-déoxy-9-méthylène-PGF sous forme d'acide libre, d'ester, dalcool en C1 et d'amine en C1 . Application de ces composés comme médicaments exerçant une action caractéristique du type prostaglandine.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/786,250 US4098805A (en) | 1977-04-11 | 1977-04-11 | 9-deoxy-9-methylene-pgf-type amides |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2387217A2 true FR2387217A2 (fr) | 1978-11-10 |
FR2387217B2 FR2387217B2 (fr) | 1981-04-30 |
Family
ID=25138056
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7810582A Granted FR2387217A2 (fr) | 1977-04-11 | 1978-04-10 | Derives substitues de 9-desoxy-9-methylene prostaglandines et compositions pharmaceutiques comprenant de tels derives |
Country Status (8)
Country | Link |
---|---|
US (11) | US4098805A (fr) |
JP (1) | JPS53127438A (fr) |
BE (1) | BE865882A (fr) |
CH (1) | CH635072A5 (fr) |
DE (1) | DE2814710A1 (fr) |
FR (1) | FR2387217A2 (fr) |
GB (1) | GB1568018A (fr) |
NL (1) | NL7803434A (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2387216A2 (fr) * | 1977-04-11 | 1978-11-10 | Upjohn Co | Nouveaux derives substitues de 9-desoxy-9-methylene prostaglandines et compositions pharmaceutiques en contenant |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4169895A (en) * | 1976-09-28 | 1979-10-02 | Pfizer Inc. | Antisecretory 16,16-dimethyl-17-oxaprostaglandins |
US4276434A (en) * | 1979-04-02 | 1981-06-30 | The Upjohn Company | 19,20-Didehydro-13,14-dihydro-PG1, sulfonyl amides |
US4264523A (en) * | 1979-04-02 | 1981-04-28 | The Upjohn Company | 19,20-Didehydro-13,14-dihydro-PG1 amides |
US4264524A (en) * | 1979-04-02 | 1981-04-28 | The Upjohn Company | 19,20-Didehydro-PG1 amides |
US4264522A (en) * | 1979-04-02 | 1981-04-28 | The Upjohn Company | 19-Hydroxy-PG amides |
US4283351A (en) * | 1979-04-02 | 1981-08-11 | The Upjohn Company | 19,20-Didehydro-13,14-dihydro-PG2 amides |
US4276435A (en) * | 1979-04-02 | 1981-06-30 | The Upjohn Company | 19,20-Didehydro-PG1, sulfonyl amides |
US4283350A (en) * | 1979-04-02 | 1981-08-11 | The Upjohn Company | 19,20-Didehydro-PG2 amides |
US4278813A (en) * | 1979-04-02 | 1981-07-14 | The Upjohn Company | 19,20-Didehydro-13,14-dihydro-PG2, sulfonyl amides |
US4278812A (en) * | 1979-04-02 | 1981-07-14 | The Upjohn Company | 19,20-Didehydro-PG2 sulfonyl amides |
US4292444A (en) * | 1980-02-08 | 1981-09-29 | Pfizer Inc. | Sulfonyl prostaglandin carboxamide derivatives |
US4349690A (en) * | 1981-04-23 | 1982-09-14 | The Upjohn Company | 9-Deoxy-9-methylene-6-keto-PGE-type compounds |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2387216A2 (fr) * | 1977-04-11 | 1978-11-10 | Upjohn Co | Nouveaux derives substitues de 9-desoxy-9-methylene prostaglandines et compositions pharmaceutiques en contenant |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3954741A (en) * | 1972-06-07 | 1976-05-04 | Pfizer Inc. | N-substituted prostaglandin carboxamides |
US3981868A (en) * | 1973-05-31 | 1976-09-21 | American Cyanamid Company | Derivatives of 9-oxo-13-trans-prostenoic acid amides |
FR2239458A1 (en) * | 1973-07-31 | 1975-02-28 | Aries Robert | Prostaglandin amides - with antilipolytic, gonadotrophic, luteolytic, hypotensive and other activities associated with prostaglandins |
US3890372A (en) * | 1974-01-08 | 1975-06-17 | Upjohn Co | Amino substituted phenyl and naphthyl esters of PGF{HD 2{301 {B - type compounds |
US3927197A (en) * | 1974-04-19 | 1975-12-16 | Pfizer | Tertiary alcohol stabilized E-series prostaglandins |
US4060534A (en) * | 1976-01-23 | 1977-11-29 | The Upjohn Company | 9-Deoxy-9-methylene-PGF compounds |
-
1977
- 1977-04-11 US US05/786,250 patent/US4098805A/en not_active Expired - Lifetime
-
1978
- 1978-03-09 GB GB9340/78A patent/GB1568018A/en not_active Expired
- 1978-03-31 NL NL7803434A patent/NL7803434A/xx not_active Application Discontinuation
- 1978-04-05 DE DE19782814710 patent/DE2814710A1/de not_active Withdrawn
- 1978-04-07 US US05/894,269 patent/US4129725A/en not_active Expired - Lifetime
- 1978-04-07 US US05/894,216 patent/US4127569A/en not_active Expired - Lifetime
- 1978-04-07 US US05/894,214 patent/US4145534A/en not_active Expired - Lifetime
- 1978-04-07 US US05/894,270 patent/US4129726A/en not_active Expired - Lifetime
- 1978-04-07 US US05/894,268 patent/US4129724A/en not_active Expired - Lifetime
- 1978-04-07 US US05/894,272 patent/US4130720A/en not_active Expired - Lifetime
- 1978-04-07 US US05/894,271 patent/US4130584A/en not_active Expired - Lifetime
- 1978-04-07 US US05/894,273 patent/US4129727A/en not_active Expired - Lifetime
- 1978-04-07 US US05/894,215 patent/US4128712A/en not_active Expired - Lifetime
- 1978-04-10 CH CH384578A patent/CH635072A5/de not_active IP Right Cessation
- 1978-04-10 FR FR7810582A patent/FR2387217A2/fr active Granted
- 1978-04-11 BE BE186717A patent/BE865882A/fr not_active IP Right Cessation
- 1978-04-11 JP JP4184678A patent/JPS53127438A/ja active Pending
- 1978-04-24 US US05/899,663 patent/US4137403A/en not_active Expired - Lifetime
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2387216A2 (fr) * | 1977-04-11 | 1978-11-10 | Upjohn Co | Nouveaux derives substitues de 9-desoxy-9-methylene prostaglandines et compositions pharmaceutiques en contenant |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2387216A2 (fr) * | 1977-04-11 | 1978-11-10 | Upjohn Co | Nouveaux derives substitues de 9-desoxy-9-methylene prostaglandines et compositions pharmaceutiques en contenant |
Also Published As
Publication number | Publication date |
---|---|
US4145534A (en) | 1979-03-20 |
CH635072A5 (de) | 1983-03-15 |
US4129725A (en) | 1978-12-12 |
US4129727A (en) | 1978-12-12 |
JPS53127438A (en) | 1978-11-07 |
US4128712A (en) | 1978-12-05 |
BE865882A (fr) | 1978-10-11 |
US4137403A (en) | 1979-01-30 |
NL7803434A (nl) | 1978-10-13 |
US4098805A (en) | 1978-07-04 |
FR2387217B2 (fr) | 1981-04-30 |
US4129724A (en) | 1978-12-12 |
GB1568018A (en) | 1980-05-21 |
US4130584A (en) | 1978-12-19 |
US4129726A (en) | 1978-12-12 |
US4130720A (en) | 1978-12-19 |
DE2814710A1 (de) | 1978-10-12 |
US4127569A (en) | 1978-11-28 |
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