FR2383943A1 - Triazinones, leur procede de preparation et leur application en therapeutique - Google Patents
Triazinones, leur procede de preparation et leur application en therapeutiqueInfo
- Publication number
- FR2383943A1 FR2383943A1 FR7807170A FR7807170A FR2383943A1 FR 2383943 A1 FR2383943 A1 FR 2383943A1 FR 7807170 A FR7807170 A FR 7807170A FR 7807170 A FR7807170 A FR 7807170A FR 2383943 A1 FR2383943 A1 FR 2383943A1
- Authority
- FR
- France
- Prior art keywords
- triazinones
- therapeutics
- application
- preparation process
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- QMNWYGTWTXOQTP-UHFFFAOYSA-N 1h-triazin-6-one Chemical class O=C1C=CN=NN1 QMNWYGTWTXOQTP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
L'invention a pour objet des dérivés de triazinone de formule :
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB11757/77A GB1601132A (en) | 1977-03-19 | 1977-03-19 | Pharmacologically active triazinones |
GB1182877 | 1977-03-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2383943A1 true FR2383943A1 (fr) | 1978-10-13 |
FR2383943B1 FR2383943B1 (fr) | 1980-08-29 |
Family
ID=26248492
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7807170A Granted FR2383943A1 (fr) | 1977-03-19 | 1978-03-13 | Triazinones, leur procede de preparation et leur application en therapeutique |
Country Status (15)
Country | Link |
---|---|
US (2) | US4185103A (fr) |
JP (1) | JPS53116392A (fr) |
AT (1) | AT358593B (fr) |
AU (1) | AU514811B2 (fr) |
CA (1) | CA1124717A (fr) |
CH (1) | CH638804A5 (fr) |
DE (1) | DE2811477A1 (fr) |
FR (1) | FR2383943A1 (fr) |
IE (1) | IE46966B1 (fr) |
IL (1) | IL54111A (fr) |
IN (1) | IN147613B (fr) |
LU (1) | LU79266A1 (fr) |
NL (1) | NL7802959A (fr) |
NZ (1) | NZ186511A (fr) |
ZM (1) | ZM3278A1 (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4374836A (en) * | 1978-10-16 | 1983-02-22 | Imperial Chemical Industries Ltd. | Antisecretory heterocyclic derivatives, process for their manufacture and pharmaceutical compositions containing them |
JPS56115777A (en) * | 1980-02-19 | 1981-09-11 | Sumitomo Chem Co Ltd | 3-thiooxo-5-oxo-hexahydro-1,2,4-triazine, its preparation, herbicide and germicide comprising it as active ingredient |
IE53068B1 (en) * | 1981-06-15 | 1988-05-25 | Merck & Co Inc | Diamino isothiazole-1-oxides and -1,1-dioxides as gastic secretion inhibitors |
CA1275097A (fr) | 1984-10-02 | 1990-10-09 | Fujio Nohara | Derives de pyridyloxy |
CN103483249A (zh) * | 2012-10-09 | 2014-01-01 | 南京理工大学 | 一种2,3,5,6-四氨基吡啶盐酸盐的合成方法 |
CN104788473B (zh) * | 2015-03-25 | 2017-03-15 | 石家庄学院 | 一种具有抗菌能力的化合物及其制备方法与用途 |
EP4196793A1 (fr) | 2020-08-11 | 2023-06-21 | Université de Strasbourg | Bloqueurs de h2 ciblant des macrophages du foie pour la prévention et le traitement d'une maladie du foie et du cancer |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4005205A (en) * | 1974-04-24 | 1977-01-25 | Smith Kline & French Laboratories Limited | Compositions and methods for inhibiting H2 histamine receptors |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH288889A (de) * | 1950-08-01 | 1953-02-15 | Ag J R Geigy | Verfahren zur Herstellung eines Derivates des 1,2,4-Triazins. |
GB713540A (en) * | 1950-08-01 | 1954-08-11 | Geigy Ag J R | Improvements in and relating to 1:2:4-triazine derivatives |
DE1670912C3 (de) * | 1967-08-18 | 1981-06-11 | Bayer Ag, 5090 Leverkusen | Herbizide Mittel auf Basis von 1,2,4-Triazin-5-onen |
BE786840A (fr) * | 1971-07-29 | 1973-01-29 | Bayer Ag | Procede de preparation de 1,2,4-triazine -5-ones |
GB1419994A (en) | 1973-05-03 | 1976-01-07 | Smith Kline French Lab | Heterocyclicalkylaminotheterocyclic compounds methods for their preparation and compositions comprising them |
IN146736B (fr) | 1975-10-02 | 1979-08-25 | Smith Kline French Lab | |
MW5076A1 (en) | 1975-12-29 | 1978-02-08 | Smith Kline French Lab | Pharmacologicalle active compounds |
-
1978
- 1978-02-20 NZ NZ186511A patent/NZ186511A/xx unknown
- 1978-02-23 IL IL54111A patent/IL54111A/xx unknown
- 1978-03-02 AU AU33792/78A patent/AU514811B2/en not_active Expired
- 1978-03-03 CA CA298,146A patent/CA1124717A/fr not_active Expired
- 1978-03-13 US US05/885,940 patent/US4185103A/en not_active Expired - Lifetime
- 1978-03-13 ZM ZM7832A patent/ZM3278A1/xx unknown
- 1978-03-13 JP JP2920378A patent/JPS53116392A/ja active Pending
- 1978-03-13 FR FR7807170A patent/FR2383943A1/fr active Granted
- 1978-03-15 CH CH283778A patent/CH638804A5/de not_active IP Right Cessation
- 1978-03-16 IE IE542/78A patent/IE46966B1/en unknown
- 1978-03-16 DE DE19782811477 patent/DE2811477A1/de not_active Ceased
- 1978-03-16 IN IN201/DEL/78A patent/IN147613B/en unknown
- 1978-03-17 AT AT190478A patent/AT358593B/de not_active IP Right Cessation
- 1978-03-17 LU LU79266A patent/LU79266A1/fr unknown
- 1978-03-17 NL NL7802959A patent/NL7802959A/xx not_active Application Discontinuation
-
1979
- 1979-06-20 US US06/050,387 patent/US4220767A/en not_active Expired - Lifetime
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4005205A (en) * | 1974-04-24 | 1977-01-25 | Smith Kline & French Laboratories Limited | Compositions and methods for inhibiting H2 histamine receptors |
Also Published As
Publication number | Publication date |
---|---|
FR2383943B1 (fr) | 1980-08-29 |
US4185103A (en) | 1980-01-22 |
IL54111A0 (en) | 1978-04-30 |
AU3379278A (en) | 1979-09-06 |
JPS53116392A (en) | 1978-10-11 |
NL7802959A (nl) | 1978-09-21 |
CA1124717A (fr) | 1982-06-01 |
IN147613B (fr) | 1980-05-03 |
NZ186511A (en) | 1980-11-14 |
CH638804A5 (de) | 1983-10-14 |
ZM3278A1 (en) | 1978-12-21 |
ATA190478A (de) | 1980-02-15 |
AT358593B (de) | 1980-09-25 |
US4220767A (en) | 1980-09-02 |
AU514811B2 (en) | 1981-02-26 |
LU79266A1 (fr) | 1978-06-29 |
IL54111A (en) | 1981-07-31 |
IE780542L (en) | 1978-09-19 |
DE2811477A1 (de) | 1978-09-21 |
IE46966B1 (en) | 1983-11-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |