FR2377449A1 - Procede de fermentation pour la production de l'acide (+)-2-(5b-n-butyl-4b-hydroxy-2-oxo-tetrahydrofuranne-3b-yl)-2a-methylacetique - Google Patents

Procede de fermentation pour la production de l'acide (+)-2-(5b-n-butyl-4b-hydroxy-2-oxo-tetrahydrofuranne-3b-yl)-2a-methylacetique

Info

Publication number
FR2377449A1
FR2377449A1 FR7800816A FR7800816A FR2377449A1 FR 2377449 A1 FR2377449 A1 FR 2377449A1 FR 7800816 A FR7800816 A FR 7800816A FR 7800816 A FR7800816 A FR 7800816A FR 2377449 A1 FR2377449 A1 FR 2377449A1
Authority
FR
France
Prior art keywords
oxo
hydroxy
butyl
methylacetic
tetrahydrofuranne
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7800816A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB1310/77A external-priority patent/GB1593389A/en
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of FR2377449A1 publication Critical patent/FR2377449A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/933—Penicillium

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne l'industrie pharmaceutique. Elle a pour objet un procédé pour produire par fermentation l'acide (+)-2-(5 beta -n-butyl-4 beta -hydroxy-2-oxo-tétrahydrofuranne- 3 beta -yl)-2 alpha -méthylacétique suivant lequel on cultive une souche d'une espèce du genre Penicillium ou du genre Aspergillus produisant du dihydrocanadensolide dans un milieu nutritif aqueux. Ce produit est préféré pour le traitement des ulcères gastrointestinaux.
FR7800816A 1977-01-13 1978-01-12 Procede de fermentation pour la production de l'acide (+)-2-(5b-n-butyl-4b-hydroxy-2-oxo-tetrahydrofuranne-3b-yl)-2a-methylacetique Withdrawn FR2377449A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1310/77A GB1593389A (en) 1977-01-13 1977-01-13 Fermentation process
GB1062277 1977-03-14

Publications (1)

Publication Number Publication Date
FR2377449A1 true FR2377449A1 (fr) 1978-08-11

Family

ID=26236635

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7800816A Withdrawn FR2377449A1 (fr) 1977-01-13 1978-01-12 Procede de fermentation pour la production de l'acide (+)-2-(5b-n-butyl-4b-hydroxy-2-oxo-tetrahydrofuranne-3b-yl)-2a-methylacetique

Country Status (16)

Country Link
US (1) US4178213A (fr)
JP (1) JPS53109995A (fr)
AU (1) AU3225078A (fr)
CA (1) CA1108078A (fr)
DE (1) DE2801399A1 (fr)
DK (1) DK4978A (fr)
ES (1) ES465948A1 (fr)
FI (1) FI780041A (fr)
FR (1) FR2377449A1 (fr)
GR (1) GR62086B (fr)
IE (1) IE45855B1 (fr)
IT (1) IT1158425B (fr)
NL (1) NL7800243A (fr)
NO (1) NO774408L (fr)
NZ (1) NZ186138A (fr)
SE (1) SE7800363L (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004323808B2 (en) * 2004-10-05 2011-11-17 Biocon Limited Process for producing mycophenolic acid using penicillium arenicola BICC 7673
CN101831470A (zh) * 2010-04-26 2010-09-15 华南理工大学 二氢双环内酯的制备方法及其应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1434595A (en) * 1973-03-29 1976-05-05 Ici Ltd Pharmaceutical compositions

Also Published As

Publication number Publication date
DK4978A (da) 1978-07-14
NL7800243A (nl) 1978-07-17
NZ186138A (en) 1979-06-19
DE2801399A1 (de) 1978-07-20
IE45855B1 (en) 1982-12-15
AU3225078A (en) 1979-07-19
IT1158425B (it) 1987-02-18
IT7819260A0 (it) 1978-01-13
SE7800363L (sv) 1978-07-14
ES465948A1 (es) 1979-01-01
GR62086B (en) 1979-02-21
JPS53109995A (en) 1978-09-26
IE45855L (en) 1978-07-13
FI780041A (fi) 1978-07-14
US4178213A (en) 1979-12-11
NO774408L (no) 1978-07-14
CA1108078A (fr) 1981-09-01

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Legal Events

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