FR2375176A1 - Procede pour preparer des quinones - Google Patents

Procede pour preparer des quinones

Info

Publication number
FR2375176A1
FR2375176A1 FR7731223A FR7731223A FR2375176A1 FR 2375176 A1 FR2375176 A1 FR 2375176A1 FR 7731223 A FR7731223 A FR 7731223A FR 7731223 A FR7731223 A FR 7731223A FR 2375176 A1 FR2375176 A1 FR 2375176A1
Authority
FR
France
Prior art keywords
prenyl
hydroquinone
preparing
side chain
quinones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7731223A
Other languages
English (en)
Other versions
FR2375176B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP12573676A external-priority patent/JPS588371B2/ja
Priority claimed from JP8767577A external-priority patent/JPS5422331A/ja
Priority claimed from JP8767477A external-priority patent/JPS5422330A/ja
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of FR2375176A1 publication Critical patent/FR2375176A1/fr
Application granted granted Critical
Publication of FR2375176B1 publication Critical patent/FR2375176B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
    • C07C46/06—Preparation of quinones by oxidation giving rise to quinoid structures of at least one hydroxy group on a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C07C46/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/28—Quinones containing groups having oxygen atoms singly bound to carbon atoms with monocyclic quinoid structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/32—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Procédé pour préparer des quinones. Ce nouveau procédé consiste à préparer des dérivés hydroquinone et quinone par une réaction de couplage régio-spécifique et stéréo-spécifique de dérivés de l'hydroquinone, ayant une chaîne latérale terminale (poly)prényle activée, avec un dérivé prényle. Ce procédé permet d'obtenir divers dérivés hydroquinone et quinone avec un bon rendement, ayant une longueur quelconque prényle de la chaîne latérale.
FR7731223A 1976-10-19 1977-10-17 Procede pour preparer des quinones Granted FR2375176A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP12573676A JPS588371B2 (ja) 1976-10-19 1976-10-19 ハロゲノヒドロキノン誘導体
JP8767577A JPS5422331A (en) 1977-07-20 1977-07-20 Preparation of quinones
JP8767477A JPS5422330A (en) 1977-07-20 1977-07-20 Preparation of quinones

Publications (2)

Publication Number Publication Date
FR2375176A1 true FR2375176A1 (fr) 1978-07-21
FR2375176B1 FR2375176B1 (fr) 1983-08-26

Family

ID=27305574

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7731223A Granted FR2375176A1 (fr) 1976-10-19 1977-10-17 Procede pour preparer des quinones

Country Status (7)

Country Link
US (1) US4199531A (fr)
CA (1) CA1091680A (fr)
CH (1) CH636836A5 (fr)
DE (1) DE2746398A1 (fr)
FR (1) FR2375176A1 (fr)
GB (1) GB1596759A (fr)
NL (1) NL7711504A (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2435466A1 (fr) * 1978-08-02 1980-04-04 Kuraray Co Derives de l'hydroquinone et leur procede de preparation
JPS5910541A (ja) * 1982-07-09 1984-01-20 Takeda Chem Ind Ltd キノン化合物
US4849442A (en) * 1983-12-14 1989-07-18 The Upjohn Company Method for treating or preventing deep vein thrombosis using lipoxygenase inhibitors
US4737519A (en) * 1983-12-14 1988-04-12 The Upjohn Company Substituted naphthalenes, indoles, benzofurans, and benzothiophenes as lipoxygenase inhibitors
US4791138A (en) * 1983-12-14 1988-12-13 The Upjohn Company Method for treating or preventing deep vein thrombosis using lipoxygenase inhibitors
US4849445A (en) * 1983-12-14 1989-07-18 The Upjohn Company Method for treating or preventing deep vein thrombosis using lipoxygenase inhibitors
CA2207093A1 (fr) * 1994-12-06 1996-06-13 Ryan Pharmaceuticals, Inc. Compositions a base d'ubiquinones solubles dans l'eau, precurseurs de medicaments, ainsi que les procedes y ayant trait
DE10057415B4 (de) * 2000-11-20 2004-02-12 Friz Biochem Gmbh Verfahren zur Herstellung von Chinon-Derivaten und deren Verwendung
US7439402B2 (en) * 2005-09-15 2008-10-21 Eisai R&D Management Co., Ltd. Method for producing quinone compound
EP2093222A1 (fr) * 2008-02-22 2009-08-26 Newbiotechnic, S.A. Époxydes de polysoprénoïde utile pour diminuer le cholestérol et/ou augmenter la biosynthèse de coenzyme Q
GB0817528D0 (en) * 2008-09-24 2008-10-29 Syntavit As Process
PL401195A1 (pl) 2012-10-12 2014-04-14 Instytut Farmaceutyczny Sposób wytwarzania witaminy K2 w formie MK-7
EP2868658B1 (fr) * 2013-11-01 2018-05-02 Dilip Mehta Procédé de préparation de dérivés de quinone stéréospécifiques
WO2019194690A1 (fr) 2018-04-06 2019-10-10 Instytut Farmaceutyczny Procédé de préparation de dérivés de vitamine k2
WO2021071372A1 (fr) 2019-10-07 2021-04-15 Sieć Badawcza Łukasiewicz - Instytut Farmaceutyczny Procédé de préparation de dérivés de vitamine k2
PL243187B1 (pl) 2020-07-16 2023-07-10 Vitasynth Spolka Z Ograniczona Odpowiedzialnoscia Sposób i związki pośrednie do otrzymywania menachinonu MK-7
CN112209814B (zh) * 2020-10-21 2023-05-26 黄冈鲁班药业股份有限公司 一种合成维生素k2的新方法
US11912654B2 (en) 2021-09-03 2024-02-27 Synergia Life Sciences Pvt. Ltd. Process for stereospecific synthesis of vitamin K2 and its novel intermediates

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3068295A (en) * 1962-12-11 diether groups
US3781313A (en) * 1971-01-20 1973-12-25 Rhone Poulenc Sa Sulfone intermediates for the synthesis of vitamin a
US4038323A (en) * 1971-05-19 1977-07-26 Rhone-Poulenc S.A. Alkenyl aryl sulfones
BE794872A (fr) 1972-02-02 1973-08-01 Rhone Poulenc Sa Nouvelles sulfones derivees de dimethyl-1,5 hexadiene-1,5 ylene
JPS5147697B2 (fr) * 1972-08-26 1976-12-16
US3960967A (en) * 1973-09-14 1976-06-01 Hoffmann-La Roche Inc. Process for producing a sulfone derivative of vitamin A alcohol
US4089873A (en) * 1975-01-13 1978-05-16 The Regents Of The University Of California Preparation of menaquinones

Also Published As

Publication number Publication date
US4199531A (en) 1980-04-22
NL7711504A (nl) 1978-04-21
CH636836A5 (de) 1983-06-30
DE2746398A1 (de) 1978-04-20
FR2375176B1 (fr) 1983-08-26
CA1091680A (fr) 1980-12-16
GB1596759A (en) 1981-08-26

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