FR2374332A1 - Procede de production de 3', 4'-dideoxykanamycine b - Google Patents

Procede de production de 3', 4'-dideoxykanamycine b

Info

Publication number
FR2374332A1
FR2374332A1 FR7737423A FR7737423A FR2374332A1 FR 2374332 A1 FR2374332 A1 FR 2374332A1 FR 7737423 A FR7737423 A FR 7737423A FR 7737423 A FR7737423 A FR 7737423A FR 2374332 A1 FR2374332 A1 FR 2374332A1
Authority
FR
France
Prior art keywords
dideoxykanamycin
eno
kanamycin
production process
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7737423A
Other languages
English (en)
Other versions
FR2374332B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Publication of FR2374332A1 publication Critical patent/FR2374332A1/fr
Application granted granted Critical
Publication of FR2374332B1 publication Critical patent/FR2374332B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne la production de 3', 4'-didéoxykanamycine B. Le procédé consiste à faire réagir un dérivé protégé de 3'-4'-didéoxy-3'-éno-kanamycine B avec un métal alcalin ou alcalino-terreux en présence d'ammoniac liquide pour en éliminer les loupes protecteurs, puis à faire réagir la 3', 4'didéoxy-3'-éno-kanamycine B avec l'hydrogène en présence d'un catalyseur d'hydrogénation pour hydrogéner la liaison insaturée en 3', 4' et pour produire ainsi la 3', 4'-didéoxykanamycine B. La 3', 4'-didéoxykanamycine B est un antibiotique semi-synthétique doué d'une grande activité antibactérienne.
FR7737423A 1976-12-16 1977-12-12 Procede de production de 3', 4'-dideoxykanamycine b Granted FR2374332A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP51150334A JPS6052719B2 (ja) 1976-12-16 1976-12-16 ３′，４′−ジデオキシカナマイシンｂの新規な製造法

Publications (2)

Publication Number Publication Date
FR2374332A1 true FR2374332A1 (fr) 1978-07-13
FR2374332B1 FR2374332B1 (fr) 1982-07-09

Family

ID=15494728

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7737423A Granted FR2374332A1 (fr) 1976-12-16 1977-12-12 Procede de production de 3', 4'-dideoxykanamycine b

Country Status (16)

Country Link
US (1) US4169939A (fr)
JP (1) JPS6052719B2 (fr)
AT (1) AT356815B (fr)
AU (1) AU505974B2 (fr)
BE (1) BE861958A (fr)
CA (1) CA1095903A (fr)
CH (1) CH637402A5 (fr)
DE (1) DE2756057A1 (fr)
ES (2) ES465168A1 (fr)
FR (1) FR2374332A1 (fr)
GB (1) GB1589936A (fr)
HU (1) HU177398B (fr)
IE (1) IE45912B1 (fr)
NL (1) NL7713775A (fr)
SE (1) SE442512B (fr)
YU (1) YU40179B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5581897A (en) * 1978-12-14 1980-06-20 Microbial Chem Res Found Preparation of 1-n-isoseryl-or 1-n-(l-4-amino-2-hydroxybutyryl)-3',4'-dideoxykanamycin b
JPS55105699A (en) * 1979-02-05 1980-08-13 Microbial Chem Res Found 3',4'-dideoxykanamycin a and its 1-n-aminoalkanoyl derivative
CN101575354B (zh) * 2009-05-26 2013-03-13 北京化工大学 阿贝卡星及其中间体地贝卡星的合成方法
CN102786564B (zh) * 2011-05-19 2015-05-13 北京化工大学 阿贝卡星及其中间体地贝卡星的合成新方法
CN106946957B (zh) * 2017-05-11 2019-11-08 常州方圆制药有限公司 阿贝卡星中间体的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1349302A (en) * 1970-07-29 1974-04-03 Microbial Chem Res Found 3,-4,-dideoxykanamycin b active against resistant bacteria and its synthesis
US3929762A (en) * 1972-08-23 1975-12-30 Microbial Chem Res Found 3{40 -Deoxy derivatives of neamine and its related aminoglycosidic antibiotics, and the production thereof
US3868360A (en) * 1972-10-24 1975-02-25 Schering Corp Process for preparing 2-deroxy-3-desamino-2,3-epimino-aminoglycosides and intermediates useful therein
JPS6029720B2 (ja) * 1975-12-11 1985-07-12 財団法人微生物化学研究会 ３′，４′‐ジデオキシカナマイシンｂの新規な製造法

Also Published As

Publication number Publication date
JPS5377039A (en) 1978-07-08
SE442512B (sv) 1986-01-13
CH637402A5 (de) 1983-07-29
DE2756057A1 (de) 1978-06-29
YU40179B (en) 1985-08-31
GB1589936A (en) 1981-05-20
FR2374332B1 (fr) 1982-07-09
AT356815B (de) 1980-05-27
YU298677A (en) 1982-10-31
ES474759A1 (es) 1979-04-01
IE45912L (en) 1978-06-16
AU3061077A (en) 1979-05-24
IE45912B1 (en) 1982-12-29
BE861958A (fr) 1978-04-14
ES465168A1 (es) 1979-01-01
AU505974B2 (en) 1979-12-06
NL7713775A (nl) 1978-06-20
US4169939A (en) 1979-10-02
ATA899477A (de) 1979-10-15
JPS6052719B2 (ja) 1985-11-20
DE2756057C2 (fr) 1988-09-29
SE7714304L (sv) 1978-06-17
HU177398B (en) 1981-12-28
CA1095903A (fr) 1981-02-17

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