FR2371926A1 - Composition pharmaceutique a base d'insuline pour usage rectal - Google Patents
Composition pharmaceutique a base d'insuline pour usage rectalInfo
- Publication number
- FR2371926A1 FR2371926A1 FR7735193A FR7735193A FR2371926A1 FR 2371926 A1 FR2371926 A1 FR 2371926A1 FR 7735193 A FR7735193 A FR 7735193A FR 7735193 A FR7735193 A FR 7735193A FR 2371926 A1 FR2371926 A1 FR 2371926A1
- Authority
- FR
- France
- Prior art keywords
- compsn
- hypoglycaemic
- units
- absorption accelerator
- contg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
- 102000004877 Insulin Human genes 0.000 title abstract 2
- 108090001061 Insulin Proteins 0.000 title abstract 2
- 239000003655 absorption accelerator Substances 0.000 title abstract 2
- 239000003613 bile acid Substances 0.000 title abstract 2
- 230000002218 hypoglycaemic effect Effects 0.000 title abstract 2
- 229940125396 insulin Drugs 0.000 title abstract 2
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 239000004094 surface-active agent Substances 0.000 title 1
- 238000002347 injection Methods 0.000 abstract 2
- 239000007924 injection Substances 0.000 abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 241000283973 Oryctolagus cuniculus Species 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- -1 alkali metal salts Chemical class 0.000 abstract 1
- 125000000129 anionic group Chemical group 0.000 abstract 1
- 239000003945 anionic surfactant Substances 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 239000003093 cationic surfactant Substances 0.000 abstract 1
- 235000005687 corn oil Nutrition 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 229940126904 hypoglycaemic agent Drugs 0.000 abstract 1
- 239000002563 ionic surfactant Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002736 nonionic surfactant Substances 0.000 abstract 1
- 125000006353 oxyethylene group Chemical group 0.000 abstract 1
- 229940051841 polyoxyethylene ether Drugs 0.000 abstract 1
- 229920000056 polyoxyethylene ether Polymers 0.000 abstract 1
- JAJWGJBVLPIOOH-IZYKLYLVSA-M sodium taurocholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 JAJWGJBVLPIOOH-IZYKLYLVSA-M 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP50117810A JPS5244222A (en) | 1975-09-30 | 1975-09-30 | Method of making insulin preparations for rectal application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2371926A1 true FR2371926A1 (fr) | 1978-06-23 |
| FR2371926B1 FR2371926B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1981-06-19 |
Family
ID=14720818
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7735193A Granted FR2371926A1 (fr) | 1975-09-30 | 1977-11-23 | Composition pharmaceutique a base d'insuline pour usage rectal |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPS5244222A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) |
| FR (1) | FR2371926A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0213552A3 (en) * | 1985-08-23 | 1987-09-02 | Fujisawa Pharmaceutical Co., Ltd. | Oily suspension for intrarectal infusion |
| EP0338081A4 (en) * | 1987-09-25 | 1990-12-19 | Fujisawa Pharmaceutical Co., Ltd. | Oily rectal instillation |
| EP0561330A1 (de) * | 1992-03-17 | 1993-09-22 | Pharmed Dr. Liedtke Gmbh | Topische Arzneiformen mit Insulin |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5287218A (en) * | 1976-01-01 | 1977-07-20 | Yamanouchi Pharmaceut Co Ltd | Insulin composition for rectal administration |
| JPS5517342A (en) * | 1978-07-25 | 1980-02-06 | Toyama Chem Co Ltd | Cephalosporin composition for rectal administaration |
| JPS5675437A (en) * | 1979-11-21 | 1981-06-22 | Asahi Denka Kogyo Kk | Suppository base |
| JPS6076645A (ja) * | 1983-10-03 | 1985-05-01 | Hajime Kano | 粉塵濃度測定装置 |
| WO1989003671A1 (en) * | 1987-10-29 | 1989-05-05 | Dainippon Pharmaceutical Co., Ltd. | Sustained-release preparation |
| JPH0655555U (ja) * | 1992-04-22 | 1994-08-02 | 純江 齋藤 | タワシ |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL45481C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1900-01-01 | |||
| CH211204A (de) * | 1938-12-13 | 1940-08-31 | Chem Ind Basel | Verfahren zur Herstellung einer Suppositoriengrundmasse. |
| FR2183677A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1972-03-06 | 1973-12-21 | Takeda Chemical Industries Ltd |
-
1975
- 1975-09-30 JP JP50117810A patent/JPS5244222A/ja active Granted
-
1977
- 1977-11-23 FR FR7735193A patent/FR2371926A1/fr active Granted
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL45481C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1900-01-01 | |||
| CH211204A (de) * | 1938-12-13 | 1940-08-31 | Chem Ind Basel | Verfahren zur Herstellung einer Suppositoriengrundmasse. |
| FR2183677A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1972-03-06 | 1973-12-21 | Takeda Chemical Industries Ltd |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0213552A3 (en) * | 1985-08-23 | 1987-09-02 | Fujisawa Pharmaceutical Co., Ltd. | Oily suspension for intrarectal infusion |
| EP0338081A4 (en) * | 1987-09-25 | 1990-12-19 | Fujisawa Pharmaceutical Co., Ltd. | Oily rectal instillation |
| EP0561330A1 (de) * | 1992-03-17 | 1993-09-22 | Pharmed Dr. Liedtke Gmbh | Topische Arzneiformen mit Insulin |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS558486B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1980-03-04 |
| FR2371926B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1981-06-19 |
| JPS5244222A (en) | 1977-04-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |