FR2369264A1 - 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylate d'isopropyle et d - Google Patents

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylate d'isopropyle et d

Info

Publication number
FR2369264A1
FR2369264A1 FR7732558A FR7732558A FR2369264A1 FR 2369264 A1 FR2369264 A1 FR 2369264A1 FR 7732558 A FR7732558 A FR 7732558A FR 7732558 A FR7732558 A FR 7732558A FR 2369264 A1 FR2369264 A1 FR 2369264A1
Authority
FR
France
Prior art keywords
isopropyl
nitrophenyl
dihydro
pyridine
dimethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7732558A
Other languages
English (en)
Other versions
FR2369264B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of FR2369264A1 publication Critical patent/FR2369264A1/fr
Application granted granted Critical
Publication of FR2369264B1 publication Critical patent/FR2369264B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La présente invention concerne à titre de composé nouveau le 1,4-dihydro-2,6-diméthyl-4-(3-nitrophényl)-3,5-pyridine-carboxylate d'isopropyle et de 2-propoxyéthyle. On obtient ce composé par un procédé dont l'une des variantes consiste à faire réagir le 3'-nitrobenzylidène-acétylacétate d'isopropyle avec le bêta-aminocrotonate de 2-propoxyéthyle. Le composé de l'invention peut être utilisé comme médicament. Il produit lorsqu'il est administré par voie entérale et parentérale une vasodilatation intense et de longue durée et peut, de ce fait, être utilisé pour la thérapie et la prophylaxie de troubles de la circulation périphérique.
FR7732558A 1976-10-30 1977-10-28 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylate d'isopropyle et d Granted FR2369264A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2650013A DE2650013C3 (de) 1976-10-30 1976-10-30 1.4-Dihydro-2.6-dimethyl-4-(3-nitrophenyl)-3.5-pyridindicarbonsäureisopropyl-(2-propoxy-äthyl)-ester, Verfahren zu seiner Herstellung sowie ihn enthaltende Arzneimittel

Publications (2)

Publication Number Publication Date
FR2369264A1 true FR2369264A1 (fr) 1978-05-26
FR2369264B1 FR2369264B1 (fr) 1980-06-13

Family

ID=5992142

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7732558A Granted FR2369264A1 (fr) 1976-10-30 1977-10-28 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxylate d'isopropyle et d

Country Status (14)

Country Link
US (1) US4166855A (fr)
JP (1) JPS5356672A (fr)
AT (1) AT357162B (fr)
AU (1) AU507892B2 (fr)
BE (1) BE860248A (fr)
CA (1) CA1070314A (fr)
CH (2) CH633265A5 (fr)
DE (1) DE2650013C3 (fr)
ES (1) ES463646A1 (fr)
FI (1) FI60705C (fr)
FR (1) FR2369264A1 (fr)
GB (1) GB1568740A (fr)
NL (1) NL7711827A (fr)
SE (1) SE433211B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57175164A (en) * 1981-04-18 1982-10-28 Banyu Pharmaceut Co Ltd 1,4-dihydropyridine derivative and its preparation
DE3208628A1 (de) * 1982-03-10 1983-09-22 Bayer Ag, 5090 Leverkusen Neue verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
JPS58185821U (ja) * 1982-06-02 1983-12-10 日産自動車株式会社 ウインドシ−ルド
DE3248548A1 (de) * 1982-12-29 1984-07-05 Heinrich Mack Nachf., 7918 Illertissen Acylderivate von 1,4:3,6-dianhydro-hexiten, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3316510A1 (de) * 1983-05-06 1984-11-08 Bayer Ag Parenterale formulierung von nimodipin, ein verfahren zu ihrer herstellung sowie ihre verwendung bei der bekaempfung von erkrankungen
JPS60214778A (ja) * 1984-03-08 1985-10-28 Suntory Ltd Ν置換３，４−ジヒドロピリミジン誘導体ならびにその製造法および用途
DE3544692A1 (de) * 1985-12-18 1987-06-19 Bayer Ag Dihydropyridinspray, verfahren zu seiner herstellung und seine pharmazeutische verwendung
LV12200B (lv) * 1997-07-03 1999-04-20 Gunārs DUBURS Antidiabētisks līdzeklis

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2117573A1 (de) * 1971-04-10 1972-10-19 Farbenfabriken Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von neuen unsymmetrischen 1,4-Dihydropyridindicarbonsäureestern, sowie ihre Verwendung als Arzneimittel
FR2132830A1 (fr) * 1971-04-10 1972-11-24 Bayer Ag

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670827C3 (de) * 1967-03-20 1974-10-24 Bayer Ag, 5090 Leverkusen 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2117573A1 (de) * 1971-04-10 1972-10-19 Farbenfabriken Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von neuen unsymmetrischen 1,4-Dihydropyridindicarbonsäureestern, sowie ihre Verwendung als Arzneimittel
FR2132830A1 (fr) * 1971-04-10 1972-11-24 Bayer Ag

Also Published As

Publication number Publication date
JPS577149B2 (fr) 1982-02-09
AU3014777A (en) 1979-05-03
FI773208A (fi) 1978-05-01
SE7712108L (sv) 1978-05-01
DE2650013B2 (de) 1980-06-12
CH633265A5 (de) 1982-11-30
US4166855A (en) 1979-09-04
SE433211B (sv) 1984-05-14
FR2369264B1 (fr) 1980-06-13
FI60705C (fi) 1982-03-10
CH635078A5 (de) 1983-03-15
BE860248A (fr) 1978-04-28
DE2650013C3 (de) 1981-04-02
FI60705B (fi) 1981-11-30
AU507892B2 (en) 1980-02-28
AT357162B (de) 1980-06-25
ATA773177A (de) 1979-11-15
ES463646A1 (es) 1978-07-16
JPS5356672A (en) 1978-05-23
CA1070314A (fr) 1980-01-22
GB1568740A (en) 1980-06-04
DE2650013A1 (de) 1978-05-11
NL7711827A (nl) 1978-05-03

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