FR2366291A1 - Derives d'acide folique a marquage radioactif et leur procede de preparation - Google Patents

Derives d'acide folique a marquage radioactif et leur procede de preparation

Info

Publication number
FR2366291A1
FR2366291A1 FR7729364A FR7729364A FR2366291A1 FR 2366291 A1 FR2366291 A1 FR 2366291A1 FR 7729364 A FR7729364 A FR 7729364A FR 7729364 A FR7729364 A FR 7729364A FR 2366291 A1 FR2366291 A1 FR 2366291A1
Authority
FR
France
Prior art keywords
acid derivatives
folic acid
radioactive
preparation process
labeled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7729364A
Other languages
English (en)
Other versions
FR2366291B3 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Becton Dickinson and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Publication of FR2366291A1 publication Critical patent/FR2366291A1/fr
Application granted granted Critical
Publication of FR2366291B3 publication Critical patent/FR2366291B3/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals

Abstract

Dans les dérivés de l'acide folique selon l'invention, le radical alpha -carboxy du fragment glutamyle est substitué par un radical pouvant être marqué par de l'iode radioactif, tel qu'un radical tyrosyle ou histidyle substitué ou non substitué Ces dérivés à marquage radioactif sont utiles notamment comme marqueurs pour la détermination des folates.
FR7729364A 1976-09-29 1977-09-29 Derives d'acide folique a marquage radioactif et leur procede de preparation Granted FR2366291A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/727,408 US4276280A (en) 1976-09-29 1976-09-29 Radiolabeled derivatives of folic acid

Publications (2)

Publication Number Publication Date
FR2366291A1 true FR2366291A1 (fr) 1978-04-28
FR2366291B3 FR2366291B3 (fr) 1980-07-18

Family

ID=24922525

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7729364A Granted FR2366291A1 (fr) 1976-09-29 1977-09-29 Derives d'acide folique a marquage radioactif et leur procede de preparation

Country Status (10)

Country Link
US (1) US4276280A (fr)
JP (1) JPS5353696A (fr)
AU (1) AU2911077A (fr)
BE (1) BE859064A (fr)
CA (1) CA1137977A (fr)
DE (1) DE2741677A1 (fr)
FR (1) FR2366291A1 (fr)
GB (1) GB1581075A (fr)
IT (1) IT1087384B (fr)
SE (1) SE7710791L (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105008930A (zh) * 2012-12-27 2015-10-28 生物梅里埃公司 在测定叶酸的情形中特别有用的叶酸衍生物

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4298735A (en) * 1979-04-30 1981-11-03 Union Carbide Corporation Folic acid derivatives
GB2056459B (en) * 1979-07-04 1983-03-09 Daiichi Radioisotope Lab Pterin derivatives and an assay method for determining pterins
US4314988A (en) * 1979-10-31 1982-02-09 Baker Instruments Corp. Folic acid derivatives and process for preparation
CA1180273A (fr) * 1981-06-22 1985-01-02 Technicon Instruments Corporation Dosage de la vitamine b in12 xx
US5334369A (en) * 1991-06-11 1994-08-02 Medical University Of South Carolina Platelet receptor antagonists useful in detecting intravascular platelet aggregation
US5413778A (en) * 1992-10-05 1995-05-09 The Regents Of The University Of Michigan Labelled monocyte chemoattractant protein material and medical uses thereof
US5605671A (en) * 1992-10-05 1997-02-25 The Regents Of The University Of Michigan Radiolabeled neutrophil activating peptides for imaging
AU5537994A (en) * 1992-10-22 1994-05-09 Mallinckrodt Medical, Inc. Therapeutic treatment for inhibiting vascular restenosis
US5800979A (en) * 1994-12-01 1998-09-01 Kolhouse; J. Fred Gas chromatography/mass spectrometric determination of folic acid coenzymes
US6376210B1 (en) 1999-07-06 2002-04-23 General Atomics Methods and compositions for assaying analytes
US7192729B2 (en) 1999-07-06 2007-03-20 General Atomics Methods for assaying homocysteine
DK2146944T3 (da) * 2007-04-11 2014-02-03 Merck & Cie Fremgangsmåde til fremstillingen af 18f-mærkede folater
CN102827166A (zh) * 2007-04-11 2012-12-19 默克和西伊公司 18f-标记的叶酸类
ES2548140T3 (es) 2008-10-10 2015-10-14 Merck & Cie Folatos marcados con 18F como radiotrazadores PET
AU2012298546A1 (en) 2011-08-22 2014-02-20 Merck & Cie 18F-saccharide-folates

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3989812A (en) * 1974-08-09 1976-11-02 Smithkline Instruments, Inc. Folic acid derivatives and use in radio-assay
US3988431A (en) * 1974-12-12 1976-10-26 Becton, Dickinson And Company Radioassay of folates

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105008930A (zh) * 2012-12-27 2015-10-28 生物梅里埃公司 在测定叶酸的情形中特别有用的叶酸衍生物
CN105008930B (zh) * 2012-12-27 2018-05-29 生物梅里埃公司 在测定叶酸的情形中特别有用的叶酸衍生物
US10640505B2 (en) 2012-12-27 2020-05-05 bioMérieux Folate derivatives, useful in particular in the context of the folate assay
US11535620B2 (en) 2012-12-27 2022-12-27 bioMérieux Folate derivatives, useful in particular in the context of the folate assay

Also Published As

Publication number Publication date
AU2911077A (en) 1979-04-05
IT1087384B (it) 1985-06-04
US4276280A (en) 1981-06-30
DE2741677A1 (de) 1978-03-30
CA1137977A (fr) 1982-12-21
FR2366291B3 (fr) 1980-07-18
GB1581075A (en) 1980-12-10
SE7710791L (sv) 1978-03-30
BE859064A (fr) 1978-01-16
JPS5353696A (en) 1978-05-16

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