FR2364889A1 - Pentapeptide encephalin analogues - for use as analgesics and antidepressants - Google Patents

Pentapeptide encephalin analogues - for use as analgesics and antidepressants

Info

Publication number
FR2364889A1
FR2364889A1 FR7726563A FR7726563A FR2364889A1 FR 2364889 A1 FR2364889 A1 FR 2364889A1 FR 7726563 A FR7726563 A FR 7726563A FR 7726563 A FR7726563 A FR 7726563A FR 2364889 A1 FR2364889 A1 FR 2364889A1
Authority
FR
France
Prior art keywords
analogues
encephalin
pentapeptide
antidepressants
analgesics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7726563A
Other languages
French (fr)
Other versions
FR2364889B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of FR2364889A1 publication Critical patent/FR2364889A1/en
Application granted granted Critical
Publication of FR2364889B1 publication Critical patent/FR2364889B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/70—Enkephalins
    • C07K14/702—Enkephalins with at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Pentapeptides of formula (I) and their salts are new: H-Tyr-X-Gly-Phe-Met-Y (I), (where X is D-Ala, D-Leu, D-Ile, D-Val, D-Phe, D-Tyr, D-Trp, D-Ser, D-Thr, D-Met, D-Glu, D-Gln, D-Asp, D-Asn, D-Lys or D-Arg; Y is NH2 or OH). (I) are analogues of methionine encephalin (H-Tyr-Gly-Gly-Phe-Met-OH) with analgesic and antidepressant activity- Cpd. (I); X = D-Ala, Y = OH) is stated to be a considerably more powerful analgesic than morphine.
FR7726563A 1976-09-01 1977-09-01 Pentapeptide encephalin analogues - for use as analgesics and antidepressants Granted FR2364889A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71939776A 1976-09-01 1976-09-01

Publications (2)

Publication Number Publication Date
FR2364889A1 true FR2364889A1 (en) 1978-04-14
FR2364889B1 FR2364889B1 (en) 1981-06-19

Family

ID=24889909

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7726563A Granted FR2364889A1 (en) 1976-09-01 1977-09-01 Pentapeptide encephalin analogues - for use as analgesics and antidepressants
FR7816543A Withdrawn FR2381746A1 (en) 1976-09-01 1978-06-02 NEW ENCEPHALINIC DERIVATIVES OF METHIONINE

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR7816543A Withdrawn FR2381746A1 (en) 1976-09-01 1978-06-02 NEW ENCEPHALINIC DERIVATIVES OF METHIONINE

Country Status (15)

Country Link
JP (1) JPS5356634A (en)
AU (1) AU2844577A (en)
BE (1) BE858344A (en)
DE (1) DE2739440A1 (en)
DK (1) DK386677A (en)
ES (1) ES462221A1 (en)
FR (2) FR2364889A1 (en)
IL (1) IL52870A0 (en)
NL (1) NL7709653A (en)
NO (1) NO773013L (en)
PL (1) PL200605A1 (en)
PT (1) PT66982B (en)
SE (1) SE7709806L (en)
YU (1) YU208677A (en)
ZA (1) ZA775285B (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2359817A1 (en) * 1976-07-27 1978-02-24 Reckitt & Colmann Prod Ltd Peptide cpds. contg. tyrosine, glycine, phenylalanine and d-amino acid - local anaesthetics, smooth muscle relaxants, adrenergic neutron blockers, beta-stimulants etc.
FR2365553A1 (en) * 1976-09-27 1978-04-21 Lilly Co Eli AMID DERIVATIVES OF PENTAPEPTIDES AND TETRAPEPTIDES AND THEIR USE AS MEDICINAL PRODUCTS
EP0002236A1 (en) * 1977-11-24 1979-06-13 The Wellcome Foundation Limited Peptides, their salts, their acid addition salts, pharmaceutical formulations containing them and their use as morphine antagonists and anaesthetics
EP0008196A1 (en) * 1978-08-08 1980-02-20 American Home Products Corporation Pentapeptides, processes for their preparation, intermediates used in such processes, use in pharmaceutical compositions and compositions containing them
FR2465713A1 (en) * 1979-09-20 1981-03-27 Erba Farmitalia NOVEL BIOLOGICALLY ACTIVE PEPTIDES AND THEIR USE AS MEDICAMENTS

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1175810A (en) * 1979-03-30 1984-10-09 Frank A. Momany Synthetic peptides having pituitary growth hormone releasing activity
DE2933947A1 (en) * 1979-08-22 1981-03-12 Hoechst Ag, 6000 Frankfurt NEW PEPTIDAMIDES AND METHOD FOR THEIR PRODUCTION.
JPS5645450A (en) * 1979-09-21 1981-04-25 Dai Ichi Seiyaku Co Ltd Pentapeptide compound
DE2941790A1 (en) * 1979-10-16 1981-04-30 Hoechst Ag, 6000 Frankfurt USE OF MOTIVITY-INCREASING PEPTIDES

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1532181A (en) * 1976-02-02 1978-11-15 Beckman Instruments Inc Pentapetides and a method of preparing them
NZ183712A (en) * 1976-04-08 1979-10-25 Ici Ltd Polypeptide analogues of enkephalins, and pharmaceutical compositions
US4259234A (en) * 1976-09-27 1981-03-31 Eli Lilly And Company Analgesic compounds

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CA1977 *
EXRV/76 *
NV2030/77 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2359817A1 (en) * 1976-07-27 1978-02-24 Reckitt & Colmann Prod Ltd Peptide cpds. contg. tyrosine, glycine, phenylalanine and d-amino acid - local anaesthetics, smooth muscle relaxants, adrenergic neutron blockers, beta-stimulants etc.
FR2365553A1 (en) * 1976-09-27 1978-04-21 Lilly Co Eli AMID DERIVATIVES OF PENTAPEPTIDES AND TETRAPEPTIDES AND THEIR USE AS MEDICINAL PRODUCTS
EP0002236A1 (en) * 1977-11-24 1979-06-13 The Wellcome Foundation Limited Peptides, their salts, their acid addition salts, pharmaceutical formulations containing them and their use as morphine antagonists and anaesthetics
EP0008196A1 (en) * 1978-08-08 1980-02-20 American Home Products Corporation Pentapeptides, processes for their preparation, intermediates used in such processes, use in pharmaceutical compositions and compositions containing them
FR2465713A1 (en) * 1979-09-20 1981-03-27 Erba Farmitalia NOVEL BIOLOGICALLY ACTIVE PEPTIDES AND THEIR USE AS MEDICAMENTS

Also Published As

Publication number Publication date
PT66982B (en) 1979-02-13
DK386677A (en) 1978-03-02
NL7709653A (en) 1978-03-03
ZA775285B (en) 1978-07-26
SE7709806L (en) 1978-03-02
FR2381746A1 (en) 1978-09-22
BE858344A (en) 1978-01-02
AU2844577A (en) 1979-03-08
ES462221A1 (en) 1979-10-01
NO773013L (en) 1978-03-02
PL200605A1 (en) 1979-02-12
FR2364889B1 (en) 1981-06-19
DE2739440A1 (en) 1978-03-02
JPS5356634A (en) 1978-05-23
IL52870A0 (en) 1977-11-30
PT66982A (en) 1977-09-01
YU208677A (en) 1982-08-31

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Legal Events

Date Code Title Description
ST Notification of lapse
AR Application made for restoration
BR Restoration of rights
ST Notification of lapse