GB2010280A - Somatostatin analogs - Google Patents
Somatostatin analogsInfo
- Publication number
- GB2010280A GB2010280A GB7839504A GB7839504A GB2010280A GB 2010280 A GB2010280 A GB 2010280A GB 7839504 A GB7839504 A GB 7839504A GB 7839504 A GB7839504 A GB 7839504A GB 2010280 A GB2010280 A GB 2010280A
- Authority
- GB
- United Kingdom
- Prior art keywords
- gly
- phe
- ala
- cys
- trp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Somatostatin analogs of the formula (I) X<1>-Cys(SA)-X<2>-X<3>-Phe-Phe- D-Trp-Lys-Thr-Phe-Thr-Ser-Cys(SA)-OH wherein A is hydrogen, or the A groups represent a direct bond between the sulphur atoms; X<1> is hydrogen, H-Gly, H-Ala-Gly, H- Ala-Ala or H-Gly-Gly-Gly; X<2> and X<3> are independently Gly, D- Leu, D-Phe, D-Tyr, D-Trp, D-Met, D-His, D-Arg, D-Lys, D-Ser, D-Asp, or D-Asn; provided that X<2> and X<3> are not simultaneously Gly; and the pharmacologically-acceptable salts thereof. Compounds (I), which inhibit the release of pituary growth hormone, glucagen and insulin, may be admixed with a pharmaceutically acceptable carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/860,279 US4122077A (en) | 1976-12-17 | 1977-12-13 | Somatostatin analogs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB2010280A true GB2010280A (en) | 1979-06-27 |
| GB2010280B GB2010280B (en) | 1982-04-21 |
Family
ID=25332860
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB7839504A Expired GB2010280B (en) | 1977-12-13 | 1978-10-05 | Somatostatin analogues |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS5484573A (en) |
| BE (1) | BE871051A (en) |
| CH (1) | CH634550A5 (en) |
| DE (1) | DE2843737A1 (en) |
| DK (1) | DK432878A (en) |
| FR (1) | FR2411827A1 (en) |
| GB (1) | GB2010280B (en) |
| IT (1) | IT1099705B (en) |
| LU (1) | LU80335A1 (en) |
| NL (1) | NL7810197A (en) |
| SE (1) | SE7810156L (en) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4061608A (en) * | 1976-07-13 | 1977-12-06 | American Home Products Corporation | Arg 4 -somatostatin and analogues thereof |
| US4081433A (en) * | 1977-01-13 | 1978-03-28 | American Home Products Corporation | D-Nle4 -somatostatin and analogues thereof |
| IE46462B1 (en) * | 1977-02-22 | 1983-06-15 | American Home Prod | Somatostatin peptide analogues |
-
1978
- 1978-09-27 SE SE7810156A patent/SE7810156L/en unknown
- 1978-09-29 DK DK432878A patent/DK432878A/en not_active Application Discontinuation
- 1978-10-05 BE BE190944A patent/BE871051A/en not_active IP Right Cessation
- 1978-10-05 GB GB7839504A patent/GB2010280B/en not_active Expired
- 1978-10-06 LU LU80335A patent/LU80335A1/en unknown
- 1978-10-06 DE DE19782843737 patent/DE2843737A1/en not_active Withdrawn
- 1978-10-10 NL NL7810197A patent/NL7810197A/en not_active Application Discontinuation
- 1978-10-10 CH CH1052778A patent/CH634550A5/en not_active IP Right Cessation
- 1978-10-12 IT IT28705/78A patent/IT1099705B/en active
- 1978-10-13 FR FR7829260A patent/FR2411827A1/en active Granted
- 1978-10-17 JP JP12829678A patent/JPS5484573A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| FR2411827A1 (en) | 1979-07-13 |
| SE7810156L (en) | 1979-06-14 |
| IT7828705A0 (en) | 1978-10-12 |
| JPS5484573A (en) | 1979-07-05 |
| FR2411827B1 (en) | 1983-12-09 |
| CH634550A5 (en) | 1983-02-15 |
| GB2010280B (en) | 1982-04-21 |
| BE871051A (en) | 1979-04-05 |
| NL7810197A (en) | 1979-06-15 |
| DE2843737A1 (en) | 1979-06-28 |
| IT1099705B (en) | 1985-09-28 |
| DK432878A (en) | 1979-06-14 |
| LU80335A1 (en) | 1979-03-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PCNP | Patent ceased through non-payment of renewal fee |