JPS5645450A - Pentapeptide compound - Google Patents

Pentapeptide compound

Info

Publication number
JPS5645450A
JPS5645450A JP12165479A JP12165479A JPS5645450A JP S5645450 A JPS5645450 A JP S5645450A JP 12165479 A JP12165479 A JP 12165479A JP 12165479 A JP12165479 A JP 12165479A JP S5645450 A JPS5645450 A JP S5645450A
Authority
JP
Japan
Prior art keywords
met
pentapeptide
condensation
morphinelike
tyn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP12165479A
Other languages
Japanese (ja)
Inventor
Hiroshi Takagi
Haruaki Yajima
Osamu Nagase
Minoru Kubota
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Priority to JP12165479A priority Critical patent/JPS5645450A/en
Publication of JPS5645450A publication Critical patent/JPS5645450A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

NEW MATERIAL:A pentapeptide expressed by the formula (Y is Met or Leu; Z is OH or NH2.
EXAMPLE: H-Tyn-D-Arg-Gly-Phe-Met-NH2.
USE: An analgesic agent having a morphinelike action with lower toxicity than the morphine.
PROCESS: Synthesized by the conventional liquid or solid phase method. The peptide chain is extended by the condensation methods, e.g. the stepwise elongation or fragment condensation method utilizing the azide, mixed acid anhydride or DCC method in a solvent, e.g. dimethylformamide. The final removal of the protecting group is carried out by the catalytic reduction or with hydrogen fluoride or acetic acid used generally in the field of peptides, and the purification by an ion exchange resin or partition chromatography.
COPYRIGHT: (C)1981,JPO&Japio
JP12165479A 1979-09-21 1979-09-21 Pentapeptide compound Pending JPS5645450A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12165479A JPS5645450A (en) 1979-09-21 1979-09-21 Pentapeptide compound

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12165479A JPS5645450A (en) 1979-09-21 1979-09-21 Pentapeptide compound

Publications (1)

Publication Number Publication Date
JPS5645450A true JPS5645450A (en) 1981-04-25

Family

ID=14816590

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12165479A Pending JPS5645450A (en) 1979-09-21 1979-09-21 Pentapeptide compound

Country Status (1)

Country Link
JP (1) JPS5645450A (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5356634A (en) * 1976-09-01 1978-05-23 Coy David Howard Pharmaceutical composition

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5356634A (en) * 1976-09-01 1978-05-23 Coy David Howard Pharmaceutical composition

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