RU94024278A - PEPTIDE AND METHOD FOR ITS PREPARATION - Google Patents

PEPTIDE AND METHOD FOR ITS PREPARATION

Info

Publication number
RU94024278A
RU94024278A RU94024278/14A RU94024278A RU94024278A RU 94024278 A RU94024278 A RU 94024278A RU 94024278/14 A RU94024278/14 A RU 94024278/14A RU 94024278 A RU94024278 A RU 94024278A RU 94024278 A RU94024278 A RU 94024278A
Authority
RU
Russia
Prior art keywords
cys
ala
orn
lys
tyr
Prior art date
Application number
RU94024278/14A
Other languages
Russian (ru)
Other versions
RU2067000C1 (en
Inventor
В.И. Дейгин
Е.П. Ярова
Original Assignee
Инженерный центр пептидных препаратов "Пептос"
Filing date
Publication date
Application filed by Инженерный центр пептидных препаратов "Пептос" filed Critical Инженерный центр пептидных препаратов "Пептос"
Priority claimed from RU9494024278A external-priority patent/RU2067000C1/en
Priority to RU9494024278A priority Critical patent/RU2067000C1/en
Priority to PT95924554T priority patent/PT779076E/en
Priority to AT95924554T priority patent/ATE290547T1/en
Priority to DE69534061T priority patent/DE69534061T2/en
Priority to ES95924554T priority patent/ES2239760T3/en
Priority to DK95924554T priority patent/DK0779076T3/en
Priority to CNB951943820A priority patent/CN1165336C/en
Priority to PCT/RU1995/000138 priority patent/WO1996002267A1/en
Priority to JP50356096A priority patent/JP3668950B2/en
Priority to AU29002/95A priority patent/AU693576B2/en
Priority to CA2193969A priority patent/CA2193969C/en
Priority to EP95924554A priority patent/EP0779076B1/en
Priority to US08/681,248 priority patent/US6184208B1/en
Publication of RU2067000C1 publication Critical patent/RU2067000C1/en
Application granted granted Critical
Publication of RU94024278A publication Critical patent/RU94024278A/en
Priority to HK98113808A priority patent/HK1012551A1/en

Links

Claims (2)

1. Пептид формулы
X-Tyr-Y-Phe-Z-A,
где X - H или Arg, D-Arg, Orn, D-Orn, Lys, D-Lys, -Har, D-Har, Cyt, D-Cyt.1. The peptide of the formula
X-Tyr-Y-Phe-ZA,
where X is H or Arg, D-Arg, Orn, D-Orn, Lys, D-Lys, -Har, D-Har, Cyt, D-Cyt. Y - D-Ala, D-Val, D-Ltu, D-Ile, D-Phe, D-Asn, D-Trp, D-Pro, D-Ser, D-Thr, D-Tyr, D-Hyr, D-Cys, D-Cys-Cys, D-Met, D-Lys, D-Ags, D-His, D-Asp, D-Glu, D-Ala, D-Orn. Y — D-Ala, D-Val, D-Ltu, D-Ile, D-Phe, D-Asn, D-Trp, D-Pro, D-Ser, D-Thr, D-Tyr, D-Hyr, D-Cys, D-Cys-Cys, D-Met, D-Lys, D-Ags, D-His, D-Asp, D-Glu, D-Ala, D-Orn. Z - оптически активная аминокислота: Ala, D-Ala, Val,-Val, Leu, D-Leu, Ile, D-Ile, Phe, D-Phe, Asn, D-Asn, Gln, D-Gln, Trp, D-Trp, Pro, D-Pro, Ser, D-Ser, Thr, D-Thr, Tyr, D-Tyr, Hyp, D-Hyp, Cys, D-Cys, Cys-Cys, Cys-D-Cys, D-Cys-Cys, D-Cys-D-Cys, Met, D-Met, Lys, D-Lys, Arg, D-Arg, His, D-His, Asp, D-Asp, Glu, D-Glu, B-Ala, D-B-Ala, Orn, D-Orn, Gly. Z - optically active amino acids: Ala, D-Ala, Val, -Val, Leu, D-Leu, Ile, D-Ile, Phe, D-Phe, Asn, D-Asn, Gln, D-Gln, Trp, D -Trp, Pro, D-Pro, Ser, D-Ser, Thr, D-Thr, Tyr, D-Tyr, Hyp, D-Hyp, Cys, D-Cys, Cys-Cys, Cys-D-Cys, D -Cys-Cys, D-Cys-D-Cys, Met, D-Met, Lys, D-Lys, Arg, D-Arg, His, D-His, Asp, D-Asp, Glu, D-Glu, B -Ala, DB-Ala, Orn, D-Orn, Gly. А - ОН или замещенный амид (С1 - С3).And - HE or substituted amide (C 1 - C 3 ). 2. Способ получения пептида формулы
X - Tyr - Y - Phe - Z - A,
где Х - Н или Arg, D-Arg, Orn, D-Orn, Lys, D-Lys, -Har, D-Har, Cyt, D-Cyt.2. The method of obtaining the peptide of the formula
X - Tyr - Y - Phe - Z - A,
where X is H or Arg, D-Arg, Orn, D-Orn, Lys, D-Lys, -Har, D-Har, Cyt, D-Cyt. Y - D-Ala, D-Val, D-Ltu, D-Ile, D-Phe, D-Asn, D-Trp, D-Pro, D-Ser, D-Thr, D-Tyr, D-Hyp, D-Cys, D-Cys-Cys, D-Met, D-Lys, D-Ags, D-His, D-Asp, D-Glu, D-Ala, D-Orn. Y — D-Ala, D-Val, D-Ltu, D-Ile, D-Phe, D-Asn, D-Trp, D-Pro, D-Ser, D-Thr, D-Tyr, D-Hyp, D-Cys, D-Cys-Cys, D-Met, D-Lys, D-Ags, D-His, D-Asp, D-Glu, D-Ala, D-Orn. Z - оптически активная аминокислота: Ala, D-Ala, Val,-Val, Leu, D-Leu, Ile, D-Ile, Phe, D-Phe, Asn, D-Asn, Gln, D-Gln, Trp, D-Trp, Pro, D-Pro, Ser, D-Ser, Thrp, D-Thr, Tyr, D-Tyr, Hyr, D-Hyp, Cys, D-Cys, Cys-Cys, Cys-D-Cys, D-Cys-Cys, D-Cys-D-Cys, Met, D-Met, Lys, D-Lys, Arg, D-Arg, His, D-His, Asp, D-Asp, Glu, D-Glu, B-Ala, D-B-Ala, Orn, D-Orn, Gly. Z - optically active amino acids: Ala, D-Ala, Val, -Val, Leu, D-Leu, Ile, D-Ile, Phe, D-Phe, Asn, D-Asn, Gln, D-Gln, Trp, D - Trp, Pro, D-Pro, Ser, D-Ser, Thrp, D-Thr, Tyr, D-Tyr, Hyr, D-Hyp, Cys, D-Cys, Cys-Cys, Cys-D-Cys, D -Cys-Cys, D-Cys-D-Cys, Met, D-Met, Lys, D-Lys, Arg, D-Arg, His, D-His, Asp, D-Asp, Glu, D-Glu, B -Ala, DB-Ala, Orn, D-Orn, Gly. A - OH или замещенный амид (С1 - С3),
заключающийся в том, что процесс ведут в растворе, используя метод смешанных ангидридов, где в качестве исходного используют бензиловый эфир аминокислоты и третбутилоксикарбонилфенилаланин, к полученному соединению последовательно присоединяют третбутилоксикарбониламинокислоты с предварительным отщеплением на каждой стадии третбутилоксикарбонильной группы в кислой среде, затем пропускают ток водорода в присутствии палладиевого катализатора и целевой продукт очищают ионообменной хроматографией.A - OH or substituted amide (C 1 - C 3 ),
consisting in that the process is carried out in solution, using the method of mixed anhydrides, where the initial use benzyl ester amino acid and tretbutiloksikarbonilfenilalanin, the resulting compound successively attached tretbutiloksikarbonilaminokisloty with prior cleavage at each stage tretbutiloksikarbonilnoy group in acidic medium, then passed hydrogen current in the presence of palladium catalyst and target product are purified by ion exchange chromatography.
RU9494024278A 1994-06-29 1994-06-29 Peptide and a method of its synthesis RU2067000C1 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
RU9494024278A RU2067000C1 (en) 1994-06-29 1994-06-29 Peptide and a method of its synthesis
CNB951943820A CN1165336C (en) 1994-06-29 1995-06-27 Peptide, a method of obtaining it and a pharmaceutical compound based on it
JP50356096A JP3668950B2 (en) 1994-06-29 1995-06-27 Peptides, their synthesis methods and pharmaceuticals based on them
DE69534061T DE69534061T2 (en) 1994-06-29 1995-06-27 A PEPTIDE, A METHOD OF ITS PRESENTATION AND A PHARMACEUTICAL PREPARATION BASED ON HIM
ES95924554T ES2239760T3 (en) 1994-06-29 1995-06-27 PEPTIDE, A METHOD TO OBTAIN IT AND A PHARMACEUTICAL COMPOSITION BASED ON IT.
DK95924554T DK0779076T3 (en) 1994-06-29 1995-06-27 Peptide, a method of preparing it and a pharmaceutical compound based on it
PT95924554T PT779076E (en) 1994-06-29 1995-06-27 A METHOD FOR THEIR OBTAINATION AND A PHARMACEUTICAL COMPOSITION OM BASED ON THESE
PCT/RU1995/000138 WO1996002267A1 (en) 1994-06-29 1995-06-27 Peptide, a method of obtaining it and a pharmaceutical compound based on it
AT95924554T ATE290547T1 (en) 1994-06-29 1995-06-27 A PEPTIDE, A METHOD FOR THE PREPARATION THEREOF AND A PHARMACEUTICAL PREPARATION BASED THEREOF
AU29002/95A AU693576B2 (en) 1994-06-29 1995-06-27 Peptide, a method of obtaining it and a pharmaceutical compound based on it
CA2193969A CA2193969C (en) 1994-06-29 1995-06-27 Peptide, a method of obtaining it and a pharmaceutical compound based on it
EP95924554A EP0779076B1 (en) 1994-06-29 1995-06-27 Peptide, a method of obtaining it and a pharmaceutical compound based on it
US08/681,248 US6184208B1 (en) 1994-06-29 1996-07-22 Peptide, a method for its preparation and a pharmaceutical composition containing the peptide
HK98113808A HK1012551A1 (en) 1994-06-29 1998-12-17 Peptide, a method of obtaining it and a pharmaceutical compound based on it.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU9494024278A RU2067000C1 (en) 1994-06-29 1994-06-29 Peptide and a method of its synthesis

Publications (2)

Publication Number Publication Date
RU2067000C1 RU2067000C1 (en) 1996-09-27
RU94024278A true RU94024278A (en) 1997-11-10

Family

ID=20157803

Family Applications (1)

Application Number Title Priority Date Filing Date
RU9494024278A RU2067000C1 (en) 1994-06-29 1994-06-29 Peptide and a method of its synthesis

Country Status (13)

Country Link
EP (1) EP0779076B1 (en)
JP (1) JP3668950B2 (en)
CN (1) CN1165336C (en)
AT (1) ATE290547T1 (en)
AU (1) AU693576B2 (en)
CA (1) CA2193969C (en)
DE (1) DE69534061T2 (en)
DK (1) DK0779076T3 (en)
ES (1) ES2239760T3 (en)
HK (1) HK1012551A1 (en)
PT (1) PT779076E (en)
RU (1) RU2067000C1 (en)
WO (1) WO1996002267A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5868728A (en) * 1995-02-28 1999-02-09 Photogenesis, Inc. Medical linear actuator for surgical delivery, manipulation, and extraction
RU2107691C1 (en) * 1995-03-02 1998-03-27 Дейгин Владислав Исакович Peptide and method for its preparation
US6127339A (en) * 1995-06-21 2000-10-03 Asahi Kasei Kogyo Kabushiki Kaisha Peptide for binding thereto a low density lipoprotein
WO1997010261A1 (en) * 1995-09-11 1997-03-20 Daiichi Pharmaceutical Co., Ltd. Peptide derivatives
WO2000043352A1 (en) 1999-01-22 2000-07-27 Pharmacore, Inc. A method for the synthesis of compounds of formula 1 and derivatives thereof
US7473426B2 (en) 2001-02-27 2009-01-06 Yun Seok Choe Method for selectively inhibiting reuptake of serotonin and norepinephrine using yeast extract
WO2002067959A1 (en) * 2001-02-27 2002-09-06 Neurotide Co., Ltd. Peptide derived from yeast having activities as anti-tsress, anti-fatigue and brain neurotrophic factor and relaxing premenstrual syndrome and menstrual pain, and prepairing process thereof
CN101627049B (en) 2006-11-10 2012-09-05 卡拉治疗学股份有限公司 Synthetic peptide amides
US7842662B2 (en) 2006-11-10 2010-11-30 Cara Therapeutics, Inc. Synthetic peptide amide dimers
US8236766B2 (en) 2006-11-10 2012-08-07 Cara Therapeutics, Inc. Uses of synthetic peptide amides
US8906859B2 (en) 2006-11-10 2014-12-09 Cera Therapeutics, Inc. Uses of kappa opioid synthetic peptide amides
US7713937B2 (en) 2006-11-10 2010-05-11 Cara Therapeutics, Inc. Synthetic peptide amides and dimeric forms thereof
US10221213B2 (en) 2013-12-27 2019-03-05 Stealth Biotherapeutics Corp Pharmaceutically relevant aromatic-cationic peptides
CA2978905A1 (en) 2015-03-06 2016-09-15 Stealth Biotherapeutics Corp Processes for preparing pharmaceutically relevant peptides
KR102429287B1 (en) * 2015-12-10 2022-08-05 가부시끼가이샤 메니콘 Peptide composition

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8005121A (en) * 1979-09-20 1981-03-24 Erba Farmitalia ORGANICALLY ACTIVE PEPTIDES.
IE56021B1 (en) * 1982-10-13 1991-03-27 Akzo Nv Peptides
JPS59181293A (en) * 1983-03-31 1984-10-15 Kyowa Hakko Kogyo Co Ltd Novel physiologically active proteinous substance
FR2546756B1 (en) * 1983-06-03 1985-11-29 Centre Nat Rech Scient NOVEL IMMUNOSTIMULATING DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS
GB2146026A (en) * 1983-09-07 1985-04-11 Tanabe Seiyaku Co Peptides and process for preparing the same
DE3435727A1 (en) * 1984-09-28 1986-04-10 Victor Dipl.-Chem. Dr.med. 6200 Wiesbaden Brantl PHARMACOLOGICALLY ACTIVE PEPTIDES
DE3841763A1 (en) * 1988-12-12 1990-06-13 Basf Ag NEW TNF PEPTIDES
DE3841761A1 (en) * 1988-12-12 1990-06-13 Basf Ag NEW TNF PEPTIDES
SE9300012D0 (en) * 1993-01-05 1993-01-05 Astra Ab NEW PEPTIDES

Similar Documents

Publication Publication Date Title
RU94024278A (en) PEPTIDE AND METHOD FOR ITS PREPARATION
Coy et al. Synthesis and opioid activities of stereoisomers and other D-amino acid analogs of methionine-enkephalin
US4707468A (en) Polypeptide
FI91075B (en) Process for the preparation of novel therapeutically useful peptides
Amiche et al. Dermenkephalin (Tyr-D-Met-Phe-His-Leu-Met-Asp-NH2): a potent and fully specific agonist for the delta opioid receptor.
WO1999021571A1 (en) Melanocortin receptor ligands and methods of using same
HUE026698T2 (en) Peptide fragments for inducing synthesis of extracellular matrix proteins
RU95108559A (en) PEPTID AND METHOD FOR ITS PRODUCTION
US4649191A (en) Conformationally constrained alpha-melanotropin analogs with specific central nervous system activity
CA2193969A1 (en) Peptide, a method of obtaining it and a pharmaceutical compound based on it
UA48974C2 (en) Peptide and method of its production
Sawyer et al. α-Melanocyte stimulating hormone message and inhibitory sequences: comparative structure-activity studies on melanocytes
Schmitt et al. Total synthesis of the α‐helical eicosapeptide antibiotic alamethicin
DE19911771A1 (en) New LHRH antagonists with improved solubility properties
WO2006064530A2 (en) Dermorphin analogs with analgesic activity
US4652627A (en) Calcitonin analogs with C-terminal D-amino acid substituents
EP0341603A3 (en) Atrial peptide derivatives
YAMASHIRO et al. Synthesis and properties of dermorphin and an analog of β‐endorphin containing the dermorphin sequence
EP0189326A3 (en) Derivatives of arginine vasopressin antagonists
RU2006111491A (en) NEW TUMOR COMPOUNDS
NZ193435A (en) Peptides having thymopoietin-like activity
EP0151016A3 (en) Arginine vasopressin antagonists
ES536117A0 (en) A PROCEDURE FOR PREPARING CYCLICAL HEPTAPEPTIDES AND HEXAPEPTIDES FOR VASOPRESSIN ANTAGONISTS
EP0138604A3 (en) Arginine vasopressin antagonists
CHEESMAN et al. Anovulatory effect of synthetic analogs of arginine vasotocin in the rat