ES462221A1 - Pharmaceutical composition - Google Patents

Pharmaceutical composition

Info

Publication number
ES462221A1
ES462221A1 ES462221A ES462221A ES462221A1 ES 462221 A1 ES462221 A1 ES 462221A1 ES 462221 A ES462221 A ES 462221A ES 462221 A ES462221 A ES 462221A ES 462221 A1 ES462221 A1 ES 462221A1
Authority
ES
Spain
Prior art keywords
tyr
phe
gly
met
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES462221A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KASTIN ABBA JEREM
Original Assignee
KASTIN ABBA JEREM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KASTIN ABBA JEREM filed Critical KASTIN ABBA JEREM
Publication of ES462221A1 publication Critical patent/ES462221A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/70—Enkephalins
    • C07K14/702—Enkephalins with at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Pentapeptides of formula (I) and their salts are new: H-Tyr-X-Gly-Phe-Met-Y (I), (where X is D-Ala, D-Leu, D-Ile, D-Val, D-Phe, D-Tyr, D-Trp, D-Ser, D-Thr, D-Met, D-Glu, D-Gln, D-Asp, D-Asn, D-Lys or D-Arg Y is NH2 or OH). (I) are analogues of methionine encephalin (H-Tyr-Gly-Gly-Phe-Met-OH) with analgesic and antidepressant activity- Cpd. (I) X = D-Ala, Y = OH) is stated to be a considerably more powerful analgesic than morphine.
ES462221A 1976-09-01 1977-09-01 Pharmaceutical composition Expired ES462221A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71939776A 1976-09-01 1976-09-01

Publications (1)

Publication Number Publication Date
ES462221A1 true ES462221A1 (en) 1979-10-01

Family

ID=24889909

Family Applications (1)

Application Number Title Priority Date Filing Date
ES462221A Expired ES462221A1 (en) 1976-09-01 1977-09-01 Pharmaceutical composition

Country Status (15)

Country Link
JP (1) JPS5356634A (en)
AU (1) AU2844577A (en)
BE (1) BE858344A (en)
DE (1) DE2739440A1 (en)
DK (1) DK386677A (en)
ES (1) ES462221A1 (en)
FR (2) FR2364889A1 (en)
IL (1) IL52870A0 (en)
NL (1) NL7709653A (en)
NO (1) NO773013L (en)
PL (1) PL200605A1 (en)
PT (1) PT66982B (en)
SE (1) SE7709806L (en)
YU (1) YU208677A (en)
ZA (1) ZA775285B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2359817A1 (en) * 1976-07-27 1978-02-24 Reckitt & Colmann Prod Ltd Peptide cpds. contg. tyrosine, glycine, phenylalanine and d-amino acid - local anaesthetics, smooth muscle relaxants, adrenergic neutron blockers, beta-stimulants etc.
US4259234A (en) * 1976-09-27 1981-03-31 Eli Lilly And Company Analgesic compounds
GB1604850A (en) * 1977-11-24 1981-12-16 Wellcome Found Biologically active peptides
US4278596A (en) * 1978-08-08 1981-07-14 American Home Products Corporation Analgesic pentapeptides
CA1175810A (en) * 1979-03-30 1984-10-09 Frank A. Momany Synthetic peptides having pituitary growth hormone releasing activity
DE2933947A1 (en) * 1979-08-22 1981-03-12 Hoechst Ag, 6000 Frankfurt NEW PEPTIDAMIDES AND METHOD FOR THEIR PRODUCTION.
NL8005121A (en) * 1979-09-20 1981-03-24 Erba Farmitalia ORGANICALLY ACTIVE PEPTIDES.
JPS5645450A (en) * 1979-09-21 1981-04-25 Dai Ichi Seiyaku Co Ltd Pentapeptide compound
DE2941790A1 (en) * 1979-10-16 1981-04-30 Hoechst Ag, 6000 Frankfurt USE OF MOTIVITY-INCREASING PEPTIDES

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1532181A (en) * 1976-02-02 1978-11-15 Beckman Instruments Inc Pentapetides and a method of preparing them
NZ183712A (en) * 1976-04-08 1979-10-25 Ici Ltd Polypeptide analogues of enkephalins, and pharmaceutical compositions
US4259234A (en) * 1976-09-27 1981-03-31 Eli Lilly And Company Analgesic compounds

Also Published As

Publication number Publication date
FR2381746A1 (en) 1978-09-22
PL200605A1 (en) 1979-02-12
FR2364889A1 (en) 1978-04-14
BE858344A (en) 1978-01-02
JPS5356634A (en) 1978-05-23
NO773013L (en) 1978-03-02
DE2739440A1 (en) 1978-03-02
PT66982A (en) 1977-09-01
FR2364889B1 (en) 1981-06-19
PT66982B (en) 1979-02-13
AU2844577A (en) 1979-03-08
DK386677A (en) 1978-03-02
SE7709806L (en) 1978-03-02
NL7709653A (en) 1978-03-03
ZA775285B (en) 1978-07-26
IL52870A0 (en) 1977-11-30
YU208677A (en) 1982-08-31

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