FR2362158A1 - Nouveaux 5,6-dihydro-syn(1)triazine nucleosides et nucleotides, leur procede de preparation et medicament les contenant - Google Patents
Nouveaux 5,6-dihydro-syn(1)triazine nucleosides et nucleotides, leur procede de preparation et medicament les contenantInfo
- Publication number
- FR2362158A1 FR2362158A1 FR7725483A FR7725483A FR2362158A1 FR 2362158 A1 FR2362158 A1 FR 2362158A1 FR 7725483 A FR7725483 A FR 7725483A FR 7725483 A FR7725483 A FR 7725483A FR 2362158 A1 FR2362158 A1 FR 2362158A1
- Authority
- FR
- France
- Prior art keywords
- dihydro
- syn
- nucleotides
- new
- preparation process
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical compound C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 239000002777 nucleoside Substances 0.000 title 1
- 239000002773 nucleotide Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/10—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
- C07D251/20—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with no nitrogen atoms directly attached to a ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/12—Triazine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne de nouvelles 1-(2-déoxy- beta -D-pentofuranosyl)-5,6-dihydro-s-triazines. Ces composés sont préparés par réaction d'un halogénure de 3',5'-di-o-(groupe protecteur)-2-déoxypento-furanosyle, par exemple à groupe protecteur acyle, avec une base 5,6-dihydro-s-triazinique. Les composés de l'invention sont doués de propriétés antivirales.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71566476A | 1976-08-19 | 1976-08-19 | |
US05/802,555 US4171431A (en) | 1976-08-19 | 1977-06-01 | Nucleosides and process |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2362158A1 true FR2362158A1 (fr) | 1978-03-17 |
FR2362158B1 FR2362158B1 (fr) | 1980-07-11 |
Family
ID=27109394
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7725483A Granted FR2362158A1 (fr) | 1976-08-19 | 1977-08-19 | Nouveaux 5,6-dihydro-syn(1)triazine nucleosides et nucleotides, leur procede de preparation et medicament les contenant |
Country Status (6)
Country | Link |
---|---|
US (1) | US4171431A (fr) |
JP (1) | JPS5325583A (fr) |
DE (1) | DE2735378A1 (fr) |
FR (1) | FR2362158A1 (fr) |
GB (1) | GB1553475A (fr) |
NL (1) | NL7709010A (fr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS52107985A (en) * | 1976-02-26 | 1977-09-10 | Toshitaka Fujii | Reinforced fishing rods and process for producing same |
US4477442A (en) * | 1978-12-12 | 1984-10-16 | The Upjohn Company | Composition of matter and process |
US4508898A (en) * | 1980-09-16 | 1985-04-02 | Ogilvie Kelvin K | Antiviral triazine compounds |
US4501744A (en) * | 1980-09-16 | 1985-02-26 | Ens Bio Logicals Inc. | Substituted-aza-cytosine compounds and anti-viral uses thereof |
US4868187A (en) * | 1980-09-16 | 1989-09-19 | Syntex (U.S.A.) Inc. | Anti-viral N-substituted pyrimidines |
US4689321A (en) * | 1984-07-20 | 1987-08-25 | The Research Foundation Of State University Of New York | Oxo propenyl nucleosides and nucleoside related analogs |
JPS6212790A (ja) * | 1985-07-09 | 1987-01-21 | Teijin Ltd | 3,5−ジアシル−2−デオキシリボフラノシルハライド類の製法 |
JPS6359664U (fr) * | 1986-10-09 | 1988-04-20 | ||
US20070207973A1 (en) * | 2002-09-24 | 2007-09-06 | Koronis Pharmaceuticals, Incorporated | 1,3,5-Triazines for Treatment of Viral Diseases |
CA2499036A1 (fr) * | 2002-09-24 | 2004-04-08 | Koronis Pharmaceuticals, Incorporated | 1, 3, 5-triazines destinees au traitement de maladies virales |
US7244732B2 (en) * | 2003-06-20 | 2007-07-17 | Koronis Pharmaceuticals, Incorporated | Prodrugs of heteroaryl compounds |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8907779B1 (en) * | 2011-02-28 | 2014-12-09 | Sandra Ross | Alerting device and associated method |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1795357A1 (de) * | 1968-09-18 | 1972-01-05 | Schering Ag | 2-Thio-pyrimidin-nucleoside |
CH541566A (de) * | 1969-04-11 | 1973-09-15 | Schering Ag | Verfahren zur Herstellung von Nucleosiden |
US3721664A (en) * | 1970-01-27 | 1973-03-20 | Hoffmann La Roche | Preparation of 5-cytosine nucleosides |
DE2012888C3 (de) * | 1970-03-14 | 1981-04-02 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von 5-Azapyrimidinnucleosiden |
US3907779A (en) * | 1974-05-20 | 1975-09-23 | Upjohn Co | 5,6 Dihydro-5-azathymidine and derivatives |
-
1977
- 1977-06-01 US US05/802,555 patent/US4171431A/en not_active Expired - Lifetime
- 1977-08-04 GB GB32710/77A patent/GB1553475A/en not_active Expired
- 1977-08-05 DE DE19772735378 patent/DE2735378A1/de active Granted
- 1977-08-16 NL NL7709010A patent/NL7709010A/xx not_active Application Discontinuation
- 1977-08-19 JP JP9942977A patent/JPS5325583A/ja active Granted
- 1977-08-19 FR FR7725483A patent/FR2362158A1/fr active Granted
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8907779B1 (en) * | 2011-02-28 | 2014-12-09 | Sandra Ross | Alerting device and associated method |
Also Published As
Publication number | Publication date |
---|---|
DE2735378A1 (de) | 1978-02-23 |
DE2735378C2 (fr) | 1989-05-11 |
NL7709010A (nl) | 1978-02-21 |
JPS5325583A (en) | 1978-03-09 |
FR2362158B1 (fr) | 1980-07-11 |
GB1553475A (en) | 1979-09-26 |
JPS6133038B2 (fr) | 1986-07-31 |
US4171431A (en) | 1979-10-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |