FR2361867A1 - Emulsion de fluorocarbure pouvant transporter de l'oxygene - Google Patents

Emulsion de fluorocarbure pouvant transporter de l'oxygene

Info

Publication number
FR2361867A1
FR2361867A1 FR7620907A FR7620907A FR2361867A1 FR 2361867 A1 FR2361867 A1 FR 2361867A1 FR 7620907 A FR7620907 A FR 7620907A FR 7620907 A FR7620907 A FR 7620907A FR 2361867 A1 FR2361867 A1 FR 2361867A1
Authority
FR
France
Prior art keywords
fluorocarbide
emulsion capable
carrying oxygen
emulsion
weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7620907A
Other languages
English (en)
Other versions
FR2361867B1 (fr
Inventor
Kazumasa Yokoyama
Kouichi Yamanouchi
Ryoichiro Murashima
Yoshio Tsuda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Green Cross Corp Japan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Green Cross Corp Japan filed Critical Green Cross Corp Japan
Publication of FR2361867A1 publication Critical patent/FR2361867A1/fr
Application granted granted Critical
Publication of FR2361867B1 publication Critical patent/FR2361867B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Une émulsion de perfluorocarbure capable de transporter de l'oxygène. Elle se prépare en émulsionnant en milieu aqueux 50 à 95 parties en poids d'un perfluorocarbure comme la perfluorodécaline, et 50 à 5 parties en poids d'une perfluoro tert-amine, par exemple une perfluoro tert-alkylamine en C9 à C11 , au moyen d'un agent tensio-actif non ionique d'une masse moléculaire d'environ 2000 à 20000, des phospholipides comme agent émulsionnant, et des acides gras en C8 à C22 comme adjuvants de l'émulsionnant. L'émulsion est utilisée comme substitut du sang.
FR7620907A 1976-02-03 1976-07-08 Emulsion de fluorocarbure pouvant transporter de l'oxygene Granted FR2361867A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65496476A 1976-02-03 1976-02-03

Publications (2)

Publication Number Publication Date
FR2361867A1 true FR2361867A1 (fr) 1978-03-17
FR2361867B1 FR2361867B1 (fr) 1978-12-15

Family

ID=24626936

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7620907A Granted FR2361867A1 (fr) 1976-02-03 1976-07-08 Emulsion de fluorocarbure pouvant transporter de l'oxygene

Country Status (22)

Country Link
JP (1) JPS5835485B2 (fr)
AR (1) AR218864A1 (fr)
AT (1) AT355214B (fr)
BE (1) BE850992A (fr)
CA (1) CA1072446A (fr)
CH (1) CH633674A5 (fr)
DD (1) DD132231A5 (fr)
DE (1) DE2630586C2 (fr)
DK (1) DK152256C (fr)
ES (1) ES449635A1 (fr)
FI (1) FI58071C (fr)
FR (1) FR2361867A1 (fr)
GB (1) GB1549038A (fr)
IL (1) IL51325A (fr)
LU (1) LU76698A1 (fr)
MX (1) MX4136E (fr)
NL (1) NL171533C (fr)
NO (1) NO145370C (fr)
NZ (1) NZ183096A (fr)
SE (1) SE442706B (fr)
SU (1) SU797546A3 (fr)
ZA (1) ZA77229B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2447195A1 (fr) * 1979-01-25 1980-08-22 Wada Juro Composition de contraste pour angiographie

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4186253A (en) * 1978-10-10 1980-01-29 The Green Cross Corporation Perfusate for preserving organ to be transplanted and preserving method
EP0077114B1 (fr) * 1981-09-08 1987-12-02 Green Cross Corporation Produits perfluorochimiques, procédé de leur préparation et leur utilisation à titre de succédané du sang
US4423077A (en) * 1982-07-27 1983-12-27 The University Of Pennsylvania Perfluorochemical emulsion artificial blood
JPS5946218A (ja) * 1982-09-09 1984-03-15 Green Cross Corp:The フルオロカ−ボン乳化製剤
JPS59175421A (ja) * 1983-03-24 1984-10-04 Tetsuzou Agishi 血液浄化剤
AU2441592A (en) * 1991-08-08 1993-03-02 Leigh D. Segel Fluorocarbon blood substitute
US5502094A (en) * 1994-05-20 1996-03-26 Minnesota Mining And Manufacturing Company Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods for use
US5658962A (en) 1994-05-20 1997-08-19 Minnesota Mining And Manufacturing Company Omega-hydrofluoroalkyl ethers, precursor carboxylic acids and derivatives thereof, and their preparation and application
WO1997025978A1 (fr) * 1996-01-15 1997-07-24 BELOYARTSEV, Arkady Felixovich Procede de production d'emulsions perfluorocarbonees a des fins medicales
CN1068778C (zh) * 1998-05-15 2001-07-25 赵超英 救治用的药物组合物及其制备方法
US7357937B2 (en) 2002-09-24 2008-04-15 Therox, Inc. Perfluorocarbon emulsions with non-fluorinated surfactants
RU2259819C1 (ru) 2004-03-01 2005-09-10 Кузнецова Ирина Николаевна Эмульсия перфторорганических соединений медицинского назначения и способ её получения
EP2005948A2 (fr) 2006-03-14 2008-12-24 Sergey Ivanovich Vorobyev Émulsion perfluorocarbonée de transfert de gaz destinée à une utilisation médicale et biologique : composition, procédé de production et agent curatif (variantes)
US8063020B2 (en) * 2007-12-22 2011-11-22 Simpkins Cuthbert O Resuscitation fluid
GB2467353B (en) * 2009-01-30 2011-07-20 Steven Skill Apparatus for treatment of fluid streams and method of conducting the same
ES2541226B2 (es) * 2014-01-15 2016-02-12 MONDRAGÓN GOI ESKOLA POLITEKNIKOA J. Mª. ARIZMENDIARRIETA, S.C Fantoma de sangre
RU2745290C2 (ru) * 2019-04-12 2021-03-23 Ирина Николаевна Кузнецова Эмульсия перфторуглеродных соединений медико-биологического назначения и способ её получения
WO2024046999A1 (fr) * 2022-08-31 2024-03-07 Johann Wolfgang Goethe-Universität Frankfurt am Main Transporteurs d'oxygène à l'échelle nanométrique modifiés par la lécithine (lenox)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH604490A5 (fr) * 1970-09-05 1978-09-15 Green Cross Corp
JPS5331209B2 (fr) * 1973-10-05 1978-09-01

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2447195A1 (fr) * 1979-01-25 1980-08-22 Wada Juro Composition de contraste pour angiographie

Also Published As

Publication number Publication date
NL171533C (nl) 1983-04-18
CH633674A5 (en) 1982-12-31
FR2361867B1 (fr) 1978-12-15
BE850992A (fr) 1977-05-31
NO145370C (no) 1982-03-10
NZ183096A (en) 1979-04-26
JPS5296722A (en) 1977-08-13
NO145370B (no) 1981-11-30
FI58071B (fi) 1980-08-29
FI770354A (fr) 1977-08-04
DD132231A5 (de) 1978-09-13
AU1550576A (en) 1977-07-28
CA1072446A (fr) 1980-02-26
DK152256B (da) 1988-02-15
SU797546A3 (ru) 1981-01-15
AR218864A1 (es) 1980-07-15
DK152256C (da) 1988-08-29
FI58071C (fi) 1980-12-10
SE442706B (sv) 1986-01-27
ATA496676A (de) 1979-07-15
DK307276A (da) 1977-08-04
JPS5835485B2 (ja) 1983-08-03
GB1549038A (en) 1979-08-01
NL171533B (nl) 1982-11-16
DE2630586A1 (de) 1977-08-11
IL51325A (en) 1980-05-30
NO770324L (no) 1977-08-04
ES449635A1 (es) 1977-11-16
SE7607727L (sv) 1977-08-04
LU76698A1 (fr) 1977-06-28
NL7607514A (nl) 1977-08-05
ZA77229B (en) 1977-11-30
IL51325A0 (en) 1977-03-31
AT355214B (de) 1980-02-25
MX4136E (es) 1982-01-06
DE2630586C2 (de) 1984-06-07

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