FR2355804A1 - Nouveau polypeptide, son procede de preparation et composition pharmaceutique le contenant - Google Patents

Nouveau polypeptide, son procede de preparation et composition pharmaceutique le contenant

Info

Publication number
FR2355804A1
FR2355804A1 FR7718848A FR7718848A FR2355804A1 FR 2355804 A1 FR2355804 A1 FR 2355804A1 FR 7718848 A FR7718848 A FR 7718848A FR 7718848 A FR7718848 A FR 7718848A FR 2355804 A1 FR2355804 A1 FR 2355804A1
Authority
FR
France
Prior art keywords
lys
ala
asn
pharmaceutical composition
composition containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7718848A
Other languages
English (en)
Other versions
FR2355804B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB2564376A external-priority patent/GB1524319A/en
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of FR2355804A1 publication Critical patent/FR2355804A1/fr
Application granted granted Critical
Publication of FR2355804B1 publication Critical patent/FR2355804B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/675—Beta-endorphins
    • C07K14/6755—Beta-endorphins with at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/67—Lipotropins, e.g. beta, gamma lipotropin
    • C07K14/672—Lipotropins, e.g. beta, gamma lipotropin with at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne un polypeptide nouveau de formule : H-Tyr-A-Gly-Phe-B-P-E (dans laquelle : A représente D-Ala, D-Ser, D-Met ou Gly; B représente Leu ou Met; E représente un radical hydroxy ou amino ou un radical alkoxy ayant 1 à 6 atomes de carbone et P représente un résidu peptidique de formule : Lys-Lys Asn-Ala-Y-Lys-Lys Ala-Ile-X-Lys-Asn-Ala-Y-Lys-Lys Thr-Leu-Phe-Lys-Asn-Ala-Ile-X-Lys-Asn-Ala-Y-Lys-Lys
FR7718848A 1976-06-21 1977-06-20 Nouveau polypeptide, son procede de preparation et composition pharmaceutique le contenant Granted FR2355804A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2564376A GB1524319A (en) 1976-06-21 1976-06-21 Polypeptide
GB4484076 1976-10-28

Publications (2)

Publication Number Publication Date
FR2355804A1 true FR2355804A1 (fr) 1978-01-20
FR2355804B1 FR2355804B1 (fr) 1980-02-01

Family

ID=26257785

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7718848A Granted FR2355804A1 (fr) 1976-06-21 1977-06-20 Nouveau polypeptide, son procede de preparation et composition pharmaceutique le contenant

Country Status (4)

Country Link
US (1) US4123523A (fr)
JP (1) JPS52156832A (fr)
DE (1) DE2727847A1 (fr)
FR (1) FR2355804A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2383164A1 (fr) * 1977-03-11 1978-10-06 Hoffmann La Roche Nouveaux polypeptides analogues de la b-endorphine et procede pour leur preparation

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1604850A (en) * 1977-11-24 1981-12-16 Wellcome Found Biologically active peptides
GB1604644A (en) * 1977-07-22 1981-12-09 Wellcome Found Biologically active pentapeptide amides
DE2936099A1 (de) * 1979-09-06 1981-04-02 Victor Dipl.- Chem. 8000 München Brantl Pharmakologisch aktive peptide
US4396606A (en) * 1979-11-05 1983-08-02 Addiction Research Foundation Novel polypeptide analgesics
JPH0680079B2 (ja) * 1984-11-09 1994-10-12 エーザイ株式会社 ポリペプチド
US6184208B1 (en) 1994-06-29 2001-02-06 Immunotech Developments Inc. Peptide, a method for its preparation and a pharmaceutical composition containing the peptide
WO2008079818A2 (fr) * 2006-12-21 2008-07-03 Soluprin Pharmaceuticals, Inc. Administration intraveineuse de formulations analgésiques hydrosolubles

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4038222A (en) * 1976-03-17 1977-07-26 Hoffman-La Roche Inc. Untriakontapeptide with opiate activity

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2383164A1 (fr) * 1977-03-11 1978-10-06 Hoffmann La Roche Nouveaux polypeptides analogues de la b-endorphine et procede pour leur preparation

Also Published As

Publication number Publication date
US4123523A (en) 1978-10-31
FR2355804B1 (fr) 1980-02-01
JPS52156832A (en) 1977-12-27
DE2727847A1 (de) 1977-12-29

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Legal Events

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