FR2346331A2 - L-Hydroxy proline from material contg. collagen - by hydrolysis and multistage ion exchanger treatment - Google Patents

L-Hydroxy proline from material contg. collagen - by hydrolysis and multistage ion exchanger treatment

Info

Publication number
FR2346331A2
FR2346331A2 FR7609288A FR7609288A FR2346331A2 FR 2346331 A2 FR2346331 A2 FR 2346331A2 FR 7609288 A FR7609288 A FR 7609288A FR 7609288 A FR7609288 A FR 7609288A FR 2346331 A2 FR2346331 A2 FR 2346331A2
Authority
FR
France
Prior art keywords
ion exchanger
collagen
soln
hydrolysis
decolorising
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7609288A
Other languages
French (fr)
Other versions
FR2346331B2 (en
Inventor
Patrice Henri Brunet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SOLABIA
Original Assignee
SOLABIA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SOLABIA filed Critical SOLABIA
Priority to FR7609288A priority Critical patent/FR2346331A2/en
Priority to GB1606176A priority patent/GB1499086A/en
Priority to IT6804876A priority patent/IT1059949B/en
Priority to ES76448035A priority patent/ES448035A1/en
Priority to CS316376A priority patent/CS203123B2/en
Priority to DE19762620834 priority patent/DE2620834A1/en
Priority to BR7602952A priority patent/BR7602952A/en
Publication of FR2346331A2 publication Critical patent/FR2346331A2/en
Application granted granted Critical
Publication of FR2346331B2 publication Critical patent/FR2346331B2/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L-(-)-4-Hydroxyproline (I) is obtd. by (a) hydrolysing an opt. pretreated collagen-contg. material; (b) decolorising the resulting protein hydrolysated and passing it through a weakly basic ion exchange to retain glutamic acid, aspartic acid and inorganic anions; (c) contacting the effluent with as strongly acidic ion exchanger to retain 75-95% of a amino acids present in the soln.; (d) eluting with H2O and concentrating the eluate to give a soln. with a (I) concn. of 180-350 (pref. 230-280) g/l; and (e) decolorising the soln., adjusting to pH 3.8-4.6, and isolating (I) in crystalline form. The process requires only small amts. of ion exchanger, avoids the use of buffers, and can be applied to materials with a low collagen content.
FR7609288A 1975-05-12 1976-03-31 L-Hydroxy proline from material contg. collagen - by hydrolysis and multistage ion exchanger treatment Granted FR2346331A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
FR7609288A FR2346331A2 (en) 1976-03-31 1976-03-31 L-Hydroxy proline from material contg. collagen - by hydrolysis and multistage ion exchanger treatment
GB1606176A GB1499086A (en) 1975-05-12 1976-04-21 Process for the preparation of 4-hydroxy-l-(-)-proline
IT6804876A IT1059949B (en) 1975-05-12 1976-04-29 PROCEDURE FOR THE PREPARATION OF L HYDROXYPROLIN
ES76448035A ES448035A1 (en) 1975-05-12 1976-05-11 Process for the preparation of 4-hydroxy-l-(-)-proline
CS316376A CS203123B2 (en) 1975-05-12 1976-05-11 Method of producing 4-hydroxy-l-proline
DE19762620834 DE2620834A1 (en) 1975-05-12 1976-05-11 PROCESS FOR THE PREPARATION OF 4-HYDROXY L (-) PROLIN
BR7602952A BR7602952A (en) 1975-05-12 1976-05-11 PROCESS FOR THE PREPARATION OF 4-HYDROXYL - (-) PROLINE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7609288A FR2346331A2 (en) 1976-03-31 1976-03-31 L-Hydroxy proline from material contg. collagen - by hydrolysis and multistage ion exchanger treatment

Publications (2)

Publication Number Publication Date
FR2346331A2 true FR2346331A2 (en) 1977-10-28
FR2346331B2 FR2346331B2 (en) 1978-08-25

Family

ID=9171192

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7609288A Granted FR2346331A2 (en) 1975-05-12 1976-03-31 L-Hydroxy proline from material contg. collagen - by hydrolysis and multistage ion exchanger treatment

Country Status (1)

Country Link
FR (1) FR2346331A2 (en)

Also Published As

Publication number Publication date
FR2346331B2 (en) 1978-08-25

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