FR2344563A1 - Derive bis-trimethylsilyle de l'acide 7-(d-mandelamido)-3-(1-methyl-1,2,3,4-tetrazol-5-yl) thiomethyl-3-cephem-4-carboxylique, sa preparation et son utilisation pour purifier la forme acide du compose - Google Patents
Derive bis-trimethylsilyle de l'acide 7-(d-mandelamido)-3-(1-methyl-1,2,3,4-tetrazol-5-yl) thiomethyl-3-cephem-4-carboxylique, sa preparation et son utilisation pour purifier la forme acide du composeInfo
- Publication number
- FR2344563A1 FR2344563A1 FR7708037A FR7708037A FR2344563A1 FR 2344563 A1 FR2344563 A1 FR 2344563A1 FR 7708037 A FR7708037 A FR 7708037A FR 7708037 A FR7708037 A FR 7708037A FR 2344563 A1 FR2344563 A1 FR 2344563A1
- Authority
- FR
- France
- Prior art keywords
- mandelamido
- cephem
- thiomethyl
- tetrazol
- purify
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/667,753 US4035361A (en) | 1976-03-17 | 1976-03-17 | Bis-trimethylsilyl cefamandole and process therefor |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2344563A1 true FR2344563A1 (fr) | 1977-10-14 |
FR2344563B1 FR2344563B1 (fr) | 1980-03-28 |
Family
ID=24679489
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7708037A Granted FR2344563A1 (fr) | 1976-03-17 | 1977-03-17 | Derive bis-trimethylsilyle de l'acide 7-(d-mandelamido)-3-(1-methyl-1,2,3,4-tetrazol-5-yl) thiomethyl-3-cephem-4-carboxylique, sa preparation et son utilisation pour purifier la forme acide du compose |
Country Status (12)
Country | Link |
---|---|
US (1) | US4035361A (fr) |
JP (1) | JPS5934199B2 (fr) |
BE (1) | BE852487A (fr) |
CA (1) | CA1077926A (fr) |
CH (2) | CH627472A5 (fr) |
DE (1) | DE2711095C2 (fr) |
ES (2) | ES456689A1 (fr) |
FR (1) | FR2344563A1 (fr) |
GB (1) | GB1544178A (fr) |
IE (1) | IE44605B1 (fr) |
IL (1) | IL51509A (fr) |
NL (1) | NL7702634A (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4148817A (en) * | 1976-03-25 | 1979-04-10 | Eli Lilly And Company | Process and intermediates for preparing cephalosporin antibiotics |
US4223134A (en) * | 1978-11-28 | 1980-09-16 | Eli Lilly And Company | Process for preparing cephalosporin antibiotics |
GB9503717D0 (en) * | 1995-02-24 | 1995-04-12 | Smithkline Beecham Plc | Novel compounds |
CN104530086B (zh) * | 2014-12-16 | 2015-12-09 | 天津大学 | 头孢孟多酯钠化合物的新晶型及其结晶制备方法 |
US9834567B1 (en) * | 2014-12-16 | 2017-12-05 | Tianjin University | Crystalline form of cefamandole nafate compound, preparation and preparing method thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3641021A (en) * | 1969-04-18 | 1972-02-08 | Lilly Co Eli | 3 7-(ring-substituted) cephalosporin compounds |
US3694437A (en) * | 1970-08-19 | 1972-09-26 | Lilly Co Eli | Process for preparing cephalosporin compounds |
US3840531A (en) * | 1972-03-21 | 1974-10-08 | Lilly Co Eli | Process for preparing 7-(alpha-hydroxy-alpha-phenyl)acetamido-3-(1-methyl-1h-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid and derivatives thereof |
-
1976
- 1976-03-17 US US05/667,753 patent/US4035361A/en not_active Expired - Lifetime
-
1977
- 1977-02-15 CA CA271,851A patent/CA1077926A/fr not_active Expired
- 1977-02-15 IE IE322/77A patent/IE44605B1/en not_active IP Right Cessation
- 1977-02-21 IL IL51509A patent/IL51509A/xx unknown
- 1977-03-09 ES ES456689A patent/ES456689A1/es not_active Expired
- 1977-03-10 NL NL7702634A patent/NL7702634A/xx not_active Application Discontinuation
- 1977-03-11 GB GB10324/77A patent/GB1544178A/en not_active Expired
- 1977-03-14 DE DE2711095A patent/DE2711095C2/de not_active Expired
- 1977-03-14 ES ES456823A patent/ES456823A1/es not_active Expired
- 1977-03-15 BE BE1008011A patent/BE852487A/fr not_active IP Right Cessation
- 1977-03-16 CH CH329977A patent/CH627472A5/de not_active IP Right Cessation
- 1977-03-16 JP JP52029137A patent/JPS5934199B2/ja not_active Expired
- 1977-03-17 FR FR7708037A patent/FR2344563A1/fr active Granted
-
1981
- 1981-02-05 CH CH77881A patent/CH630640A5/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NL7702634A (nl) | 1977-09-20 |
ES456823A1 (es) | 1978-02-16 |
US4035361A (en) | 1977-07-12 |
CA1077926A (fr) | 1980-05-20 |
CH627472A5 (de) | 1982-01-15 |
CH630640A5 (de) | 1982-06-30 |
GB1544178A (en) | 1979-04-11 |
JPS5934199B2 (ja) | 1984-08-21 |
BE852487A (fr) | 1977-09-15 |
ES456689A1 (es) | 1978-01-16 |
JPS52113993A (en) | 1977-09-24 |
DE2711095C2 (de) | 1982-03-11 |
IE44605L (en) | 1977-09-17 |
DE2711095A1 (de) | 1977-09-22 |
FR2344563B1 (fr) | 1980-03-28 |
IL51509A (en) | 1979-11-30 |
IL51509A0 (en) | 1977-04-29 |
IE44605B1 (en) | 1982-01-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |