FR2342303A1 - Polyhalogenated dihydroxyisopropylidenedioxy-pregnadiene diones - with antiinflammatory properties (BE 23.8.77) - Google Patents
Polyhalogenated dihydroxyisopropylidenedioxy-pregnadiene diones - with antiinflammatory properties (BE 23.8.77)Info
- Publication number
- FR2342303A1 FR2342303A1 FR7705054A FR7705054A FR2342303A1 FR 2342303 A1 FR2342303 A1 FR 2342303A1 FR 7705054 A FR7705054 A FR 7705054A FR 7705054 A FR7705054 A FR 7705054A FR 2342303 A1 FR2342303 A1 FR 2342303A1
- Authority
- FR
- France
- Prior art keywords
- polyhalogenated
- alpha
- dihydroxyisopropylidenedioxy
- pregnadiene
- diones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Polyhalogenated pregnane derivs. of formula (I) are new:-(where X is F or Cl; and R is OH or an esterified OH gp. or Cl). (I) have excellent anti inflammatory properties and are pref. administered topically but may also be administered orally or parenterally. Specifically claimed is 2-chloro-6 alpha, 9 alpha-difluoro-11 beta, 21-dihydroxy-16 alpha, 17 alpha-iso-propylidene-dioxy-pregna-1,4-diene-3,20-dione and its 21-acetate and 21-valerate.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH225476 | 1976-02-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2342303A1 true FR2342303A1 (en) | 1977-09-23 |
| FR2342303B1 FR2342303B1 (en) | 1979-03-09 |
Family
ID=4229470
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7705054A Granted FR2342303A1 (en) | 1976-02-24 | 1977-02-22 | Polyhalogenated dihydroxyisopropylidenedioxy-pregnadiene diones - with antiinflammatory properties (BE 23.8.77) |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS52102265A (en) |
| AT (1) | ATA119377A (en) |
| AU (1) | AU2257377A (en) |
| BE (1) | BE851726A (en) |
| DD (1) | DD129653A5 (en) |
| DE (1) | DE2707346A1 (en) |
| DK (1) | DK78977A (en) |
| ES (5) | ES456135A1 (en) |
| FR (1) | FR2342303A1 (en) |
| IL (1) | IL51524A0 (en) |
| NL (1) | NL7701324A (en) |
| NZ (1) | NZ183417A (en) |
| SE (1) | SE7702000L (en) |
| ZA (1) | ZA771088B (en) |
-
1977
- 1977-01-21 DD DD7700197484A patent/DD129653A5/en unknown
- 1977-02-08 NL NL7701324A patent/NL7701324A/en not_active Application Discontinuation
- 1977-02-19 DE DE19772707346 patent/DE2707346A1/en active Pending
- 1977-02-22 FR FR7705054A patent/FR2342303A1/en active Granted
- 1977-02-22 ES ES456135A patent/ES456135A1/en not_active Expired
- 1977-02-23 SE SE7702000A patent/SE7702000L/en unknown
- 1977-02-23 DK DK78977A patent/DK78977A/en not_active Application Discontinuation
- 1977-02-23 ZA ZA00771088A patent/ZA771088B/en unknown
- 1977-02-23 BE BE175170A patent/BE851726A/en unknown
- 1977-02-23 AT AT119377A patent/ATA119377A/en not_active IP Right Cessation
- 1977-02-23 AU AU22573/77A patent/AU2257377A/en not_active Expired
- 1977-02-23 NZ NZ183417A patent/NZ183417A/en unknown
- 1977-02-23 IL IL51524A patent/IL51524A0/en unknown
- 1977-02-24 JP JP1874477A patent/JPS52102265A/en active Pending
-
1978
- 1978-03-01 ES ES467436A patent/ES467436A1/en not_active Expired
- 1978-03-01 ES ES467437A patent/ES467437A1/en not_active Expired
- 1978-03-01 ES ES467438A patent/ES467438A1/en not_active Expired
- 1978-03-01 ES ES467435A patent/ES467435A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ATA119377A (en) | 1979-08-15 |
| DK78977A (en) | 1977-08-25 |
| ES467438A1 (en) | 1979-09-01 |
| SE7702000L (en) | 1977-08-25 |
| IL51524A0 (en) | 1977-04-29 |
| AU2257377A (en) | 1978-08-31 |
| DE2707346A1 (en) | 1977-08-25 |
| DD129653A5 (en) | 1978-02-01 |
| ES467435A1 (en) | 1979-09-01 |
| ES467437A1 (en) | 1980-01-16 |
| NL7701324A (en) | 1977-08-26 |
| ES456135A1 (en) | 1978-05-01 |
| JPS52102265A (en) | 1977-08-27 |
| BE851726A (en) | 1977-08-23 |
| NZ183417A (en) | 1979-12-11 |
| ES467436A1 (en) | 1979-10-01 |
| FR2342303B1 (en) | 1979-03-09 |
| ZA771088B (en) | 1978-01-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO164905C (en) | PROCEDURE FOR THE PREPARATION OF 16,17-ACETAL PREGNANCY DERIVATIVES. | |
| JPS54128560A (en) | Hydrocortisone derivative | |
| IE44473L (en) | 6,9,21-trihalo pregnanes | |
| FR2342303A1 (en) | Polyhalogenated dihydroxyisopropylidenedioxy-pregnadiene diones - with antiinflammatory properties (BE 23.8.77) | |
| ES462763A1 (en) | 21-halogenopregnane compounds | |
| US2966486A (en) | 16alpha, 17alpha-substituted methylene dioxy ethers of steroids of the pregnane series and method of preparing the same | |
| GB898291A (en) | Improvements in or relating to steroids and the manufacture thereof | |
| US3519619A (en) | 16-alkylidene pregnanes and process for their manufacture | |
| ES412235A1 (en) | Anti-inflammatory pregnane derivative | |
| GB924931A (en) | ||
| US3721686A (en) | Novel 6alpha-fluoro-11beta-hydroxy-16alpha-methyl-21-halo-progesterones | |
| NL7603692A (en) | 21-Ester deriv of hydrocortisone, cortison, prednisone prednisolone - from steroid and ((1-benzyl-1H-indazol-3-yl)-oxy)acetyl chloride has anti-inflammatory props | |
| ES360114A1 (en) | New steroid derivatives | |
| ES471734A1 (en) | 9-Chloro-prednisolone 17-ester derivs. - with topical but not systemic antiinflammatory activity | |
| US3069418A (en) | 16alpha, 17alpha-cyclosulfate and cyclosulfite esters of steroids | |
| US3665017A (en) | Process for preparation of 6-azido-4,6-bis-dehydro-steroids | |
| US3029259A (en) | 9alpha-halo-4-pregnene-3, 20 diones and derivatives thereof | |
| US2938043A (en) | Preparation of pregnan-11 alpha, 17 alpha, 21 triol 3, 20 diones and the corresponding 4-pregnenes | |
| KR790000357B1 (en) | Process for preparation of an anti-inflamatory composition | |
| GB716676A (en) | Steroids | |
| GB923125A (en) | Steroid compounds | |
| IE35822B1 (en) | New 6alpha,16alpha-dimethyl-steroids | |
| GB926472A (en) | New halogen-pregnenes and a process for their manufacture | |
| GB1575983A (en) | 7-halo-3,20-soxo-1,4-pregnadienes and -4-pregnenes and their preparation | |
| IT1247692B (en) | 6-fluoro-6-methylpregn-4-ene-3,20-diones and 6-fluoro-6 methylpregna-1,4-diene-3,20-diones, process for their preparation and pharmaceutical compositions with anti inflammatory activity which contain them |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |