ES412235A1 - Anti-inflammatory pregnane derivative - Google Patents

Anti-inflammatory pregnane derivative

Info

Publication number
ES412235A1
ES412235A1 ES412235A ES412235A ES412235A1 ES 412235 A1 ES412235 A1 ES 412235A1 ES 412235 A ES412235 A ES 412235A ES 412235 A ES412235 A ES 412235A ES 412235 A1 ES412235 A1 ES 412235A1
Authority
ES
Spain
Prior art keywords
inflammatory
pregnane derivative
methylpregna
dien
dione
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES412235A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of ES412235A1 publication Critical patent/ES412235A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Process for producing acetates, especially 6α-fluoro-17,21-dihydroxy16β-methylpregna-4,9- (11) -dien-3,20-dione, 17,21-diacetate, characterized in that 21-acetate of 6α-fluoro-17,21 -dihydroxy-16β-methylpregna-4,9- (11) -dien-3,20-dione with an acetylating agent in the presence of an acetylation promoter and a strong acid. (Machine-translation by Google Translate, not legally binding)
ES412235A 1972-03-09 1973-03-02 Anti-inflammatory pregnane derivative Expired ES412235A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23333772A 1972-03-09 1972-03-09
US31697372A 1972-12-20 1972-12-20

Publications (1)

Publication Number Publication Date
ES412235A1 true ES412235A1 (en) 1976-01-01

Family

ID=26926821

Family Applications (1)

Application Number Title Priority Date Filing Date
ES412235A Expired ES412235A1 (en) 1972-03-09 1973-03-02 Anti-inflammatory pregnane derivative

Country Status (13)

Country Link
JP (3) JPS5331156B2 (en)
AR (1) AR197216A1 (en)
AU (1) AU468257B2 (en)
CH (3) CH580117A5 (en)
DE (1) DE2365992C3 (en)
DK (1) DK133382B (en)
ES (1) ES412235A1 (en)
FR (1) FR2181802B1 (en)
GB (1) GB1403962A (en)
HK (1) HK62680A (en)
NL (1) NL165178C (en)
PH (1) PH14703A (en)
SE (1) SE396756B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1430223A (en) * 1973-10-25 1976-03-31 Upjohn Co Anti-inflammatory composition comprising steroids
ZA77943B (en) * 1976-03-19 1977-12-28 Upjohn Co Topical steroid clindamycin preparations
NL187577C (en) * 1978-04-05 1991-11-18 Sibla Srl 3-ACETOXY-9BETA, 11BETA-EPOXY-PREGNA-1,3,5-TRIEN, PROCESS FOR THE PREPARATION THEREOF, AND PROCESS FOR THE PREPARATION OF 6-alpha-halogen-1,4-diene-3-ones.
DE3071122D1 (en) 1979-11-16 1985-10-31 Sterosynt Ltd 6-alpha-fluoro-9-alpha-chloro-prednisolone-17,21 diesters, pharmaceutical compositions containing them and intermediates
JPH0240957Y2 (en) * 1986-08-30 1990-10-31

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB933859A (en) * 1958-09-06 1963-08-14 Syntex S.A.

Also Published As

Publication number Publication date
AR197216A1 (en) 1974-03-22
FR2181802B1 (en) 1976-10-22
DE2365992A1 (en) 1977-05-18
DK133382B (en) 1976-05-10
FR2181802A1 (en) 1973-12-07
DE2365992C3 (en) 1982-05-19
JPS5344464B2 (en) 1978-11-29
PH14703A (en) 1981-11-10
CH580117A5 (en) 1976-09-30
NL165178B (en) 1980-10-15
CH580118A5 (en) 1976-09-30
NL7303262A (en) 1973-09-11
HK62680A (en) 1980-11-14
AU5257973A (en) 1974-08-29
JPS5227761A (en) 1977-03-02
JPS4899157A (en) 1973-12-15
CH580116A5 (en) 1976-09-30
JPS5331156B2 (en) 1978-08-31
JPS5227760A (en) 1977-03-02
GB1403962A (en) 1975-08-28
JPS5344465B2 (en) 1978-11-29
DK133382C (en) 1976-10-04
AU468257B2 (en) 1976-01-08
SE396756B (en) 1977-10-03
NL165178C (en) 1981-03-16
DE2365992B2 (en) 1981-08-06

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