IT1247692B - 6-fluoro-6-methylpregn-4-ene-3,20-diones and 6-fluoro-6 methylpregna-1,4-diene-3,20-diones, process for their preparation and pharmaceutical compositions with anti inflammatory activity which contain them - Google Patents
6-fluoro-6-methylpregn-4-ene-3,20-diones and 6-fluoro-6 methylpregna-1,4-diene-3,20-diones, process for their preparation and pharmaceutical compositions with anti inflammatory activity which contain themInfo
- Publication number
- IT1247692B IT1247692B IT04803190A IT4803190A IT1247692B IT 1247692 B IT1247692 B IT 1247692B IT 04803190 A IT04803190 A IT 04803190A IT 4803190 A IT4803190 A IT 4803190A IT 1247692 B IT1247692 B IT 1247692B
- Authority
- IT
- Italy
- Prior art keywords
- diones
- fluoro
- methylpregn
- methylpregna
- ene
- Prior art date
Links
- ZGJRALRSTICMOK-BFGPNBGYSA-N FC1(C[C@H]2[C@@H]3CC[C@H](C(C)=O)[C@]3(CC[C@@H]2[C@]2(C=CC(C=C12)=O)C)C)C Chemical class FC1(C[C@H]2[C@@H]3CC[C@H](C(C)=O)[C@]3(CC[C@@H]2[C@]2(C=CC(C=C12)=O)C)C)C ZGJRALRSTICMOK-BFGPNBGYSA-N 0.000 title abstract 2
- WCMOPGPMCAOSMH-BFGPNBGYSA-N FC1(C[C@H]2[C@@H]3CC[C@H](C(C)=O)[C@]3(CC[C@@H]2[C@]2(CCC(C=C12)=O)C)C)C Chemical class FC1(C[C@H]2[C@@H]3CC[C@H](C(C)=O)[C@]3(CC[C@@H]2[C@]2(CCC(C=C12)=O)C)C)C WCMOPGPMCAOSMH-BFGPNBGYSA-N 0.000 title abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
Landscapes
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
6-fluoro-6-methylpregn-4-ene-3,20-diones and 6-fluoro-6- methylpregna-1,4-diene-3,20-diones of general formula <IMAGE> where: in the positions 1 and 2 the bond can be single or double, X is hydroxy and Y is hydrogen, fluorine, chlorine or bromine, or else X and Y are both chlorine, R1 is hydroxy or acyloxy having from 2 to 12 carbon atoms, R2 is hydroxy or acyloxy having from 2 to 12 carbon atoms, R3 is hydrogen, α-hydroxy, α-methyl or β-methyl, and their 16,17- and 17,21- cyclic acetals and ketals, particularly the 16,17-acetonides, display high anti-inflammatory activity but less undesired side-effects than the known steroids.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT04803190A IT1247692B (en) | 1990-06-06 | 1990-06-06 | 6-fluoro-6-methylpregn-4-ene-3,20-diones and 6-fluoro-6 methylpregna-1,4-diene-3,20-diones, process for their preparation and pharmaceutical compositions with anti inflammatory activity which contain them |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT04803190A IT1247692B (en) | 1990-06-06 | 1990-06-06 | 6-fluoro-6-methylpregn-4-ene-3,20-diones and 6-fluoro-6 methylpregna-1,4-diene-3,20-diones, process for their preparation and pharmaceutical compositions with anti inflammatory activity which contain them |
Publications (3)
Publication Number | Publication Date |
---|---|
IT9048031A0 IT9048031A0 (en) | 1990-06-06 |
IT9048031A1 IT9048031A1 (en) | 1991-12-06 |
IT1247692B true IT1247692B (en) | 1994-12-30 |
Family
ID=11264073
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT04803190A IT1247692B (en) | 1990-06-06 | 1990-06-06 | 6-fluoro-6-methylpregn-4-ene-3,20-diones and 6-fluoro-6 methylpregna-1,4-diene-3,20-diones, process for their preparation and pharmaceutical compositions with anti inflammatory activity which contain them |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1247692B (en) |
-
1990
- 1990-06-06 IT IT04803190A patent/IT1247692B/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
IT9048031A1 (en) | 1991-12-06 |
IT9048031A0 (en) | 1990-06-06 |
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