FR2317913A2 - Substd. phenyl-guanidines and salts - useful as antihypertensive agents - Google Patents
Substd. phenyl-guanidines and salts - useful as antihypertensive agentsInfo
- Publication number
- FR2317913A2 FR2317913A2 FR7522078A FR7522078A FR2317913A2 FR 2317913 A2 FR2317913 A2 FR 2317913A2 FR 7522078 A FR7522078 A FR 7522078A FR 7522078 A FR7522078 A FR 7522078A FR 2317913 A2 FR2317913 A2 FR 2317913A2
- Authority
- FR
- France
- Prior art keywords
- salts
- useful
- alkyl
- antihypertensive agents
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/24—Derivatives of thiourea containing any of the groups, X being a hetero atom, Y being any atom
- C07C335/28—Y being a hetero atom, e.g. thiobiuret
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Cpds. of formula (I) and their pharm. acceptable acid addn. salts are new (where X is H or halo, Y is H, halo, haloalkyl, NO2, alkyl or alkoxy, Z is haloalkyl, haloalkoxy, or alkylsulphonyl, and can also be halo, alkyl, alkoxy NO2 or CN provided X and Y are not both H at the same time, R is H or lower alkyl, R' and R"' are H, acetyl or propionyl, and R" is acetyl or propionyl). All alkyl etc. are lower. (I) are useful as antihypertensive agents with minimum side effects and can be used for treating cardiovascular disorders. I are also intermediates for the prepn. of amidinourea cpds. which are anti-hypertensive agents.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7522078A FR2317913A2 (en) | 1972-09-22 | 1975-07-15 | Substd. phenyl-guanidines and salts - useful as antihypertensive agents |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29147472A | 1972-09-22 | 1972-09-22 | |
FR7522078A FR2317913A2 (en) | 1972-09-22 | 1975-07-15 | Substd. phenyl-guanidines and salts - useful as antihypertensive agents |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2317913A2 true FR2317913A2 (en) | 1977-02-11 |
FR2317913B2 FR2317913B2 (en) | 1982-07-09 |
Family
ID=26218978
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7522078A Granted FR2317913A2 (en) | 1972-09-22 | 1975-07-15 | Substd. phenyl-guanidines and salts - useful as antihypertensive agents |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2317913A2 (en) |
-
1975
- 1975-07-15 FR FR7522078A patent/FR2317913A2/en active Granted
Also Published As
Publication number | Publication date |
---|---|
FR2317913B2 (en) | 1982-07-09 |
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