FR2311022A1 - Tri-hydroxymethyl-amino methane-gluconate dihydroxy-aluminate prepn. - by reacting gluconic acid with aluminium isopropylate and gluconate with tri-hydroxymethyl aminomethane - Google Patents
Tri-hydroxymethyl-amino methane-gluconate dihydroxy-aluminate prepn. - by reacting gluconic acid with aluminium isopropylate and gluconate with tri-hydroxymethyl aminomethaneInfo
- Publication number
- FR2311022A1 FR2311022A1 FR7515039A FR7515039A FR2311022A1 FR 2311022 A1 FR2311022 A1 FR 2311022A1 FR 7515039 A FR7515039 A FR 7515039A FR 7515039 A FR7515039 A FR 7515039A FR 2311022 A1 FR2311022 A1 FR 2311022A1
- Authority
- FR
- France
- Prior art keywords
- gluconate
- tri
- hydroxymethyl
- aluminate
- dihydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 title abstract 2
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 title abstract 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 title abstract 2
- 229940050410 gluconate Drugs 0.000 title abstract 2
- 235000012208 gluconic acid Nutrition 0.000 title abstract 2
- FYFFGSSZFBZTAH-UHFFFAOYSA-N methylaminomethanetriol Chemical compound CNC(O)(O)O FYFFGSSZFBZTAH-UHFFFAOYSA-N 0.000 title abstract 2
- LMHHRCOWPQNFTF-UHFFFAOYSA-N s-propan-2-yl azepane-1-carbothioate Chemical compound CC(C)SC(=O)N1CCCCCC1 LMHHRCOWPQNFTF-UHFFFAOYSA-N 0.000 title abstract 2
- WXVNBNUSUPSSIT-JJKGCWMISA-N O=C([C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)O.OC(O)(O)CN Chemical compound O=C([C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)O.OC(O)(O)CN WXVNBNUSUPSSIT-JJKGCWMISA-N 0.000 title 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 title 1
- 229910052782 aluminium Inorganic materials 0.000 title 1
- 239000004411 aluminium Substances 0.000 title 1
- 239000000174 gluconic acid Substances 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 1
- GJJYZOBRHIMORS-GQOAHPRESA-K aloglutamol Chemical compound OCC(N)(CO)CO.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(=O)O[Al](O)O GJJYZOBRHIMORS-GQOAHPRESA-K 0.000 abstract 1
- 239000000872 buffer Substances 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229950006191 gluconic acid Drugs 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/06—Aluminium compounds
- C07F5/069—Aluminium compounds without C-aluminium linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Industrial-scale prpn. of tris(hydroxymethyl) amino methane-gluconate-dihydroxy-aluminate having formula (HO)2Al-O-CH2-(CHOH)4-COOH.NH2 (CH2OH)3 (I) takes place in 2 steps. (1) reaction of D-gluconic acid with Al isopropylate, pref. with stirring at 30-80 (60-70) degrees C and (2) reaction of Al gluconate obtd. with tri-hydroxymethyl aminomethane. (I) has acid-inhibiting activity, high neutralising effect and buffer activity.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7515039A FR2311022A1 (en) | 1975-05-14 | 1975-05-14 | Tri-hydroxymethyl-amino methane-gluconate dihydroxy-aluminate prepn. - by reacting gluconic acid with aluminium isopropylate and gluconate with tri-hydroxymethyl aminomethane |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7515039A FR2311022A1 (en) | 1975-05-14 | 1975-05-14 | Tri-hydroxymethyl-amino methane-gluconate dihydroxy-aluminate prepn. - by reacting gluconic acid with aluminium isopropylate and gluconate with tri-hydroxymethyl aminomethane |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2311022A1 true FR2311022A1 (en) | 1976-12-10 |
| FR2311022B1 FR2311022B1 (en) | 1979-01-19 |
Family
ID=9155232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7515039A Granted FR2311022A1 (en) | 1975-05-14 | 1975-05-14 | Tri-hydroxymethyl-amino methane-gluconate dihydroxy-aluminate prepn. - by reacting gluconic acid with aluminium isopropylate and gluconate with tri-hydroxymethyl aminomethane |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2311022A1 (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE666769A (en) * | 1964-07-17 | 1965-11-03 | ||
| GB1044301A (en) * | 1962-04-24 | 1966-09-28 | Beecham Group Ltd | Analgesic chelate compounds |
-
1975
- 1975-05-14 FR FR7515039A patent/FR2311022A1/en active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1044301A (en) * | 1962-04-24 | 1966-09-28 | Beecham Group Ltd | Analgesic chelate compounds |
| BE666769A (en) * | 1964-07-17 | 1965-11-03 |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2311022B1 (en) | 1979-01-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |