FR2299313A1 - Procede de purification de l'insuline - Google Patents
Procede de purification de l'insulineInfo
- Publication number
- FR2299313A1 FR2299313A1 FR7503299A FR7503299A FR2299313A1 FR 2299313 A1 FR2299313 A1 FR 2299313A1 FR 7503299 A FR7503299 A FR 7503299A FR 7503299 A FR7503299 A FR 7503299A FR 2299313 A1 FR2299313 A1 FR 2299313A1
- Authority
- FR
- France
- Prior art keywords
- insulin
- permits
- alkali metal
- column
- ammonium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 23
- 102000004877 Insulin Human genes 0.000 title abstract 11
- 108090001061 Insulin Proteins 0.000 title abstract 11
- 229940125396 insulin Drugs 0.000 title abstract 11
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 title abstract 2
- 229910052783 alkali metal Inorganic materials 0.000 title abstract 2
- 150000001340 alkali metals Chemical class 0.000 title abstract 2
- 238000002523 gelfiltration Methods 0.000 title abstract 2
- 238000000746 purification Methods 0.000 title abstract 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052725 zinc Inorganic materials 0.000 abstract 2
- 239000011701 zinc Substances 0.000 abstract 2
- 102000005237 Isophane Insulin Human genes 0.000 abstract 1
- 108010081368 Isophane Insulin Proteins 0.000 abstract 1
- 102000007327 Protamines Human genes 0.000 abstract 1
- 108010007568 Protamines Proteins 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 235000015278 beef Nutrition 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 229940006445 isophane insulin Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 108010066090 neutral insulin Proteins 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 235000015277 pork Nutrition 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229940048914 protamine Drugs 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C07K14/625—Extraction from natural sources
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7503299A FR2299313A1 (fr) | 1975-02-03 | 1975-02-03 | Procede de purification de l'insuline |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7503299A FR2299313A1 (fr) | 1975-02-03 | 1975-02-03 | Procede de purification de l'insuline |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2299313A1 true FR2299313A1 (fr) | 1976-08-27 |
| FR2299313B1 FR2299313B1 (OSRAM) | 1977-07-22 |
Family
ID=9150664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7503299A Granted FR2299313A1 (fr) | 1975-02-03 | 1975-02-03 | Procede de purification de l'insuline |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2299313A1 (OSRAM) |
-
1975
- 1975-02-03 FR FR7503299A patent/FR2299313A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| FR2299313B1 (OSRAM) | 1977-07-22 |
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