FR2287226A1 - Procede de production de composes de butyrophenone a groupe 4-oxo-1-phenyl-1,3,8-triazaspiro (4,5) decane, nouveaux produits ainsi obtenus et leur utilisation comme produits a activites neuroleptique et analgesique - Google Patents
Procede de production de composes de butyrophenone a groupe 4-oxo-1-phenyl-1,3,8-triazaspiro (4,5) decane, nouveaux produits ainsi obtenus et leur utilisation comme produits a activites neuroleptique et analgesiqueInfo
- Publication number
- FR2287226A1 FR2287226A1 FR7538466A FR7538466A FR2287226A1 FR 2287226 A1 FR2287226 A1 FR 2287226A1 FR 7538466 A FR7538466 A FR 7538466A FR 7538466 A FR7538466 A FR 7538466A FR 2287226 A1 FR2287226 A1 FR 2287226A1
- Authority
- FR
- France
- Prior art keywords
- products
- triazaspiro
- neuroleptic
- decane
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 4-OXO-1-PHENYL-1,3,8-TRIAZASPIRO (4,5) DECANE BUTYROPHENONE COMPOUNDS Chemical class 0.000 title 1
- 230000000202 analgesic effect Effects 0.000 title 1
- 239000003176 neuroleptic agent Substances 0.000 title 1
- 230000000701 neuroleptic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP49044181A JPS595587B2 (ja) | 1974-04-18 | 1974-04-18 | シンキナブチロフエノンユウドウタイ オヨビ ソノエン ノ セイホウ |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2287226A1 true FR2287226A1 (fr) | 1976-05-07 |
FR2287226B1 FR2287226B1 (fr) | 1980-06-06 |
Family
ID=12684393
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7511865A Expired FR2267776B1 (fr) | 1974-04-18 | 1975-04-16 | |
FR7538465A Granted FR2287225A1 (fr) | 1974-04-18 | 1975-12-16 | Procede de production de composes de butyrophenone a groupes 2-oxo-benzimidazol-1-yl-4'-piperidino ou 2-oxo-benzimidazol-1-yl-4'-tetrahydropyridino, nouveaux produits ainsi obtenus et leur utilisation comme produits a activites neuroleptique et analgesique |
FR7538466A Granted FR2287226A1 (fr) | 1974-04-18 | 1975-12-16 | Procede de production de composes de butyrophenone a groupe 4-oxo-1-phenyl-1,3,8-triazaspiro (4,5) decane, nouveaux produits ainsi obtenus et leur utilisation comme produits a activites neuroleptique et analgesique |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7511865A Expired FR2267776B1 (fr) | 1974-04-18 | 1975-04-16 | |
FR7538465A Granted FR2287225A1 (fr) | 1974-04-18 | 1975-12-16 | Procede de production de composes de butyrophenone a groupes 2-oxo-benzimidazol-1-yl-4'-piperidino ou 2-oxo-benzimidazol-1-yl-4'-tetrahydropyridino, nouveaux produits ainsi obtenus et leur utilisation comme produits a activites neuroleptique et analgesique |
Country Status (8)
Country | Link |
---|---|
US (2) | US4039670A (fr) |
JP (1) | JPS595587B2 (fr) |
BE (1) | BE828023A (fr) |
DE (1) | DE2517278A1 (fr) |
FR (3) | FR2267776B1 (fr) |
GB (1) | GB1453552A (fr) |
NL (1) | NL7504601A (fr) |
SE (1) | SE7504382L (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5817461B2 (ja) * | 1977-06-03 | 1983-04-07 | 住友化学工業株式会社 | ブチロフェノン誘導体の製造法 |
US4242347A (en) * | 1979-06-18 | 1980-12-30 | Ciba-Geigy Corporation | Hypotensive indolylalkylpiperidyl guanidines and isoureas |
EP0661266A1 (fr) * | 1993-12-27 | 1995-07-05 | Toa Eiyo Ltd. | Composés cycliques aminés substitués comme 5HT2 antagonistes |
JP3989247B2 (ja) * | 1999-12-06 | 2007-10-10 | ユーロ−セルティーク エス.エイ. | ノシセプチン受容体親和性を有するトリアゾスピロ化合物 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB895309A (en) * | 1959-11-18 | 1962-05-02 | Res Lab Dr C Janssen Nv | Pyrrolidine and piperidine derivatives |
US3080372A (en) * | 1960-03-25 | 1963-03-05 | Res Lab Dr C Janssen | 1-aroylalkyl-4-arylpiperidine derivatives |
FR1347960A (fr) * | 1961-12-22 | 1964-01-04 | Res Lab Dr C Janssen Nv | Procédé de préparation de composés du type des 1-(1-aroylpropyl-4-pipéridyl)-2-benzimidazolinones |
US3238216A (en) * | 1963-06-20 | 1966-03-01 | Res Lab Dr C Janssen N V | Substituted 1, 3, 8-triaza-spiro (4, 5) decanes |
US3408356A (en) * | 1965-08-31 | 1968-10-29 | Squibb & Sons Inc | Long chain esters of 4'-fluoro-4-[4-hydroxy-4-(alpha, alpha, alpha-trifluorotolyl)piperi-dino]butyrophenone and the like |
GB1141664A (en) * | 1965-12-08 | 1969-01-29 | Janssen Pharmaceutica Nv | Piperidine derivatives |
US3476762A (en) * | 1966-12-27 | 1969-11-04 | Aldrich Chem Co Inc | 4' - dimethylamino - 4 - (4 - hydroxy-4-phenyl piperidino)butyrophenones and 4 - (4-phenyl-4-hydroxy - piperidino)-1,1-ethylenedioxy - 1 - (4 - dimethylaminophenyl)butanes |
US3679666A (en) * | 1969-04-03 | 1972-07-25 | Hoffmann La Roche | 4-(4-hydroxypiperidino)-4'-fluorobutyrophenones |
DK131147B (da) * | 1969-10-27 | 1975-06-02 | Sumitomo Chemical Co | Fremgangsmåde til fremstilling af butyrophenonderivater eller syreadditionssalte deraf. |
US3936468A (en) * | 1969-10-27 | 1976-02-03 | Sumitomo Chemical Company, Ltd. | Phenylbutanol derivatives |
DE2019820A1 (de) * | 1970-04-23 | 1971-11-18 | Yoshitomi Pharmaceutical | Heterocyclische Verbindungen und Verfahren zu deren Herstellung |
US3850935A (en) * | 1971-10-16 | 1974-11-26 | Sumitomo Chemical Co | Process for producing piperidine derivatives by degrading quaternary piperidinium salts |
JPS5755714B2 (fr) * | 1972-03-18 | 1982-11-25 | ||
SE419441B (sv) * | 1972-03-18 | 1981-08-03 | Sumitomo Chemical Co | Forfarande for framstellning av butyrofenonderivat |
JPS4914476A (fr) * | 1972-06-07 | 1974-02-07 | ||
US3922266A (en) * | 1972-06-28 | 1975-11-25 | Sumitomo Chemical Co | Aryl ketones and production thereof |
-
1974
- 1974-04-18 JP JP49044181A patent/JPS595587B2/ja not_active Expired
-
1975
- 1975-04-16 SE SE7504382A patent/SE7504382L/xx unknown
- 1975-04-16 FR FR7511865A patent/FR2267776B1/fr not_active Expired
- 1975-04-17 GB GB1589975A patent/GB1453552A/en not_active Expired
- 1975-04-17 NL NL7504601A patent/NL7504601A/xx not_active Application Discontinuation
- 1975-04-17 BE BE155474A patent/BE828023A/fr unknown
- 1975-04-17 US US05/568,819 patent/US4039670A/en not_active Expired - Lifetime
- 1975-04-18 DE DE19752517278 patent/DE2517278A1/de not_active Withdrawn
- 1975-12-16 FR FR7538465A patent/FR2287225A1/fr active Granted
- 1975-12-16 FR FR7538466A patent/FR2287226A1/fr active Granted
-
1977
- 1977-05-09 US US05/795,145 patent/US4303663A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
FR2287226B1 (fr) | 1980-06-06 |
JPS595587B2 (ja) | 1984-02-06 |
US4303663A (en) | 1981-12-01 |
US4039670A (en) | 1977-08-02 |
FR2287225B1 (fr) | 1979-09-21 |
FR2287225A1 (fr) | 1976-05-07 |
GB1453552A (en) | 1976-10-27 |
FR2267776B1 (fr) | 1978-11-17 |
SE7504382L (sv) | 1975-10-20 |
BE828023A (fr) | 1975-10-17 |
DE2517278A1 (de) | 1975-11-06 |
FR2267776A1 (fr) | 1975-11-14 |
JPS50140464A (fr) | 1975-11-11 |
NL7504601A (nl) | 1975-10-21 |
AU8012575A (en) | 1976-10-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |