FR2287225A1 - Procede de production de composes de butyrophenone a groupes 2-oxo-benzimidazol-1-yl-4'-piperidino ou 2-oxo-benzimidazol-1-yl-4'-tetrahydropyridino, nouveaux produits ainsi obtenus et leur utilisation comme produits a activites neuroleptique et analgesique - Google Patents

Procede de production de composes de butyrophenone a groupes 2-oxo-benzimidazol-1-yl-4'-piperidino ou 2-oxo-benzimidazol-1-yl-4'-tetrahydropyridino, nouveaux produits ainsi obtenus et leur utilisation comme produits a activites neuroleptique et analgesique

Info

Publication number
FR2287225A1
FR2287225A1 FR7538465A FR7538465A FR2287225A1 FR 2287225 A1 FR2287225 A1 FR 2287225A1 FR 7538465 A FR7538465 A FR 7538465A FR 7538465 A FR7538465 A FR 7538465A FR 2287225 A1 FR2287225 A1 FR 2287225A1
Authority
FR
France
Prior art keywords
benzimidazol
oxo
tetrahydropyridino
neuroleptic
piperidino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7538465A
Other languages
English (en)
Other versions
FR2287225B1 (fr
Inventor
Kikuo Sasajima
Keiichi Ono
Masaru Nakao
Hisao Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Publication of FR2287225A1 publication Critical patent/FR2287225A1/fr
Application granted granted Critical
Publication of FR2287225B1 publication Critical patent/FR2287225B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FR7538465A 1974-04-18 1975-12-16 Procede de production de composes de butyrophenone a groupes 2-oxo-benzimidazol-1-yl-4'-piperidino ou 2-oxo-benzimidazol-1-yl-4'-tetrahydropyridino, nouveaux produits ainsi obtenus et leur utilisation comme produits a activites neuroleptique et analgesique Granted FR2287225A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP49044181A JPS595587B2 (ja) 1974-04-18 1974-04-18 シンキナブチロフエノンユウドウタイ オヨビ ソノエン ノ セイホウ

Publications (2)

Publication Number Publication Date
FR2287225A1 true FR2287225A1 (fr) 1976-05-07
FR2287225B1 FR2287225B1 (fr) 1979-09-21

Family

ID=12684393

Family Applications (3)

Application Number Title Priority Date Filing Date
FR7511865A Expired FR2267776B1 (fr) 1974-04-18 1975-04-16
FR7538465A Granted FR2287225A1 (fr) 1974-04-18 1975-12-16 Procede de production de composes de butyrophenone a groupes 2-oxo-benzimidazol-1-yl-4'-piperidino ou 2-oxo-benzimidazol-1-yl-4'-tetrahydropyridino, nouveaux produits ainsi obtenus et leur utilisation comme produits a activites neuroleptique et analgesique
FR7538466A Granted FR2287226A1 (fr) 1974-04-18 1975-12-16 Procede de production de composes de butyrophenone a groupe 4-oxo-1-phenyl-1,3,8-triazaspiro (4,5) decane, nouveaux produits ainsi obtenus et leur utilisation comme produits a activites neuroleptique et analgesique

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR7511865A Expired FR2267776B1 (fr) 1974-04-18 1975-04-16

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR7538466A Granted FR2287226A1 (fr) 1974-04-18 1975-12-16 Procede de production de composes de butyrophenone a groupe 4-oxo-1-phenyl-1,3,8-triazaspiro (4,5) decane, nouveaux produits ainsi obtenus et leur utilisation comme produits a activites neuroleptique et analgesique

Country Status (8)

Country Link
US (2) US4039670A (fr)
JP (1) JPS595587B2 (fr)
BE (1) BE828023A (fr)
DE (1) DE2517278A1 (fr)
FR (3) FR2267776B1 (fr)
GB (1) GB1453552A (fr)
NL (1) NL7504601A (fr)
SE (1) SE7504382L (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5817461B2 (ja) * 1977-06-03 1983-04-07 住友化学工業株式会社 ブチロフェノン誘導体の製造法
US4242347A (en) * 1979-06-18 1980-12-30 Ciba-Geigy Corporation Hypotensive indolylalkylpiperidyl guanidines and isoureas
EP0661266A1 (fr) * 1993-12-27 1995-07-05 Toa Eiyo Ltd. Composés cycliques aminés substitués comme 5HT2 antagonistes
WO2001039723A2 (fr) * 1999-12-06 2001-06-07 Euro-Celtique, S.A. Composes triazospiro presentant une affinite pour le recepteur de la nociceptine

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1347960A (fr) * 1961-12-22 1964-01-04 Res Lab Dr C Janssen Nv Procédé de préparation de composés du type des 1-(1-aroylpropyl-4-pipéridyl)-2-benzimidazolinones
FR2070166A1 (fr) * 1969-10-27 1971-09-10 Sumitomo Chemical Co
FR2183683A1 (fr) * 1972-03-18 1973-12-21 Sumitomo Chemical Co

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB895309A (en) * 1959-11-18 1962-05-02 Res Lab Dr C Janssen Nv Pyrrolidine and piperidine derivatives
US3080372A (en) * 1960-03-25 1963-03-05 Res Lab Dr C Janssen 1-aroylalkyl-4-arylpiperidine derivatives
US3238216A (en) * 1963-06-20 1966-03-01 Res Lab Dr C Janssen N V Substituted 1, 3, 8-triaza-spiro (4, 5) decanes
US3408356A (en) * 1965-08-31 1968-10-29 Squibb & Sons Inc Long chain esters of 4'-fluoro-4-[4-hydroxy-4-(alpha, alpha, alpha-trifluorotolyl)piperi-dino]butyrophenone and the like
GB1141664A (en) * 1965-12-08 1969-01-29 Janssen Pharmaceutica Nv Piperidine derivatives
US3476762A (en) * 1966-12-27 1969-11-04 Aldrich Chem Co Inc 4' - dimethylamino - 4 - (4 - hydroxy-4-phenyl piperidino)butyrophenones and 4 - (4-phenyl-4-hydroxy - piperidino)-1,1-ethylenedioxy - 1 - (4 - dimethylaminophenyl)butanes
US3679666A (en) * 1969-04-03 1972-07-25 Hoffmann La Roche 4-(4-hydroxypiperidino)-4'-fluorobutyrophenones
US3936468A (en) * 1969-10-27 1976-02-03 Sumitomo Chemical Company, Ltd. Phenylbutanol derivatives
DE2019820A1 (de) * 1970-04-23 1971-11-18 Yoshitomi Pharmaceutical Heterocyclische Verbindungen und Verfahren zu deren Herstellung
US3850935A (en) * 1971-10-16 1974-11-26 Sumitomo Chemical Co Process for producing piperidine derivatives by degrading quaternary piperidinium salts
JPS5755714B2 (fr) * 1972-03-18 1982-11-25
JPS4914476A (fr) * 1972-06-07 1974-02-07
US3922266A (en) * 1972-06-28 1975-11-25 Sumitomo Chemical Co Aryl ketones and production thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1347960A (fr) * 1961-12-22 1964-01-04 Res Lab Dr C Janssen Nv Procédé de préparation de composés du type des 1-(1-aroylpropyl-4-pipéridyl)-2-benzimidazolinones
FR2070166A1 (fr) * 1969-10-27 1971-09-10 Sumitomo Chemical Co
FR2183683A1 (fr) * 1972-03-18 1973-12-21 Sumitomo Chemical Co

Also Published As

Publication number Publication date
FR2287225B1 (fr) 1979-09-21
NL7504601A (nl) 1975-10-21
GB1453552A (en) 1976-10-27
FR2287226B1 (fr) 1980-06-06
AU8012575A (en) 1976-10-21
DE2517278A1 (de) 1975-11-06
BE828023A (fr) 1975-10-17
FR2267776B1 (fr) 1978-11-17
SE7504382L (sv) 1975-10-20
JPS50140464A (fr) 1975-11-11
US4303663A (en) 1981-12-01
FR2267776A1 (fr) 1975-11-14
FR2287226A1 (fr) 1976-05-07
JPS595587B2 (ja) 1984-02-06
US4039670A (en) 1977-08-02

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