FR2269938A2 - 5-Hydroxymethyl-3,4-diphenyl-1,2,4-triazoles - with anticholinergic, bronchodilator, antidepressant, analgesic, vasodilator activity, etc. - Google Patents
5-Hydroxymethyl-3,4-diphenyl-1,2,4-triazoles - with anticholinergic, bronchodilator, antidepressant, analgesic, vasodilator activity, etc.Info
- Publication number
- FR2269938A2 FR2269938A2 FR7415855A FR7415855A FR2269938A2 FR 2269938 A2 FR2269938 A2 FR 2269938A2 FR 7415855 A FR7415855 A FR 7415855A FR 7415855 A FR7415855 A FR 7415855A FR 2269938 A2 FR2269938 A2 FR 2269938A2
- Authority
- FR
- France
- Prior art keywords
- hydroxymethyl
- diphenyl
- bronchodilator
- anticholinergic
- antidepressant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 analgesic Substances 0.000 title abstract 2
- QFLSXOVPLRTIBH-UHFFFAOYSA-N (4,5-diphenyl-1,2,4-triazol-3-yl)methanol Chemical class C=1C=CC=CC=1N1C(CO)=NN=C1C1=CC=CC=C1 QFLSXOVPLRTIBH-UHFFFAOYSA-N 0.000 title 1
- 230000000202 analgesic effect Effects 0.000 title 1
- 230000001078 anti-cholinergic effect Effects 0.000 title 1
- 230000001430 anti-depressive effect Effects 0.000 title 1
- 239000000935 antidepressant agent Substances 0.000 title 1
- 229940005513 antidepressants Drugs 0.000 title 1
- 229940124630 bronchodilator Drugs 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 229940124549 vasodilator Drugs 0.000 title 1
- 239000003071 vasodilator agent Substances 0.000 title 1
- XIJVQVGUXRXZBT-UHFFFAOYSA-N (3,4-diphenyl-3H-1,2,4-triazin-5-yl)methanol Chemical class OCC=1N(C(N=NC=1)C1=CC=CC=C1)C1=CC=CC=C1 XIJVQVGUXRXZBT-UHFFFAOYSA-N 0.000 abstract 1
- 206010017999 Gastrointestinal pain Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 206010065390 Inflammatory pain Diseases 0.000 abstract 1
- 206010030113 Oedema Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 208000008469 Peptic Ulcer Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 230000036543 hypotension Effects 0.000 abstract 1
- 208000011906 peptic ulcer disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7415855A FR2269938A2 (en) | 1974-05-08 | 1974-05-08 | 5-Hydroxymethyl-3,4-diphenyl-1,2,4-triazoles - with anticholinergic, bronchodilator, antidepressant, analgesic, vasodilator activity, etc. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7415855A FR2269938A2 (en) | 1974-05-08 | 1974-05-08 | 5-Hydroxymethyl-3,4-diphenyl-1,2,4-triazoles - with anticholinergic, bronchodilator, antidepressant, analgesic, vasodilator activity, etc. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2269938A2 true FR2269938A2 (en) | 1975-12-05 |
| FR2269938B2 FR2269938B2 (esLanguage) | 1978-02-03 |
Family
ID=9138579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7415855A Granted FR2269938A2 (en) | 1974-05-08 | 1974-05-08 | 5-Hydroxymethyl-3,4-diphenyl-1,2,4-triazoles - with anticholinergic, bronchodilator, antidepressant, analgesic, vasodilator activity, etc. |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2269938A2 (esLanguage) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3133185A1 (de) * | 1980-08-22 | 1982-04-08 | Roussel-Uclaf, 75007 Paris | "4h-1,2,4-triazolderivate, verfahren zu deren herstellung und deren verwendung" |
| FR2570699A1 (fr) * | 1984-09-24 | 1986-03-28 | Roussel Uclaf | Nouveau procede de preparation de derives du 4h-1,2,4-triazole, nouveaux triazoles ainsi obtenus, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
| EP0335381A1 (de) * | 1988-03-30 | 1989-10-04 | Boehringer Ingelheim Kg | Neue 2,3,4-substituierte Imidazole und 3,4,5-substituierte 1,2,4-Triazole, ihre Herstellung und Verwendung |
| EP0335144A1 (de) * | 1988-03-12 | 1989-10-04 | Boehringer Ingelheim Kg | Neue 3,4,5-substituierte 4H-1,2,4-Triazole, ihre Herstellung und Verwendung |
| WO1991002731A1 (de) * | 1989-08-19 | 1991-03-07 | Boehringer Ingelheim Kg | Substituierte n-heterocyclen, ihre herstellung und verwendung |
| WO2003066050A1 (en) * | 2002-02-07 | 2003-08-14 | The Curators Of The University Of Missouri | Opioid receptor active 4-(3-hydroxyphenyl) or 4-(3-alkoxyphenyl)-1,2,4-triazole compounds |
-
1974
- 1974-05-08 FR FR7415855A patent/FR2269938A2/fr active Granted
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3133185A1 (de) * | 1980-08-22 | 1982-04-08 | Roussel-Uclaf, 75007 Paris | "4h-1,2,4-triazolderivate, verfahren zu deren herstellung und deren verwendung" |
| FR2570699A1 (fr) * | 1984-09-24 | 1986-03-28 | Roussel Uclaf | Nouveau procede de preparation de derives du 4h-1,2,4-triazole, nouveaux triazoles ainsi obtenus, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
| EP0176444A1 (fr) * | 1984-09-24 | 1986-04-02 | Roussel-Uclaf | Nouveau procédé de préparation de dérivés du 4 H-1,2-4-triazole, nouveaux triazoles ainsi obtenus, leur applicication comme médicaments et les compositions pharmaceutiques les renfermant |
| EP0335144A1 (de) * | 1988-03-12 | 1989-10-04 | Boehringer Ingelheim Kg | Neue 3,4,5-substituierte 4H-1,2,4-Triazole, ihre Herstellung und Verwendung |
| FR2629457A1 (fr) * | 1988-03-30 | 1989-10-06 | Boehringer Ingelheim Kg | Imidazoles substitues en positions 2, 3, 4, et 1, 2, 4-triazoles substitues en positions 3, 4, 5, leur preparation et leur utilisation |
| WO1989009212A1 (fr) * | 1988-03-30 | 1989-10-05 | Boehringer Ingelheim Kg | Nouveaux imidazoles 2,3,4-substitues et 1,2,4-triazoles 3,4,5-substitues; preparation et application |
| EP0335381A1 (de) * | 1988-03-30 | 1989-10-04 | Boehringer Ingelheim Kg | Neue 2,3,4-substituierte Imidazole und 3,4,5-substituierte 1,2,4-Triazole, ihre Herstellung und Verwendung |
| WO1991002731A1 (de) * | 1989-08-19 | 1991-03-07 | Boehringer Ingelheim Kg | Substituierte n-heterocyclen, ihre herstellung und verwendung |
| GR900100619A (el) * | 1989-08-19 | 1991-12-30 | Boehringer Ingelheim Kg | Υποκατεστημενα ν-ετεροκυκλικα,παραγωγη και χρησις αυτων. |
| WO2003066050A1 (en) * | 2002-02-07 | 2003-08-14 | The Curators Of The University Of Missouri | Opioid receptor active 4-(3-hydroxyphenyl) or 4-(3-alkoxyphenyl)-1,2,4-triazole compounds |
| US7045520B2 (en) | 2002-02-07 | 2006-05-16 | The Curators Of The University Of Missouri | Opioid receptor active compounds |
| US7294720B2 (en) | 2002-02-07 | 2007-11-13 | The Curators Of The University Of Missouri | Opioid receptor active compounds |
| US7776898B2 (en) | 2002-02-07 | 2010-08-17 | The Curators Of The University Of Missouri | Opioid receptor active compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2269938B2 (esLanguage) | 1978-02-03 |
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