FR2264539A1 - Metformin orotate - hypoglycemic, hypocholesterolemic and uricosuric agent - Google Patents
Metformin orotate - hypoglycemic, hypocholesterolemic and uricosuric agentInfo
- Publication number
- FR2264539A1 FR2264539A1 FR7409962A FR7409962A FR2264539A1 FR 2264539 A1 FR2264539 A1 FR 2264539A1 FR 7409962 A FR7409962 A FR 7409962A FR 7409962 A FR7409962 A FR 7409962A FR 2264539 A1 FR2264539 A1 FR 2264539A1
- Authority
- FR
- France
- Prior art keywords
- metformin
- hypoglycemic
- gout
- hypocholesterolemic
- orotate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002218 hypoglycaemic effect Effects 0.000 title abstract 3
- KIAVTTZIWJZMIP-UHFFFAOYSA-N 3-(diaminomethylidene)-1,1-dimethylguanidine;2,4-dioxo-1h-pyrimidine-6-carboxylic acid Chemical compound CN(C)C(=N)N=C(N)N.OC(=O)C1=CC(=O)NC(=O)N1 KIAVTTZIWJZMIP-UHFFFAOYSA-N 0.000 title 1
- 229940116731 Uricosuric agent Drugs 0.000 title 1
- 239000003529 anticholesteremic agent Substances 0.000 title 1
- 239000003472 antidiabetic agent Substances 0.000 title 1
- 230000000871 hypocholesterolemic effect Effects 0.000 title 1
- 239000003383 uricosuric agent Substances 0.000 title 1
- 201000005569 Gout Diseases 0.000 abstract 3
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 abstract 2
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 abstract 2
- PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 abstract 2
- 229940116269 uric acid Drugs 0.000 abstract 2
- 208000013016 Hypoglycemia Diseases 0.000 abstract 1
- 208000015924 Lithiasis Diseases 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 230000037356 lipid metabolism Effects 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 abstract 1
- 229960003105 metformin Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229960005010 orotic acid Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
- C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7409962A FR2264539A1 (en) | 1974-03-22 | 1974-03-22 | Metformin orotate - hypoglycemic, hypocholesterolemic and uricosuric agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7409962A FR2264539A1 (en) | 1974-03-22 | 1974-03-22 | Metformin orotate - hypoglycemic, hypocholesterolemic and uricosuric agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2264539A1 true FR2264539A1 (en) | 1975-10-17 |
| FR2264539B1 FR2264539B1 (enExample) | 1977-11-04 |
Family
ID=9136731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7409962A Granted FR2264539A1 (en) | 1974-03-22 | 1974-03-22 | Metformin orotate - hypoglycemic, hypocholesterolemic and uricosuric agent |
Country Status (1)
| Country | Link |
|---|---|
| FR (1) | FR2264539A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2796551A1 (fr) * | 1999-07-23 | 2001-01-26 | Lipha | Nouveaux sels de metformine, leur procede d'obtention et les compositions pharmaceutiques en renfermant |
| FR2796940A1 (fr) * | 1999-07-26 | 2001-02-02 | Lipha | Nouveaux sels de metformine, leur procede d'obtention et les compositions pharmaceutiques en renfermant |
-
1974
- 1974-03-22 FR FR7409962A patent/FR2264539A1/fr active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2796551A1 (fr) * | 1999-07-23 | 2001-01-26 | Lipha | Nouveaux sels de metformine, leur procede d'obtention et les compositions pharmaceutiques en renfermant |
| FR2796940A1 (fr) * | 1999-07-26 | 2001-02-02 | Lipha | Nouveaux sels de metformine, leur procede d'obtention et les compositions pharmaceutiques en renfermant |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2264539B1 (enExample) | 1977-11-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IE882583L (en) | Treatment of wounds | |
| DK1586314T3 (da) | Nateglinide tablet sammensætning | |
| ATE31625T1 (de) | Pharmazeutisches mittel zur behandlung des diabetes mellitus. | |
| JPS56104815A (en) | Remedy for peripheral orthostatic hypotension | |
| KR910000158A (ko) | 의약용 화합물 및 그것의 사용방법 | |
| KR880003626A (ko) | 레트로비루스로 감염된 환자의 치료에 있어서의 2',3'-디디옥시사이티딘-2'-엔(2',3'-디디옥시-2',3'-디디하이드로사이티딘)의 사용법 | |
| GB1386150A (en) | 6-acylaminophenyl-4,5-dihydropyridazones | |
| HU903092D0 (en) | Process for the preparation of buten-carboxylic acid derivatives and pharmaceutical compositions containing such compounds | |
| EP0270046A3 (en) | Pharmaceutical composition for treatment of cataract | |
| ATE85521T1 (de) | Verwendung von acetyl-l-carnitin zur herstellung eines arzneimittels zur therapeutischen behandlung von schockzustaenden. | |
| JPS54148090A (en) | Peroral cholesterol-depressant | |
| FR2275199A1 (fr) | (chloro-4 phenoxy) isobutyrate de dimethylbiguanide, son procede de preparation et medicaments contenant ce produit comme principe actif | |
| RU2003338C1 (ru) | Средство, обладающее желчегонным действием | |
| JPS57130545A (en) | Urea adsorbing agent | |
| JPS5675428A (en) | Hypoglycemic agent containing procainamide hydrochloride | |
| SU459228A1 (ru) | Лекарственное средство | |
| USD236268S (en) | Best available copy | |
| NL7703682A (en) | Antiinflammatory, analgesic alclofenac lysine salt - with improved bio-availability and suitable for admin. by injection | |
| USD205791S (en) | Instrument face for gyroscopic instruments | |
| JPS56103114A (en) | Drug for osteoporosis comprising 24r- hydroxycholecalciferol | |
| JPS5759813A (en) | Alpha-glucosidase inhibitor | |
| JPS5398632A (en) | Ball screw type steering apparatus | |
| ATE4023T1 (de) | Biflavanon enthaltende arzneimittel. | |
| JPS5549381A (en) | 1-(3-hydroxypropyl)-3, 7-dimethylxanthine and its preparation | |
| Peto | The Biology of Cancer—A New Approach |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |