FR2264539A1 - Metformin orotate - hypoglycemic, hypocholesterolemic and uricosuric agent - Google Patents

Metformin orotate - hypoglycemic, hypocholesterolemic and uricosuric agent

Info

Publication number
FR2264539A1
FR2264539A1 FR7409962A FR7409962A FR2264539A1 FR 2264539 A1 FR2264539 A1 FR 2264539A1 FR 7409962 A FR7409962 A FR 7409962A FR 7409962 A FR7409962 A FR 7409962A FR 2264539 A1 FR2264539 A1 FR 2264539A1
Authority
FR
France
Prior art keywords
metformin
hypoglycemic
gout
hypocholesterolemic
orotate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7409962A
Other languages
French (fr)
Other versions
FR2264539B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EXPL MARQUES BREVETS ET
Original Assignee
EXPL MARQUES BREVETS ET
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EXPL MARQUES BREVETS ET filed Critical EXPL MARQUES BREVETS ET
Priority to FR7409962A priority Critical patent/FR2264539A1/en
Publication of FR2264539A1 publication Critical patent/FR2264539A1/en
Application granted granted Critical
Publication of FR2264539B1 publication Critical patent/FR2264539B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C07C279/26—X and Y being nitrogen atoms, i.e. biguanides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Cpds. of formula (I): where n = 1 or a whole number >1, is a hypoglycemic which allows regulation of sugar levels without risk of hypoglycemia in diabetics. (I) reduces the uric acid level and is hypocholetsterolemic. It is used to prevent lipid metabolism and uric acid metabolism troubles in diabetics, to treat and prevent acute or chronic gout and complications such as uratic lithiasis, renal gout and articular forms of gout. The cpd. (I) has superior properties to a mixture of orotic acid and metformin and has low toxicity e.g. in Swiss mice oral LD50=1.30g/kg, i.p. LD50=0.55 g/kg.
FR7409962A 1974-03-22 1974-03-22 Metformin orotate - hypoglycemic, hypocholesterolemic and uricosuric agent Granted FR2264539A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7409962A FR2264539A1 (en) 1974-03-22 1974-03-22 Metformin orotate - hypoglycemic, hypocholesterolemic and uricosuric agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7409962A FR2264539A1 (en) 1974-03-22 1974-03-22 Metformin orotate - hypoglycemic, hypocholesterolemic and uricosuric agent

Publications (2)

Publication Number Publication Date
FR2264539A1 true FR2264539A1 (en) 1975-10-17
FR2264539B1 FR2264539B1 (en) 1977-11-04

Family

ID=9136731

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7409962A Granted FR2264539A1 (en) 1974-03-22 1974-03-22 Metformin orotate - hypoglycemic, hypocholesterolemic and uricosuric agent

Country Status (1)

Country Link
FR (1) FR2264539A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2796551A1 (en) * 1999-07-23 2001-01-26 Lipha New metformin salts, e.g. the thioctate, hippurate or alginate, having improved passage through the digestive barrier and improved resorption, useful for treating diabetes
FR2796940A1 (en) * 1999-07-26 2001-02-02 Lipha Metformin salts active in alleviating diabetic metabolic syndromes, such as protein metabolic disorders, hypertension, inflamed joints, obesity and increase in serum triglycerides

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2796551A1 (en) * 1999-07-23 2001-01-26 Lipha New metformin salts, e.g. the thioctate, hippurate or alginate, having improved passage through the digestive barrier and improved resorption, useful for treating diabetes
FR2796940A1 (en) * 1999-07-26 2001-02-02 Lipha Metformin salts active in alleviating diabetic metabolic syndromes, such as protein metabolic disorders, hypertension, inflamed joints, obesity and increase in serum triglycerides

Also Published As

Publication number Publication date
FR2264539B1 (en) 1977-11-04

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Legal Events

Date Code Title Description
ST Notification of lapse