FR2258846A1 - Bis((N-hydroxy alkyl)-amino alkyl thio)alkane and derivs - as agents preventing blood platelet aggregation - Google Patents

Bis((N-hydroxy alkyl)-amino alkyl thio)alkane and derivs - as agents preventing blood platelet aggregation

Info

Publication number
FR2258846A1
FR2258846A1 FR7502307A FR7502307A FR2258846A1 FR 2258846 A1 FR2258846 A1 FR 2258846A1 FR 7502307 A FR7502307 A FR 7502307A FR 7502307 A FR7502307 A FR 7502307A FR 2258846 A1 FR2258846 A1 FR 2258846A1
Authority
FR
France
Prior art keywords
bis
platelet aggregation
derivs
alkane
blood platelet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7502307A
Other languages
French (fr)
Other versions
FR2258846B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon France SAS
Original Assignee
Laboratoire L Lafon SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB366474A external-priority patent/GB1490983A/en
Application filed by Laboratoire L Lafon SA filed Critical Laboratoire L Lafon SA
Publication of FR2258846A1 publication Critical patent/FR2258846A1/en
Priority to CH1204875A priority Critical patent/CH609024A5/en
Priority to IE207075A priority patent/IE42609B1/en
Priority to CA236,205A priority patent/CA1064504A/en
Priority to DE19752560602 priority patent/DE2560602C2/en
Priority to DE19752543179 priority patent/DE2543179A1/en
Priority to NL7511452A priority patent/NL176776C/en
Priority to DK437075A priority patent/DK146336C/en
Priority to ES444013A priority patent/ES444013A1/en
Application granted granted Critical
Publication of FR2258846B1 publication Critical patent/FR2258846B1/fr
Priority to DK31680A priority patent/DK152206C/en
Priority to DK31580A priority patent/DK159966C/en
Priority to DK31780A priority patent/DK31780A/en
Priority to NLAANVRAGE8302611,A priority patent/NL178418C/en
Priority to NLAANVRAGE8302613,A priority patent/NL178964C/en
Priority to NLAANVRAGE8302612,A priority patent/NL178316C/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/42—Y being a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Bis (N-hydroxy-alkyl)-Aminoalkylthio -alkanes (I) of formula- B-NR-A-SOx-(CH2)n-SOx-A-NR-B (I) (where n is 5-15; x is 0,1 or 2; A is 2-6C alkylene; B is hydroxyalkyl, dihydroxyalkyl or acyloxyalkyl; R is H, alkyl, acyl, B, alkylsulphonic or alkylsulphonate), prevents blood platelet aggregation.
FR7502307A 1974-01-25 1975-01-24 Bis((N-hydroxy alkyl)-amino alkyl thio)alkane and derivs - as agents preventing blood platelet aggregation Granted FR2258846A1 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
CH1204875A CH609024A5 (en) 1974-09-30 1975-09-17 Process for the preparation of new sulphur-containing diaryl and oxygen-containing diaryl compounds
IE207075A IE42609B1 (en) 1974-09-30 1975-09-22 Sulphur- and oxygen-containing diaryl compounds
CA236,205A CA1064504A (en) 1974-09-30 1975-09-23 Sulphur- and oxygen-containing diaryl compounds
DE19752543179 DE2543179A1 (en) 1974-09-30 1975-09-27 Diphenyl (thio)ethers against circulatory disorders - prepd by reacting a diphenyl deriv with a halogen deriv, then opt hydrolysis
DE19752560602 DE2560602C2 (en) 1974-09-30 1975-09-27 Oxygenated diarylamidines
NL7511452A NL176776C (en) 1974-09-30 1975-09-29 METHOD FOR PREPARING MEDICINES WITH BLOOD PLATE AGGREGATION INHIBITING AND SERUM LIPID RESP. SERUM CHOLESTEROL MIRROR LOWERING ACTIVITY, AND METHOD FOR PREPARING APPROPRIATE MEDICINE COMPOUNDS.
DK437075A DK146336C (en) 1974-09-30 1975-09-29 ANALOGY PROCEDURE FOR THE PREPARATION OF ACID ADDITION SALTS OF SULFUL DIARYL COMPOUNDS
ES444013A ES444013A1 (en) 1975-01-14 1975-12-31 A procedure for preparation of a sulfurated and/or oxygenated diarylic compound. (Machine-translation by Google Translate, not legally binding)
DK31680A DK152206C (en) 1974-09-30 1980-01-25 METHOD OF ANALOGUE FOR THE PREPARATION OF SULFUR AND / OR OXYGEN-DIARYL COMPOUNDS OR ACID ADDITION SALTS
DK31780A DK31780A (en) 1974-09-30 1980-01-25 METHOD OF ANALOGUE FOR THE PREPARATION OF OXYGEN-CONTAINED DIARYL COMPOUNDS AND ACID ADDITION SALTS
DK31580A DK159966C (en) 1974-09-30 1980-01-25 ANALOGY PROCEDURE FOR THE PREPARATION OF OXYGEN-CONTAINED DIARYL COMPOUNDS
NLAANVRAGE8302612,A NL178316C (en) 1974-09-30 1983-07-21 METHOD FOR PREPARING MEDICINES WITH GOOD INFLUENCE ON BLOOD CIRCUMSTICS AND METHOD FOR PREPARING MEDICINAL COMPOSITIONS SUITABLE THEREFOR.
NLAANVRAGE8302611,A NL178418C (en) 1974-09-30 1983-07-21 METHOD FOR PREPARING PHENYL ETHERS CONTAINING MEDICINES WITH FAVORABLE INFLUENCE ON BLOOD CIRCULATION AND SUITABLE COMPOUNDS
NLAANVRAGE8302613,A NL178964C (en) 1974-09-30 1983-07-21 METHOD FOR PREPARING MEDICINES WITH GOOD INFLUENCE ON BLOOD CIRCUMSTICS AND METHOD FOR PREPARING MEDICINAL COMPOSITIONS SUITABLE THEREFOR.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB366474A GB1490983A (en) 1974-01-25 1974-01-25 Bis((n-hydroxyalkyl)-aminoalkylthio)-alkanes and derivatives thereof
GB4789074 1974-11-05

Publications (2)

Publication Number Publication Date
FR2258846A1 true FR2258846A1 (en) 1975-08-22
FR2258846B1 FR2258846B1 (en) 1978-06-30

Family

ID=26238500

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7502307A Granted FR2258846A1 (en) 1974-01-25 1975-01-24 Bis((N-hydroxy alkyl)-amino alkyl thio)alkane and derivs - as agents preventing blood platelet aggregation

Country Status (1)

Country Link
FR (1) FR2258846A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2285861A1 (en) * 1974-09-30 1976-04-23 Lafon Labor DIARYL SULFUR AND DIARYL OXYGEN COMPOUNDS
DE2715184A1 (en) 1976-04-06 1977-10-27 Lafon Labor DIARYLAETHERS AND THIOAETHERS AND MEDICINAL PRODUCTS CONTAINING THESE
FR2384754A1 (en) * 1977-03-21 1978-10-20 Lafon Labor Cardiovascular active 1,3-di:mercapto:benzene cpds. - useful as hypolipidaemic agents, platelet aggregation inhibitors etc.

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2285861A1 (en) * 1974-09-30 1976-04-23 Lafon Labor DIARYL SULFUR AND DIARYL OXYGEN COMPOUNDS
DE2715184A1 (en) 1976-04-06 1977-10-27 Lafon Labor DIARYLAETHERS AND THIOAETHERS AND MEDICINAL PRODUCTS CONTAINING THESE
FR2384754A1 (en) * 1977-03-21 1978-10-20 Lafon Labor Cardiovascular active 1,3-di:mercapto:benzene cpds. - useful as hypolipidaemic agents, platelet aggregation inhibitors etc.

Also Published As

Publication number Publication date
FR2258846B1 (en) 1978-06-30

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