FR2253023A1 - - Google Patents
Info
- Publication number
- FR2253023A1 FR2253023A1 FR7439017A FR7439017A FR2253023A1 FR 2253023 A1 FR2253023 A1 FR 2253023A1 FR 7439017 A FR7439017 A FR 7439017A FR 7439017 A FR7439017 A FR 7439017A FR 2253023 A1 FR2253023 A1 FR 2253023A1
- Authority
- FR
- France
- Prior art keywords
- converted
- iminohalide
- ceph
- reacted
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Novel 7-amino-ceph-3-em-4-carboxylic esters of the formula I and salts thereof in which R1 represents an optionally substituted 5- or 6-membered heterocyclic ring which can also be linked to a fused ring system; and R2 represents optionally substituted straight-chain or branched alkyl, cycloalkyl, aryl or a heterocyclic radical, are prepared. Suitable 7-acylamino ceph-3-em-4-carboxylic esters are reacted with a silylating agent in an inert solvent in the presence of a base and the product is converted with phosphorus pentachloride to give a complex-like compound. The amide group, which is activated by the silylation, is converted into the iminohalide by adding a halogenating agent, the iminohalide is reacted with an alcohol to give the imino ether hydrohalide, which is hydrolysed, and, if appropriate, the products of the process are subsequently converted into their salts.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2359402A DE2359402A1 (en) | 1973-11-29 | 1973-11-29 | 7-AMINO-DELTA 3-CEPHEM-4-CARBONIC ACID ESTER AND THE PROCESS FOR THEIR PRODUCTION |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2253023A1 true FR2253023A1 (en) | 1975-06-27 |
| FR2253023B1 FR2253023B1 (en) | 1979-10-12 |
Family
ID=5899369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7439017A Expired FR2253023B1 (en) | 1973-11-29 | 1974-11-28 |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS5088089A (en) |
| AT (1) | AT333430B (en) |
| BE (1) | BE822782A (en) |
| CA (1) | CA1074299A (en) |
| CH (1) | CH615187A5 (en) |
| DE (1) | DE2359402A1 (en) |
| DK (1) | DK616874A (en) |
| FI (1) | FI343674A (en) |
| FR (1) | FR2253023B1 (en) |
| IL (1) | IL46120A0 (en) |
| IT (1) | IT1051436B (en) |
| LU (1) | LU71380A1 (en) |
| NL (1) | NL7415274A (en) |
| NO (1) | NO744297L (en) |
| SE (1) | SE7414995L (en) |
-
1973
- 1973-11-29 DE DE2359402A patent/DE2359402A1/en not_active Withdrawn
-
1974
- 1974-10-22 CA CA212,038A patent/CA1074299A/en not_active Expired
- 1974-11-22 NL NL7415274A patent/NL7415274A/en not_active Application Discontinuation
- 1974-11-25 IL IL46120A patent/IL46120A0/en unknown
- 1974-11-26 CH CH1569274A patent/CH615187A5/en not_active IP Right Cessation
- 1974-11-27 DK DK616874A patent/DK616874A/da unknown
- 1974-11-27 IT IT29921/74A patent/IT1051436B/en active
- 1974-11-27 LU LU71380A patent/LU71380A1/xx unknown
- 1974-11-27 FI FI3436/74A patent/FI343674A/fi unknown
- 1974-11-28 FR FR7439017A patent/FR2253023B1/fr not_active Expired
- 1974-11-28 AT AT953374A patent/AT333430B/en not_active IP Right Cessation
- 1974-11-28 NO NO744297A patent/NO744297L/no unknown
- 1974-11-29 SE SE7414995A patent/SE7414995L/xx unknown
- 1974-11-29 BE BE151012A patent/BE822782A/en unknown
- 1974-11-29 JP JP49136374A patent/JPS5088089A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5088089A (en) | 1975-07-15 |
| LU71380A1 (en) | 1976-09-06 |
| DE2359402A1 (en) | 1975-06-05 |
| FI343674A (en) | 1975-05-30 |
| CH615187A5 (en) | 1980-01-15 |
| ATA953374A (en) | 1976-03-15 |
| AT333430B (en) | 1976-11-25 |
| NL7415274A (en) | 1975-06-02 |
| IL46120A0 (en) | 1975-02-10 |
| NO744297L (en) | 1975-06-23 |
| DK616874A (en) | 1975-07-28 |
| BE822782A (en) | 1975-05-29 |
| IT1051436B (en) | 1981-04-21 |
| SE7414995L (en) | 1975-05-30 |
| CA1074299A (en) | 1980-03-25 |
| FR2253023B1 (en) | 1979-10-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |