FR2244454A1 - - Google Patents

Info

Publication number
FR2244454A1
FR2244454A1 FR7432098A FR7432098A FR2244454A1 FR 2244454 A1 FR2244454 A1 FR 2244454A1 FR 7432098 A FR7432098 A FR 7432098A FR 7432098 A FR7432098 A FR 7432098A FR 2244454 A1 FR2244454 A1 FR 2244454A1
Authority
FR
France
Prior art keywords
catecholamine
acid
addition
compound
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7432098A
Other languages
French (fr)
Other versions
FR2244454B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith and Nephew Pharmaceuticals Ltd
Original Assignee
Smith and Nephew Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB44660/73A external-priority patent/GB1479597A/en
Application filed by Smith and Nephew Pharmaceuticals Ltd filed Critical Smith and Nephew Pharmaceuticals Ltd
Publication of FR2244454A1 publication Critical patent/FR2244454A1/fr
Application granted granted Critical
Publication of FR2244454B1 publication Critical patent/FR2244454B1/fr
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Ophthalmology & Optometry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Mixing of an aqueous suspension of a catecholamine in the presence of disodium edetate and sodium metabisulphite with active charcoal at a pH of 4.5 under nitrogen and filtration results in a catecholamine solution with less than 1 ppm heavy metals, from which the catecholamine is precipitated and converted into a water-soluble complex with a thiol derivative of an alpha -amino acid by addition of a 0.5 - 5 % by weight aqueous solution of the thiolic compound together with an acid or a compound with an acid reaction, and subsequent addition of a base to a pH of 6.0 - 7.5. The prepared solutions are, owing to the absence of ferric ions and borate ions, stable even under aerobic conditions and are used as eye drops for the treatment of glaucoma.
FR7432098A 1973-09-24 1974-09-24 Expired FR2244454B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB4466173 1973-09-24
GB44660/73A GB1479597A (en) 1973-09-24 1973-09-24 Stabilized aqueous catecholamine solutions

Publications (2)

Publication Number Publication Date
FR2244454A1 true FR2244454A1 (en) 1975-04-18
FR2244454B1 FR2244454B1 (en) 1978-09-22

Family

ID=26265432

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7432098A Expired FR2244454B1 (en) 1973-09-24 1974-09-24

Country Status (9)

Country Link
CA (1) CA1027043A (en)
CH (1) CH618604A5 (en)
DE (1) DE2445270C2 (en)
DK (1) DK139658B (en)
FR (1) FR2244454B1 (en)
HU (2) HU171831B (en)
NL (1) NL7412570A (en)
NO (1) NO142241C (en)
SE (1) SE429494B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0858803A1 (en) * 1995-08-28 1998-08-19 Showa Yakuhin Kako Co. Ltd Composition for local anesthesia

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2070173A1 (en) * 1969-10-29 1971-09-10 Alcon Lab In Stabilized aqs pyrocatecholamine prepns

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0858803A1 (en) * 1995-08-28 1998-08-19 Showa Yakuhin Kako Co. Ltd Composition for local anesthesia
EP0858803A4 (en) * 1995-08-28 2000-02-09 Showa Pharm Chem Ind Composition for local anesthesia

Also Published As

Publication number Publication date
SE7411915L (en) 1975-03-25
DE2445270A1 (en) 1975-04-03
HU171831B (en) 1978-03-28
HU173655B (en) 1979-07-28
NO743385L (en) 1975-04-21
CH618604A5 (en) 1980-08-15
CA1027043A (en) 1978-02-28
NO142241B (en) 1980-04-14
DK139658C (en) 1979-09-24
AU7362574A (en) 1976-04-01
DE2445270C2 (en) 1986-03-06
NL7412570A (en) 1975-03-26
NO142241C (en) 1980-07-30
FR2244454B1 (en) 1978-09-22
DK139658B (en) 1979-03-26
DK498274A (en) 1975-05-26
SE429494B (en) 1983-09-12

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Legal Events

Date Code Title Description
ST Notification of lapse