GB1479597A - Stabilized aqueous catecholamine solutions - Google Patents

Stabilized aqueous catecholamine solutions

Info

Publication number
GB1479597A
GB1479597A GB44660/73A GB4466073A GB1479597A GB 1479597 A GB1479597 A GB 1479597A GB 44660/73 A GB44660/73 A GB 44660/73A GB 4466073 A GB4466073 A GB 4466073A GB 1479597 A GB1479597 A GB 1479597A
Authority
GB
United Kingdom
Prior art keywords
acid
catecholamine
compound
thiolic
solutions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB44660/73A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith and Nephew Pharmaceuticals Ltd
Original Assignee
Smith and Nephew Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith and Nephew Pharmaceuticals Ltd filed Critical Smith and Nephew Pharmaceuticals Ltd
Priority to GB44660/73A priority Critical patent/GB1479597A/en
Priority to NO743385A priority patent/NO142241C/en
Priority to ZA00745993A priority patent/ZA745993B/en
Priority to DE2445270A priority patent/DE2445270C2/en
Priority to DK498274AA priority patent/DK139658B/en
Priority to SE7411915A priority patent/SE429494B/en
Priority to CA209,766A priority patent/CA1027043A/en
Priority to CH1288674A priority patent/CH618604A5/en
Priority to BE148853A priority patent/BE820293A/en
Priority to AU73625/74A priority patent/AU484587B2/en
Priority to NL7412570A priority patent/NL7412570A/en
Priority to HU74SI00001431A priority patent/HU171831B/en
Priority to HU74SI1586A priority patent/HU173655B/en
Priority to FR7432098A priority patent/FR2244454B1/fr
Priority to US05/744,045 priority patent/US4164570A/en
Publication of GB1479597A publication Critical patent/GB1479597A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1479597 Stabilised catecholamine solutions SMITH & NEPHEW PHARMACEUTICALS Ltd 24 Sept 1974 [24 Sept 1973 (2)] 44660/73 and 44661/73 Heading A5B A topical aqueous solution especially suitable for application to the eye for the treatment of open-angle glaucoma comprises 0.1 to 5% by weight of a therapeutically active catecholamine in purified form, from 0.5 to 5% by weight of a water-soluble pharmacologically tolerated thiolic stabilising agent, at least one acid or acid-reacting compound unless the thiolic compound is suitably acidic, whereby the catecholamine is solubilised, and a base to bring the pH to 6.0 to 7.5, the solution being free from borate ions. The catecholamine may be adrenaline, isoprenaline or noradrenaline. The thiolic compound may be cysteine, N- acetyl cysteine, α-mercaptol acetic acid, α- mercaptolpropionic acid, methyl cysteinate, 1- thiosorbitol, or 1-thioglycerol. The base may be ammonium hydroxide; the acid or acidic compound may be citric acid, a phosphate or phosphoric acid. The solutions may also contain an adrenergic blocking agent such as guanethidine or a salt thereof.
GB44660/73A 1973-09-24 1973-09-24 Stabilized aqueous catecholamine solutions Expired GB1479597A (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
GB44660/73A GB1479597A (en) 1973-09-24 1973-09-24 Stabilized aqueous catecholamine solutions
NO743385A NO142241C (en) 1973-09-24 1974-09-20 PROCEDURE FOR PREPARING A STABLE, Aqueous SOLUTION FOR TOPICAL USE OF LIVING TISSUE
ZA00745993A ZA745993B (en) 1973-09-24 1974-09-20 Stabilized aqueous catecholamine solutions
DE2445270A DE2445270C2 (en) 1973-09-24 1974-09-21 Stabilized aqueous adrenaline eye solution
DK498274AA DK139658B (en) 1973-09-24 1974-09-23 Process for the preparation of an aqueous solution of adrenaline for topical application.
SE7411915A SE429494B (en) 1973-09-24 1974-09-23 SET TO MAKE A BORATE-FREE WATER SOLUTION FOR TOPICAL USE IN TREATMENT OF LATE-ANGLE GLAUCUM
CA209,766A CA1027043A (en) 1973-09-24 1974-09-23 Stabilized aqueous catecholamine solutions
CH1288674A CH618604A5 (en) 1973-09-24 1974-09-24 Process for the preparation of stabilised liquid solutions of catecholamines.
BE148853A BE820293A (en) 1973-09-24 1974-09-24 PROCESS FOR PREPARING STABILIZED AQUEOUS SOLUTIONS OF CATECHOLAMINES
AU73625/74A AU484587B2 (en) 1973-09-24 1974-09-24 Stabilized aqueous catecholamine solutions
NL7412570A NL7412570A (en) 1973-09-24 1974-09-24 PROCEDURE FOR PREPARING Aqueous SOLUTIONS CONTAINING A CATECHOLAMINE.
HU74SI00001431A HU171831B (en) 1973-09-24 1974-09-24 Process for preparing a stabilized aequous solution of alpha-/3,4-dihydroxyphenyl/-beta-methyl-amino-etanol suitable for local application on a living tissue
HU74SI1586A HU173655B (en) 1973-09-24 1974-09-24 Process for producing pharmaceutical compositions containing alpha-bracket-3,4-dihydroxyphenyl-bracket closed-beta-methyl-amino-ethanol and and an agent of adrenerg neuron-bloccing activity
FR7432098A FR2244454B1 (en) 1973-09-24 1974-09-24
US05/744,045 US4164570A (en) 1973-09-24 1976-11-22 Stabilized aqueous catecholamine solutions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB44660/73A GB1479597A (en) 1973-09-24 1973-09-24 Stabilized aqueous catecholamine solutions

Publications (1)

Publication Number Publication Date
GB1479597A true GB1479597A (en) 1977-07-13

Family

ID=10434245

Family Applications (1)

Application Number Title Priority Date Filing Date
GB44660/73A Expired GB1479597A (en) 1973-09-24 1973-09-24 Stabilized aqueous catecholamine solutions

Country Status (3)

Country Link
BE (1) BE820293A (en)
GB (1) GB1479597A (en)
ZA (1) ZA745993B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011000758A1 (en) * 2009-06-30 2011-01-06 Basf Se Aqueous alkaline cleaning compositions and methods of their use
US11413259B2 (en) 2017-01-30 2022-08-16 Nevakar Injectables Inc. Norepinephrine compositions and methods therefor

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011000758A1 (en) * 2009-06-30 2011-01-06 Basf Se Aqueous alkaline cleaning compositions and methods of their use
US8969275B2 (en) 2009-06-30 2015-03-03 Basf Se Aqueous alkaline cleaning compositions and methods of their use
US11413259B2 (en) 2017-01-30 2022-08-16 Nevakar Injectables Inc. Norepinephrine compositions and methods therefor
US11602508B2 (en) 2017-01-30 2023-03-14 Nevakar Injectables Inc. Norepinephrine compositions and methods therefor

Also Published As

Publication number Publication date
ZA745993B (en) 1975-09-24
BE820293A (en) 1975-03-24

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Legal Events

Date Code Title Description
PS Patent sealed
PE20 Patent expired after termination of 20 years

Effective date: 19940923