FR2235702A1 - Chymopapain from Carica papaya juice - with antiinflammatory activity for local and systemic use, e.g. in treating haematomas - Google Patents

Chymopapain from Carica papaya juice - with antiinflammatory activity for local and systemic use, e.g. in treating haematomas

Info

Publication number
FR2235702A1
FR2235702A1 FR7322964A FR7322964A FR2235702A1 FR 2235702 A1 FR2235702 A1 FR 2235702A1 FR 7322964 A FR7322964 A FR 7322964A FR 7322964 A FR7322964 A FR 7322964A FR 2235702 A1 FR2235702 A1 FR 2235702A1
Authority
FR
France
Prior art keywords
chymopapain
treating
carica papaya
haematomas
local
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7322964A
Other languages
French (fr)
Other versions
FR2235702B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cooperation Pharmaceutique Francaise SAS
Original Assignee
Cooperation Pharmaceutique Francaise SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cooperation Pharmaceutique Francaise SAS filed Critical Cooperation Pharmaceutique Francaise SAS
Priority to FR7322964A priority Critical patent/FR2235702A1/en
Publication of FR2235702A1 publication Critical patent/FR2235702A1/en
Application granted granted Critical
Publication of FR2235702B1 publication Critical patent/FR2235702B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/63—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Botany (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Therapeutic compsns. contg. as active component chymopapain, are useful as antiinflammatory agent for systemic or topical administration. Also used in normal proteolytic procedures. The chymopapain is obtd. by treating juice from Carica papaya with a weak cation-exchange resin adjusted to the isoelectric point of papain, 8. 4, washing out papain and then elution of the chymopapain with a soln. of NaC1 contg. about 0.5% of Na2S2O3. Eluate is dialysed, opt. after ultrafiltration spray- or freeze-drying and redissolving in a small volume of solvent, finally freeze-drying the dialysate after concn.
FR7322964A 1973-06-22 1973-06-22 Chymopapain from Carica papaya juice - with antiinflammatory activity for local and systemic use, e.g. in treating haematomas Granted FR2235702A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7322964A FR2235702A1 (en) 1973-06-22 1973-06-22 Chymopapain from Carica papaya juice - with antiinflammatory activity for local and systemic use, e.g. in treating haematomas

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7322964A FR2235702A1 (en) 1973-06-22 1973-06-22 Chymopapain from Carica papaya juice - with antiinflammatory activity for local and systemic use, e.g. in treating haematomas

Publications (2)

Publication Number Publication Date
FR2235702A1 true FR2235702A1 (en) 1975-01-31
FR2235702B1 FR2235702B1 (en) 1976-12-31

Family

ID=9121440

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7322964A Granted FR2235702A1 (en) 1973-06-22 1973-06-22 Chymopapain from Carica papaya juice - with antiinflammatory activity for local and systemic use, e.g. in treating haematomas

Country Status (1)

Country Link
FR (1) FR2235702A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4439423A (en) * 1981-05-13 1984-03-27 Smith Laboratories, Inc. Chymopapain and method for its use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1262562A (en) * 1956-02-21 1961-06-05 Nagase & Co Protease purification process
US3320131A (en) * 1964-10-23 1967-05-16 Baxter Laboratories Inc Method for the treatment of herniation of intervertebral discs
FR1592192A (en) * 1967-11-07 1970-05-11

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1262562A (en) * 1956-02-21 1961-06-05 Nagase & Co Protease purification process
US3320131A (en) * 1964-10-23 1967-05-16 Baxter Laboratories Inc Method for the treatment of herniation of intervertebral discs
FR1592192A (en) * 1967-11-07 1970-05-11

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
UE CHEMICAL ABSTRACTS VOL.67 1967 61110 R CITE BIOCHIM.) *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4439423A (en) * 1981-05-13 1984-03-27 Smith Laboratories, Inc. Chymopapain and method for its use

Also Published As

Publication number Publication date
FR2235702B1 (en) 1976-12-31

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Legal Events

Date Code Title Description
ST Notification of lapse